Clinical Implications of Monogenic Versus Polygenic Hypercholesterolemia: Long‐Term Response to Treatment, Coronary Atherosclerosis Burden, and Cardiovascular Events

Clinical Implications of Monogenic Versus Polygenic Hypercholesterolemia: Long‐Term Response to Treatment, Coronary Atherosclerosis Burden, and Cardiovascular Events

Background Familial hypercholesterolemia (FH) may arise from deleterious monogenic variants in FH‐causing genes as well as from a polygenic cause. We evaluated the relationships between monogenic FH and polygenic hypercholesterolemia in influencing the long‐term response to therapy and the risk of a...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Laura D’Erasmo, Ilenia Minicocci, Alessia Di Costanzo, Giovanni Pigna, Daniela Commodari, Fabrizio Ceci, Anna Montali, Francesca Brancato, Ilaria Stanca, Antonio Nicolucci, Andrea Ascione, Nicola Galea, Iacopo Carbone, Marco Francone, Marianna Maranghi, Marcello Arca
Μορφή:	Άρθρο
Γλώσσα:	English
Έκδοση:	Wiley 2021-05-01
Σειρά:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Θέματα:	atherosclerosis cardiovascular disease genetics hypercholesterolemia therapy
Διαθέσιμο Online:	https://www.ahajournals.org/doi/10.1161/JAHA.120.018932

Παρόμοια τεκμήρια

Higher Responsiveness to Rosuvastatin in Polygenic versus Monogenic Hypercholesterolemia: A Propensity Score Analysis
ανά: Agnieszka Mickiewicz, κ.ά.
Έκδοση: (2020-05-01)

Family and polygenic hypercholesterolemia: similarities and differencies by long-term follow-up
ανά: B M Lipovetskiy, κ.ά.
Έκδοση: (2009-03-01)

A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin
ανά: Luis G. Leal, κ.ά.
Έκδοση: (2020-06-01)

Polygenic risk score for hypercholesterolemia in a Brazilian familial hypercholesterolemia cohort
ανά: Isabella Ramos Lima, κ.ά.
Έκδοση: (2022-08-01)

Efficacy of Evolocumab in Monogenic vs Polygenic Hypercholesterolemia
ανά: Timothy Lee, BSc, κ.ά.
Έκδοση: (2019-05-01)

Genetics of Hypercholesterolemia: Comparison Between Familial Hypercholesterolemia and Hypercholesterolemia Nonrelated to LDL Receptor
ανά: Estíbaliz Jarauta, κ.ά.
Έκδοση: (2020-12-01)

Real‐World Effectiveness of PCSK9 Inhibitors in Reducing LDL‐C in Patients With Familial Hypercholesterolemia in Italy: A Retrospective Cohort Study Based on the AIFA Monitoring Registries
ανά: Marcello Arca, κ.ά.
Έκδοση: (2023-11-01)

Clinical Significance of Screening for Familial Hypercholesterolemia in Patients with Hypercholesterolemia
ανά: LI Yuan, MA Hongyang, LI Biao, YUE Anna, SHAO Yaqing, SUN Kangyun
Έκδοση: (2024-12-01)

LIPOPROTEIN (a) LEVELS IN MONOGENIC VERSUS POLYGENIC HYPERCHOLESTEROLEMIA
ανά: A. Jain, κ.ά.
Έκδοση: (2021-09-01)

Twelve Variants Polygenic Score for Low‐Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations
ανά: Elena Olmastroni, κ.ά.
Έκδοση: (2022-04-01)

New Treatments on the Horizon for Familial Hypercholesterolemia
ανά: Khalid Al-Rasadi, κ.ά.
Έκδοση: (2017-11-01)

Familial Hypercholesterolemia in Cardiac Rehabilitation: a new field of interest
ανά: Marco Ambrosetti, κ.ά.
Έκδοση: (2015-08-01)

The panorama of familial hypercholesterolemia in Latin America: a systematic review[S]
ανά: Roopa Mehta, κ.ά.
Έκδοση: (2016-12-01)

The burden of severe hypercholesterolemia and familial hypercholesterolemia in a population-based setting in the US
ανά: Seyedmohammad Saadatagah, κ.ά.
Έκδοση: (2022-12-01)

Genetic Determinants of Plasma Low-Density Lipoprotein Cholesterol Levels: Monogenicity, Polygenicity, and “Missing” Heritability
ανά: Jesús Maria Martín-Campos
Έκδοση: (2021-11-01)

SITOSTEROLEMIA – RARE CAUSE OF HYPERCHOLESTEROLEMIA IN CHILD
ανά: Antoneta Dacia Petroaie
Έκδοση: (2019-02-01)

Familial homozygous hypercholesterolemia with arcus cornea and xanthomas: A rare but serious entity
ανά: Amal Chamli, κ.ά.
Έκδοση: (2023-03-01)

Role of lipoprotein apheresis in the management of familial hypercholesterolemia
ανά: Shamanna Seshadri Iyengar, κ.ά.
Έκδοση: (2021-01-01)

School-based universal screening for hypercholesterolemia in children
ανά: Chang-Hsien Yu, κ.ά.
Έκδοση: (2022-07-01)

The prevalence of familial hypercholesterolemia in teenagers from Timișoara
ανά: Andreea Dumitrescu¹,²,, κ.ά.
Έκδοση: (2016-12-01)

Effects of <i>Lippia citriodora</i> Leaf Extract on Lipid and Oxidative Blood Profile of Volunteers with Hypercholesterolemia: A Preliminary Study
ανά: Antonella Angiolillo, κ.ά.
Έκδοση: (2021-03-01)

Familial hypercholesterolemia revealed by multiple xanthomas
ανά: Nassiba Elouarradi, κ.ά.
Έκδοση: (2018-05-01)

A case of familial hypercholesterolemia
ανά: Augusto Zaninelli
Έκδοση: (2008-06-01)

Monacolin K in the treatment of hypercholesterolemia - chance or threat?
ανά: Katarzyna Krotowska
Έκδοση: (2024-12-01)

Immune Modulatory Effects of Hypercholesterolemia: Can Atorvastatin Convert the Detrimental Effect of Hypercholesterolemia on the Immune System?
ανά: Zeinab Emruzi, κ.ά.
Έκδοση: (2019-10-01)

Hypertension and Hypercholesterolemia: is it Time for Anti-«Lipitensive» Therapy?
ανά: Z. D. Kobalava, κ.ά.
Έκδοση: (2020-11-01)

Relationship between hypercholesterolemia and osteoarthritis (preliminary results)
ανά: Elena A. Taskina, κ.ά.
Έκδοση: (2024-06-01)

Early Atherosclerosis in Children in Familial Hypercholesterolemia : A 2 Case Report
ανά: Narumon Densupsoontorn, κ.ά.
Έκδοση: (2020-08-01)

Benefit–risk assessment of pitavastatin for the treatment of hypercholesterolemia in older patients
ανά: Chamberlin KW, κ.ά.
Έκδοση: (2015-04-01)

Lipoprotein(a) Genotype Influences the Clinical Diagnosis of Familial Hypercholesterolemia
ανά: Elena Olmastroni, κ.ά.
Έκδοση: (2023-05-01)

Safety and Effectiveness of Low‐Density Lipoprotein Cholesterol–Lowering Therapy With Evolocumab for Familial Hypercholesterolemia/Hypercholesterolemia in Japan: A Real‐World, Postmarketing, Single‐Arm Study
ανά: Koutaro Yokote, κ.ά.
Έκδοση: (2024-11-01)

Amaranthus viridis L. as alternative treatment for hypercholesterolemia and atherosclerosis
ανά: Salvamani, Shamala
Έκδοση: (2016)

Clinical case of myocardial infarction with unspecified familial hypercholesterolemia
ανά: Natalya G. Lozhkina, κ.ά.
Έκδοση: (2022-01-01)

Doppler study of cerebral arteries in hypercholesterolemia
ανά: Ghabili K
Έκδοση: (2011-03-01)

Genetic Testing for Familial Hypercholesterolemia in a Pediatric Group: A Romanian Showcase
ανά: Andreea Teodora Constantin, κ.ά.
Έκδοση: (2023-06-01)

Unraveling the genetic background of individuals with a clinical familial hypercholesterolemia phenotype
ανά: Ana Margarida Medeiros, κ.ά.
Έκδοση: (2024-02-01)

Familial hypercholesterolemia: The skin speaks
ανά: Johns T Johnson, κ.ά.
Έκδοση: (2020-01-01)

The Prevalence and Genetic Spectrum of Familial Hypercholesterolemia in Qatar Based on Whole Genome Sequencing of 14,000 Subjects
ανά: Ilhame Diboun, κ.ά.
Έκδοση: (2022-07-01)

Patient experiences align with the familial hypercholesterolemia global call to action
ανά: Laney K. Jones, κ.ά.
Έκδοση: (2022-06-01)

Scientific Disagreement and Evidential Pluralism: Lessons from the Studies on Hypercholesterolemia
ανά: Veli-Pekka Parkkinen, κ.ά.
Έκδοση: (2018-05-01)