Betulinic Acid Increases the Lifespan of <i>Drosophila melanogaster</i> via Sir2 and FoxO Activation
Betulinic acid (BetA), a triterpenoid derivative found abundantly in the plant kingdom, has emerged as a promising candidate for promoting longevity. Many research studies have shown its antioxidant, anti-inflammatory, antiviral, and anticancer activities, making it an interesting subject for invest...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/3/441 |
| _version_ | 1797318383253848064 |
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| author | Hye-Yeon Lee Kyung-Jin Min |
| author_facet | Hye-Yeon Lee Kyung-Jin Min |
| author_sort | Hye-Yeon Lee |
| collection | DOAJ |
| description | Betulinic acid (BetA), a triterpenoid derivative found abundantly in the plant kingdom, has emerged as a promising candidate for promoting longevity. Many research studies have shown its antioxidant, anti-inflammatory, antiviral, and anticancer activities, making it an interesting subject for investigating its potential influence on lifespan. This study aimed to investigate the effects of BetA on longevity and the mechanisms associated with it using the fruit fly <i>Drosophila melanogaster</i> as the organism model. The results showed that 50 μM BetA supplementation extended the mean lifespan of fruit flies by 13% in males and 6% in females without any adverse effects on their physiology, such as fecundity, feeding rate, or locomotion ability reduction. However, 50 μM BetA supplementation failed to increase the lifespan in mutants lacking functional silent information regulator 2 (Sir2) and Forkhead box O (FoxO)-null, implying that the longevity effect of BetA is related to Sir2 and FoxO activation. Our study contributes to the knowledge in the field of anti-aging research and inspires further investigations into natural compounds such as BetA to enhance organismal healthspan. |
| first_indexed | 2024-03-08T03:50:51Z |
| format | Article |
| id | doaj.art-8998b11331224e64aa07340bf06c24bc |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T03:50:51Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-8998b11331224e64aa07340bf06c24bc2024-02-09T15:20:00ZengMDPI AGNutrients2072-66432024-02-0116344110.3390/nu16030441Betulinic Acid Increases the Lifespan of <i>Drosophila melanogaster</i> via Sir2 and FoxO ActivationHye-Yeon Lee0Kyung-Jin Min1Department of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of KoreaDepartment of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of KoreaBetulinic acid (BetA), a triterpenoid derivative found abundantly in the plant kingdom, has emerged as a promising candidate for promoting longevity. Many research studies have shown its antioxidant, anti-inflammatory, antiviral, and anticancer activities, making it an interesting subject for investigating its potential influence on lifespan. This study aimed to investigate the effects of BetA on longevity and the mechanisms associated with it using the fruit fly <i>Drosophila melanogaster</i> as the organism model. The results showed that 50 μM BetA supplementation extended the mean lifespan of fruit flies by 13% in males and 6% in females without any adverse effects on their physiology, such as fecundity, feeding rate, or locomotion ability reduction. However, 50 μM BetA supplementation failed to increase the lifespan in mutants lacking functional silent information regulator 2 (Sir2) and Forkhead box O (FoxO)-null, implying that the longevity effect of BetA is related to Sir2 and FoxO activation. Our study contributes to the knowledge in the field of anti-aging research and inspires further investigations into natural compounds such as BetA to enhance organismal healthspan.https://www.mdpi.com/2072-6643/16/3/441betulinic acidlifespanphysiologyanti-aging effect<i>Drosophila melanogaster</i> |
| spellingShingle | Hye-Yeon Lee Kyung-Jin Min Betulinic Acid Increases the Lifespan of <i>Drosophila melanogaster</i> via Sir2 and FoxO Activation Nutrients betulinic acid lifespan physiology anti-aging effect <i>Drosophila melanogaster</i> |
| title | Betulinic Acid Increases the Lifespan of <i>Drosophila melanogaster</i> via Sir2 and FoxO Activation |
| title_full | Betulinic Acid Increases the Lifespan of <i>Drosophila melanogaster</i> via Sir2 and FoxO Activation |
| title_fullStr | Betulinic Acid Increases the Lifespan of <i>Drosophila melanogaster</i> via Sir2 and FoxO Activation |
| title_full_unstemmed | Betulinic Acid Increases the Lifespan of <i>Drosophila melanogaster</i> via Sir2 and FoxO Activation |
| title_short | Betulinic Acid Increases the Lifespan of <i>Drosophila melanogaster</i> via Sir2 and FoxO Activation |
| title_sort | betulinic acid increases the lifespan of i drosophila melanogaster i via sir2 and foxo activation |
| topic | betulinic acid lifespan physiology anti-aging effect <i>Drosophila melanogaster</i> |
| url | https://www.mdpi.com/2072-6643/16/3/441 |
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