Clinical Implications of Monogenic Versus Polygenic Hypercholesterolemia: Long‐Term Response to Treatment, Coronary Atherosclerosis Burden, and Cardiovascular Events

Clinical Implications of Monogenic Versus Polygenic Hypercholesterolemia: Long‐Term Response to Treatment, Coronary Atherosclerosis Burden, and Cardiovascular Events

Background Familial hypercholesterolemia (FH) may arise from deleterious monogenic variants in FH‐causing genes as well as from a polygenic cause. We evaluated the relationships between monogenic FH and polygenic hypercholesterolemia in influencing the long‐term response to therapy and the risk of a...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Laura D’Erasmo, Ilenia Minicocci, Alessia Di Costanzo, Giovanni Pigna, Daniela Commodari, Fabrizio Ceci, Anna Montali, Francesca Brancato, Ilaria Stanca, Antonio Nicolucci, Andrea Ascione, Nicola Galea, Iacopo Carbone, Marco Francone, Marianna Maranghi, Marcello Arca
Format:	Article
Sprog:	English
Udgivet:	Wiley 2021-05-01
Serier:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Fag:	atherosclerosis cardiovascular disease genetics hypercholesterolemia therapy
Online adgang:	https://www.ahajournals.org/doi/10.1161/JAHA.120.018932

Lignende værker

Higher Responsiveness to Rosuvastatin in Polygenic versus Monogenic Hypercholesterolemia: A Propensity Score Analysis
af: Agnieszka Mickiewicz, et al.
Udgivet: (2020-05-01)

Family and polygenic hypercholesterolemia: similarities and differencies by long-term follow-up
af: B M Lipovetskiy, et al.
Udgivet: (2009-03-01)

A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin
af: Luis G. Leal, et al.
Udgivet: (2020-06-01)

Polygenic risk score for hypercholesterolemia in a Brazilian familial hypercholesterolemia cohort
af: Isabella Ramos Lima, et al.
Udgivet: (2022-08-01)

Efficacy of Evolocumab in Monogenic vs Polygenic Hypercholesterolemia
af: Timothy Lee, BSc, et al.
Udgivet: (2019-05-01)

Genetics of Hypercholesterolemia: Comparison Between Familial Hypercholesterolemia and Hypercholesterolemia Nonrelated to LDL Receptor
af: Estíbaliz Jarauta, et al.
Udgivet: (2020-12-01)

Real‐World Effectiveness of PCSK9 Inhibitors in Reducing LDL‐C in Patients With Familial Hypercholesterolemia in Italy: A Retrospective Cohort Study Based on the AIFA Monitoring Registries
af: Marcello Arca, et al.
Udgivet: (2023-11-01)

Clinical Significance of Screening for Familial Hypercholesterolemia in Patients with Hypercholesterolemia
af: LI Yuan, MA Hongyang, LI Biao, YUE Anna, SHAO Yaqing, SUN Kangyun
Udgivet: (2024-12-01)

LIPOPROTEIN (a) LEVELS IN MONOGENIC VERSUS POLYGENIC HYPERCHOLESTEROLEMIA
af: A. Jain, et al.
Udgivet: (2021-09-01)

Twelve Variants Polygenic Score for Low‐Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations
af: Elena Olmastroni, et al.
Udgivet: (2022-04-01)

New Treatments on the Horizon for Familial Hypercholesterolemia
af: Khalid Al-Rasadi, et al.
Udgivet: (2017-11-01)

Familial Hypercholesterolemia in Cardiac Rehabilitation: a new field of interest
af: Marco Ambrosetti, et al.
Udgivet: (2015-08-01)

The panorama of familial hypercholesterolemia in Latin America: a systematic review[S]
af: Roopa Mehta, et al.
Udgivet: (2016-12-01)

The burden of severe hypercholesterolemia and familial hypercholesterolemia in a population-based setting in the US
af: Seyedmohammad Saadatagah, et al.
Udgivet: (2022-12-01)

Genetic Determinants of Plasma Low-Density Lipoprotein Cholesterol Levels: Monogenicity, Polygenicity, and “Missing” Heritability
af: Jesús Maria Martín-Campos
Udgivet: (2021-11-01)

SITOSTEROLEMIA – RARE CAUSE OF HYPERCHOLESTEROLEMIA IN CHILD
af: Antoneta Dacia Petroaie
Udgivet: (2019-02-01)

Familial homozygous hypercholesterolemia with arcus cornea and xanthomas: A rare but serious entity
af: Amal Chamli, et al.
Udgivet: (2023-03-01)

Role of lipoprotein apheresis in the management of familial hypercholesterolemia
af: Shamanna Seshadri Iyengar, et al.
Udgivet: (2021-01-01)

School-based universal screening for hypercholesterolemia in children
af: Chang-Hsien Yu, et al.
Udgivet: (2022-07-01)

The prevalence of familial hypercholesterolemia in teenagers from Timișoara
af: Andreea Dumitrescu¹,²,, et al.
Udgivet: (2016-12-01)

Effects of <i>Lippia citriodora</i> Leaf Extract on Lipid and Oxidative Blood Profile of Volunteers with Hypercholesterolemia: A Preliminary Study
af: Antonella Angiolillo, et al.
Udgivet: (2021-03-01)

Familial hypercholesterolemia revealed by multiple xanthomas
af: Nassiba Elouarradi, et al.
Udgivet: (2018-05-01)

A case of familial hypercholesterolemia
af: Augusto Zaninelli
Udgivet: (2008-06-01)

Monacolin K in the treatment of hypercholesterolemia - chance or threat?
af: Katarzyna Krotowska
Udgivet: (2024-12-01)

Immune Modulatory Effects of Hypercholesterolemia: Can Atorvastatin Convert the Detrimental Effect of Hypercholesterolemia on the Immune System?
af: Zeinab Emruzi, et al.
Udgivet: (2019-10-01)

Hypertension and Hypercholesterolemia: is it Time for Anti-«Lipitensive» Therapy?
af: Z. D. Kobalava, et al.
Udgivet: (2020-11-01)

Relationship between hypercholesterolemia and osteoarthritis (preliminary results)
af: Elena A. Taskina, et al.
Udgivet: (2024-06-01)

Early Atherosclerosis in Children in Familial Hypercholesterolemia : A 2 Case Report
af: Narumon Densupsoontorn, et al.
Udgivet: (2020-08-01)

Benefit–risk assessment of pitavastatin for the treatment of hypercholesterolemia in older patients
af: Chamberlin KW, et al.
Udgivet: (2015-04-01)

Lipoprotein(a) Genotype Influences the Clinical Diagnosis of Familial Hypercholesterolemia
af: Elena Olmastroni, et al.
Udgivet: (2023-05-01)

Safety and Effectiveness of Low‐Density Lipoprotein Cholesterol–Lowering Therapy With Evolocumab for Familial Hypercholesterolemia/Hypercholesterolemia in Japan: A Real‐World, Postmarketing, Single‐Arm Study
af: Koutaro Yokote, et al.
Udgivet: (2024-11-01)

Amaranthus viridis L. as alternative treatment for hypercholesterolemia and atherosclerosis
af: Salvamani, Shamala
Udgivet: (2016)

Clinical case of myocardial infarction with unspecified familial hypercholesterolemia
af: Natalya G. Lozhkina, et al.
Udgivet: (2022-01-01)

Doppler study of cerebral arteries in hypercholesterolemia
af: Ghabili K
Udgivet: (2011-03-01)

Genetic Testing for Familial Hypercholesterolemia in a Pediatric Group: A Romanian Showcase
af: Andreea Teodora Constantin, et al.
Udgivet: (2023-06-01)

Unraveling the genetic background of individuals with a clinical familial hypercholesterolemia phenotype
af: Ana Margarida Medeiros, et al.
Udgivet: (2024-02-01)

Familial hypercholesterolemia: The skin speaks
af: Johns T Johnson, et al.
Udgivet: (2020-01-01)

The Prevalence and Genetic Spectrum of Familial Hypercholesterolemia in Qatar Based on Whole Genome Sequencing of 14,000 Subjects
af: Ilhame Diboun, et al.
Udgivet: (2022-07-01)

Patient experiences align with the familial hypercholesterolemia global call to action
af: Laney K. Jones, et al.
Udgivet: (2022-06-01)

Scientific Disagreement and Evidential Pluralism: Lessons from the Studies on Hypercholesterolemia
af: Veli-Pekka Parkkinen, et al.
Udgivet: (2018-05-01)