Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model

Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model

Abstract Background Pulmonary hypertension leads to right ventricular heart failure and ultimately to cardiac cachexia. Cardiac cachexia induces skeletal muscles atrophy and contractile dysfunction. MAFbx and MuRF1 are two key proteins that have been implicated in chronic muscle atrophy of several w...

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Bibliographic Details
Main Authors: Thanh Nguyen, T. Scott Bowen, Antje Augstein, Antje Schauer, Alexander Gasch, Axel Linke, Siegfried Labeit, Volker Adams
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Skeletal Muscle
Subjects:
Cardiac cachexia
Pulmonary hypertension
Muscle atrophy
Myofibrillar proteins
MuRF1 and MuRF2
Muscle energy metabolism
Online Access:http://link.springer.com/article/10.1186/s13395-020-00229-2

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