Microfluidic technologies for cell deformability cytometry
Abstract Microfluidic detection methods for cell deformability cytometry have been regarded as powerful tools for single‐cell analysis of cellular mechanical phenotypes, thus having been widely applied in the fields of cell preparation, separation, clinical diagnostics and so on. Featured with trait...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2022-12-01
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| Series: | Smart Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/SMMD.20220001 |
| _version_ | 1827918075742126080 |
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| author | Hanxu Chen Jiahui Guo Feika Bian Yuanjin Zhao |
| author_facet | Hanxu Chen Jiahui Guo Feika Bian Yuanjin Zhao |
| author_sort | Hanxu Chen |
| collection | DOAJ |
| description | Abstract Microfluidic detection methods for cell deformability cytometry have been regarded as powerful tools for single‐cell analysis of cellular mechanical phenotypes, thus having been widely applied in the fields of cell preparation, separation, clinical diagnostics and so on. Featured with traits like easy operations, low cost and high throughput, such methods have shown great potentials on investigating physiological state and pathological changes during cellular deformation. Herein, a review on the advancements of microfluidic‐based cell deformation cytometry is presented. We discuss several representative microfluidic‐based cell deformability cytometry methods with their frontiers in practical applications. Finally, we analyze the current status and propose the remaining challenges with future perspectives and development directions. |
| first_indexed | 2024-03-13T03:37:35Z |
| format | Article |
| id | doaj.art-899a55aaa20041e996761ba7de3400d0 |
| institution | Directory Open Access Journal |
| issn | 2751-1871 |
| language | English |
| last_indexed | 2024-03-13T03:37:35Z |
| publishDate | 2022-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Smart Medicine |
| spelling | doaj.art-899a55aaa20041e996761ba7de3400d02023-06-23T15:10:31ZengWiley-VCHSmart Medicine2751-18712022-12-0111n/an/a10.1002/SMMD.20220001Microfluidic technologies for cell deformability cytometryHanxu Chen0Jiahui Guo1Feika Bian2Yuanjin Zhao3Department of Clinical Laboratory Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing, Jiangsu ChinaDepartment of Clinical Laboratory Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing, Jiangsu ChinaDepartment of Clinical Laboratory Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing, Jiangsu ChinaDepartment of Clinical Laboratory Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing, Jiangsu ChinaAbstract Microfluidic detection methods for cell deformability cytometry have been regarded as powerful tools for single‐cell analysis of cellular mechanical phenotypes, thus having been widely applied in the fields of cell preparation, separation, clinical diagnostics and so on. Featured with traits like easy operations, low cost and high throughput, such methods have shown great potentials on investigating physiological state and pathological changes during cellular deformation. Herein, a review on the advancements of microfluidic‐based cell deformation cytometry is presented. We discuss several representative microfluidic‐based cell deformability cytometry methods with their frontiers in practical applications. Finally, we analyze the current status and propose the remaining challenges with future perspectives and development directions.https://doi.org/10.1002/SMMD.20220001biomechanicaldeformability cytometryhigh‐throughputmicrofluidicsingle‐cell |
| spellingShingle | Hanxu Chen Jiahui Guo Feika Bian Yuanjin Zhao Microfluidic technologies for cell deformability cytometry Smart Medicine biomechanical deformability cytometry high‐throughput microfluidic single‐cell |
| title | Microfluidic technologies for cell deformability cytometry |
| title_full | Microfluidic technologies for cell deformability cytometry |
| title_fullStr | Microfluidic technologies for cell deformability cytometry |
| title_full_unstemmed | Microfluidic technologies for cell deformability cytometry |
| title_short | Microfluidic technologies for cell deformability cytometry |
| title_sort | microfluidic technologies for cell deformability cytometry |
| topic | biomechanical deformability cytometry high‐throughput microfluidic single‐cell |
| url | https://doi.org/10.1002/SMMD.20220001 |
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