Clinical Implications of Monogenic Versus Polygenic Hypercholesterolemia: Long‐Term Response to Treatment, Coronary Atherosclerosis Burden, and Cardiovascular Events

Clinical Implications of Monogenic Versus Polygenic Hypercholesterolemia: Long‐Term Response to Treatment, Coronary Atherosclerosis Burden, and Cardiovascular Events

Background Familial hypercholesterolemia (FH) may arise from deleterious monogenic variants in FH‐causing genes as well as from a polygenic cause. We evaluated the relationships between monogenic FH and polygenic hypercholesterolemia in influencing the long‐term response to therapy and the risk of a...

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Detalhes bibliográficos
Principais autores: Laura D’Erasmo, Ilenia Minicocci, Alessia Di Costanzo, Giovanni Pigna, Daniela Commodari, Fabrizio Ceci, Anna Montali, Francesca Brancato, Ilaria Stanca, Antonio Nicolucci, Andrea Ascione, Nicola Galea, Iacopo Carbone, Marco Francone, Marianna Maranghi, Marcello Arca
Formato: Artigo
Idioma:English
Publicado em: Wiley 2021-05-01
coleção:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Assuntos:
atherosclerosis
cardiovascular disease
genetics
hypercholesterolemia
therapy
Acesso em linha:https://www.ahajournals.org/doi/10.1161/JAHA.120.018932

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