Spread of Multidrug-Resistant Rhodococcus equi, United States
Multidrug resistance has been detected in the animal and zoonotic human pathogen Rhodococcus equi after mass macrolide/rifampin antibioprophylaxis in endemically affected equine farms in the United States. Multidrug-resistant (MDR) R. equi emerged upon acquisition of pRERm46, a conjugative plasmid c...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2021-02-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/27/2/20-3030_article |
| _version_ | 1819241782210199552 |
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| author | Sonsiray Álvarez-Narváez Steeve Giguère Noah Cohen Nathan Slovis José A. Vázquez-Boland |
| author_facet | Sonsiray Álvarez-Narváez Steeve Giguère Noah Cohen Nathan Slovis José A. Vázquez-Boland |
| author_sort | Sonsiray Álvarez-Narváez |
| collection | DOAJ |
| description | Multidrug resistance has been detected in the animal and zoonotic human pathogen Rhodococcus equi after mass macrolide/rifampin antibioprophylaxis in endemically affected equine farms in the United States. Multidrug-resistant (MDR) R. equi emerged upon acquisition of pRERm46, a conjugative plasmid conferring resistance to macrolides, lincosamides, streptogramins, and, as we describe, tetracycline. Phylogenomic analyses indicate that the increasing prevalence of MDR R. equi since it was first documented in 2002 is caused by a clone, R. equi 2287, attributable to coselection of pRErm46 with a chromosomal rpoBS531F mutation driven by macrolide/rifampin therapy. pRErm46 spillover to other R. equi genotypes has given rise to a novel MDR clone, G2016, associated with a distinct rpoBS531Y mutation. Our findings illustrate that overuse of antimicrobial prophylaxis in animals can generate MDR pathogens with zoonotic potential. MDR R. equi and pRErm46-mediated resistance are currently disseminating in the United States and are likely to spread internationally through horse movements. |
| first_indexed | 2024-12-23T14:29:23Z |
| format | Article |
| id | doaj.art-89936599b9ae414b8f87e242e57ed3a7 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-23T14:29:23Z |
| publishDate | 2021-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-89936599b9ae414b8f87e242e57ed3a72022-12-21T17:43:33ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592021-02-0127252953710.3201/eid2702.203030Spread of Multidrug-Resistant Rhodococcus equi, United StatesSonsiray Álvarez-NarváezSteeve GiguèreNoah CohenNathan SlovisJosé A. Vázquez-BolandMultidrug resistance has been detected in the animal and zoonotic human pathogen Rhodococcus equi after mass macrolide/rifampin antibioprophylaxis in endemically affected equine farms in the United States. Multidrug-resistant (MDR) R. equi emerged upon acquisition of pRERm46, a conjugative plasmid conferring resistance to macrolides, lincosamides, streptogramins, and, as we describe, tetracycline. Phylogenomic analyses indicate that the increasing prevalence of MDR R. equi since it was first documented in 2002 is caused by a clone, R. equi 2287, attributable to coselection of pRErm46 with a chromosomal rpoBS531F mutation driven by macrolide/rifampin therapy. pRErm46 spillover to other R. equi genotypes has given rise to a novel MDR clone, G2016, associated with a distinct rpoBS531Y mutation. Our findings illustrate that overuse of antimicrobial prophylaxis in animals can generate MDR pathogens with zoonotic potential. MDR R. equi and pRErm46-mediated resistance are currently disseminating in the United States and are likely to spread internationally through horse movements.https://wwwnc.cdc.gov/eid/article/27/2/20-3030_articlemultidrug-resistant Rhodococcus equibacteriaMDR R. equierm(46)pRErm46TnRErm46 |
| spellingShingle | Sonsiray Álvarez-Narváez Steeve Giguère Noah Cohen Nathan Slovis José A. Vázquez-Boland Spread of Multidrug-Resistant Rhodococcus equi, United States Emerging Infectious Diseases multidrug-resistant Rhodococcus equi bacteria MDR R. equi erm(46) pRErm46 TnRErm46 |
| title | Spread of Multidrug-Resistant Rhodococcus equi, United States |
| title_full | Spread of Multidrug-Resistant Rhodococcus equi, United States |
| title_fullStr | Spread of Multidrug-Resistant Rhodococcus equi, United States |
| title_full_unstemmed | Spread of Multidrug-Resistant Rhodococcus equi, United States |
| title_short | Spread of Multidrug-Resistant Rhodococcus equi, United States |
| title_sort | spread of multidrug resistant rhodococcus equi united states |
| topic | multidrug-resistant Rhodococcus equi bacteria MDR R. equi erm(46) pRErm46 TnRErm46 |
| url | https://wwwnc.cdc.gov/eid/article/27/2/20-3030_article |
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