Bronchial eosinophils, neutrophils, and CD8 + T cells influence asthma control and lung function in schoolchildren and adolescents with severe treatment-resistant asthma

Bronchial eosinophils, neutrophils, and CD8 + T cells influence asthma control and lung function in schoolchildren and adolescents with severe treatment-resistant asthma

Abstract Background Studies in adult severe treatment-resistant asthma (STRA) have demonstrated heterogeneous pathophysiology. Studies in the pediatric age group are still scarce, and few include bronchial tissue analysis. Objective We investigated 6–18-year-old patients diagnosed with STRA in Sao P...

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Main Authors: Miriam Cardoso Neves Eller, Karina Pierantozzi Vergani, Beatriz Mangueira Saraiva-Romanholo, Natália de Souza Xavier Costa, Jôse Mára de Brito, Leila Antonangelo, Caroline Silvério Faria, Joaquim Carlos Rodrigues, Thais Mauad
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Respiratory Research
Subjects:
Severe asthma
Children
Inflammatory cells profile
Sputum
Endobronchial biopsy
CD8 + T cell
Online Access:https://doi.org/10.1186/s12931-022-02259-4

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