Further evidence for a male-selective genetic association of synapse-associated protein 97 (<it>SAP97</it>) gene with schizophrenia
<p>Abstract</p> <p>Background</p> <p>The synapse-associated protein 97 gene (<it>SAP97</it>) encodes a regulatory scaffold protein for the localization of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (N...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-01-01
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| Series: | Behavioral and Brain Functions |
| Subjects: | |
| Online Access: | http://www.behavioralandbrainfunctions.com/content/8/1/2 |
| Summary: | <p>Abstract</p> <p>Background</p> <p>The synapse-associated protein 97 gene (<it>SAP97</it>) encodes a regulatory scaffold protein for the localization of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) type glutamate receptors. We have recently demonstrated nominally significant associations between <it>SAP97 </it>gene and schizophrenia among Japanese males. The present study aimed to replicate these findings using an independent and larger sample.</p> <p>Methods</p> <p>We investigated seven <it>SAP97 </it>single nucleotide polymorphisms (SNPs) that displayed a significant association with schizophrenia in our preceding study in an independent Japanese population consisting of a total of 393 unrelated patients with schizophrenia (232 males and 161 females) and 393 unrelated control subjects (211 males and 182 females).</p> <p>Results</p> <p>The SNP rs9843659 showed a significant genotypic association with male patients in a recessive model (p = 0.037). The analysis of the combined data from the current and prior studies also demonstrated a significant association of this SNP (p = 0.0039). The meta-analysis for the allele frequency covering the two studies yielded an odds ratio of 1.38.</p> <p>Conclusions</p> <p>The present study replicated the previously reported male-selective genetic association between the <it>SAP97 </it>polymorphism and schizophrenia. These findings further support the possible involvement of the <it>SAP97 </it>gene variation in the susceptibility to schizophrenia in males and in the genetic basis for sex differences in the disorder.</p> |
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| ISSN: | 1744-9081 |