Bacteremia in Pediatric Oncology Patients; A Single-Center Experience
Objective: To study organisms causing bacteremia and their outcome in cancer children with febrile neutropenia (FN) admitted at our centre. Study Design: Retrospective longitudinal study. Place and duration of study: Department of Pediatric Oncology, Shaukat Khanum Memorial Cancer Hospital,...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Army Medical College Rawalpindi
2022-10-01
|
| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/3993 |
| _version_ | 1828179018481926144 |
|---|---|
| author | Zunaira Shaukat Rabia Wali Saadiya Javed Khan Summiya Nizamuddin Romena Qazi Kainat Memon Najma Shaheen |
| author_facet | Zunaira Shaukat Rabia Wali Saadiya Javed Khan Summiya Nizamuddin Romena Qazi Kainat Memon Najma Shaheen |
| author_sort | Zunaira Shaukat |
| collection | DOAJ |
| description |
Objective: To study organisms causing bacteremia and their outcome in cancer children with febrile neutropenia (FN) admitted at our centre.
Study Design: Retrospective longitudinal study.
Place and duration of study: Department of Pediatric Oncology, Shaukat Khanum Memorial Cancer Hospital, Lahore, from Feb to Dec 2017.
Methodology: All pediatric oncology patients with febrile neutropenia admitted to the inpatient department were included. Data fields included age, diagnoses, demographics, organism types, time to positivity, multi-drug resistance, antibiotics, and outcome.
Results: A total of 391 episodes of febrile neutropenia were documented among 86 patients. The mean age was 4.7±2.7 years. Twelve (14.0%) patients had intensive care admission, and 9(10.5%) of them died. Fifty-four (63.0%) children had primary diagnoses of haematological malignancies. Sixty-five percent had mucositis, central catheter, or both as risk factors. Thirty-nine isolates were cultured in 391 febrile-neutropenic episodes. Escherichia coli was the most frequently isolated organism in 16(41.0%) cultures, followed by Pseudomonas and Streptococcus pneumoniae in 4(10.3%) each. Poly-microbial isolates were seen in 6(15.4%) cultures. Multi-drug resistance was found in 12(30.8%) isolates. Thirty-four (87.0%) patients with positive cultures received appropriate antibiotics. Majority organisms were sensitive to Piperacillin/Tazobactam (14,35.9%) followed by Meropenem (10, 25.6%) and Colistin (6, 15.4%).
Conclusions: Rapid identification of organisms from positive blood cultures combined with antimicrobial stewardship can have improved antibiotic treatment and outcomes.
|
| first_indexed | 2024-04-12T05:24:47Z |
| format | Article |
| id | doaj.art-8993e5e11340459b850861a2a7a18312 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-04-12T05:24:47Z |
| publishDate | 2022-10-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-8993e5e11340459b850861a2a7a183122022-12-22T03:46:20ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422022-10-0172510.51253/pafmj.v72i5.3993Bacteremia in Pediatric Oncology Patients; A Single-Center ExperienceZunaira Shaukat0Rabia Wali1Saadiya Javed Khan2Summiya Nizamuddin3Romena Qazi4Kainat Memon5Najma Shaheen6Shaukat Khanum Memorial Cancer, Hospital Lahore, PakistanShaukat Khanum Memorial Cancer, Hospital Lahore, PakistanShaukat Khanum Memorial Cancer, Hospital Lahore, PakistanShaukat Khanum Memorial Cancer, Hospital Lahore, PakistanShaukat Khanum Memorial Cancer, Hospital Lahore, PakistanShaukat Khanum Memorial Cancer, Hospital Lahore, PakistanShaukat Khanum Memorial Cancer, Hospital Lahore, Pakistan Objective: To study organisms causing bacteremia and their outcome in cancer children with febrile neutropenia (FN) admitted at our centre. Study Design: Retrospective longitudinal study. Place and duration of study: Department of Pediatric Oncology, Shaukat Khanum Memorial Cancer Hospital, Lahore, from Feb to Dec 2017. Methodology: All pediatric oncology patients with febrile neutropenia admitted to the inpatient department were included. Data fields included age, diagnoses, demographics, organism types, time to positivity, multi-drug resistance, antibiotics, and outcome. Results: A total of 391 episodes of febrile neutropenia were documented among 86 patients. The mean age was 4.7±2.7 years. Twelve (14.0%) patients had intensive care admission, and 9(10.5%) of them died. Fifty-four (63.0%) children had primary diagnoses of haematological malignancies. Sixty-five percent had mucositis, central catheter, or both as risk factors. Thirty-nine isolates were cultured in 391 febrile-neutropenic episodes. Escherichia coli was the most frequently isolated organism in 16(41.0%) cultures, followed by Pseudomonas and Streptococcus pneumoniae in 4(10.3%) each. Poly-microbial isolates were seen in 6(15.4%) cultures. Multi-drug resistance was found in 12(30.8%) isolates. Thirty-four (87.0%) patients with positive cultures received appropriate antibiotics. Majority organisms were sensitive to Piperacillin/Tazobactam (14,35.9%) followed by Meropenem (10, 25.6%) and Colistin (6, 15.4%). Conclusions: Rapid identification of organisms from positive blood cultures combined with antimicrobial stewardship can have improved antibiotic treatment and outcomes. https://www.pafmj.org/index.php/PAFMJ/article/view/3993Antimicrobial StewardshipBacteremiaEscherichia coliFebrile neutropeniaMucositis |
| spellingShingle | Zunaira Shaukat Rabia Wali Saadiya Javed Khan Summiya Nizamuddin Romena Qazi Kainat Memon Najma Shaheen Bacteremia in Pediatric Oncology Patients; A Single-Center Experience Pakistan Armed Forces Medical Journal Antimicrobial Stewardship Bacteremia Escherichia coli Febrile neutropenia Mucositis |
| title | Bacteremia in Pediatric Oncology Patients; A Single-Center Experience |
| title_full | Bacteremia in Pediatric Oncology Patients; A Single-Center Experience |
| title_fullStr | Bacteremia in Pediatric Oncology Patients; A Single-Center Experience |
| title_full_unstemmed | Bacteremia in Pediatric Oncology Patients; A Single-Center Experience |
| title_short | Bacteremia in Pediatric Oncology Patients; A Single-Center Experience |
| title_sort | bacteremia in pediatric oncology patients a single center experience |
| topic | Antimicrobial Stewardship Bacteremia Escherichia coli Febrile neutropenia Mucositis |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/3993 |
| work_keys_str_mv | AT zunairashaukat bacteremiainpediatriconcologypatientsasinglecenterexperience AT rabiawali bacteremiainpediatriconcologypatientsasinglecenterexperience AT saadiyajavedkhan bacteremiainpediatriconcologypatientsasinglecenterexperience AT summiyanizamuddin bacteremiainpediatriconcologypatientsasinglecenterexperience AT romenaqazi bacteremiainpediatriconcologypatientsasinglecenterexperience AT kainatmemon bacteremiainpediatriconcologypatientsasinglecenterexperience AT najmashaheen bacteremiainpediatriconcologypatientsasinglecenterexperience |