The Relationship Between Laboratory Findings and Bone Mineral Density in Patients with Osteoporosis
Objective:This study was conducted to investigate the relationship between platelet count, mean platelet volume (MPV), platelet distribution width (PDW), C-reactive protein (CRP), platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), systemic immune-inflammation index (SII) and osteopo...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2022-08-01
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| Series: | Türk Osteoporoz Dergisi |
| Subjects: | |
| Online Access: |
http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/the-relationship-between-laboratory-findings-and-b/52660
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| author | Gülseren Dost Sürücü Dilay Eken Gedik |
| author_facet | Gülseren Dost Sürücü Dilay Eken Gedik |
| author_sort | Gülseren Dost Sürücü |
| collection | DOAJ |
| description | Objective:This study was conducted to investigate the relationship between platelet count, mean platelet volume (MPV), platelet distribution width (PDW), C-reactive protein (CRP), platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), systemic immune-inflammation index (SII) and osteoporosis (OP) in postmenopausal women.Materials and Methods:Four hundred eighty two patients who had been in menopause for at least 2 years were included in our study. Hemogram, CRP, thyroid-stimulating hormone (TSH), parathyroid hormone, 25-hydroxyvitamin D3 vitamin and dual-energy X-ray absorptiometry results of all patients were recorded. Two hundred ninety five patients with L2-L4 and/or femoral neck T-scores ≤-2.5 were determined as the OP group, and 192 patients with L2-L4 and/or Femoral neck T-scores ≥-1.0 were determined as the control group. NLR, PLR and SII were calculated and recorded from the hemogram results.Results:The mean age of the OP group was 64.2±8.3 years, and the mean age of the control group was 56.6±8.7. Age and vitamin D3 levels were higher in the OP group than in the control group (p<0.001). Leukocytes, neutrophil and MPV levels were found to be lower in the OP group than in the control group (p<0.005). While the L2-L4 T-score was negatively correlated with age and vitamin D3; leukocytes, MPV, PDW, TSH and CRP were positively correlated. The femoral neck T-score was negatively correlated with age and vitamin D3, whereas it was positively correlated with MPV, PDW, TSH and CRP.Conclusion:Platelet functions and immune system markers are effective in bone mineralization in postmenopausal OP patients. |
| first_indexed | 2024-04-10T12:52:57Z |
| format | Article |
| id | doaj.art-899b9cda226544198d9464b0e0ead4a8 |
| institution | Directory Open Access Journal |
| issn | 2147-2653 |
| language | English |
| last_indexed | 2024-04-10T12:52:57Z |
| publishDate | 2022-08-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Osteoporoz Dergisi |
| spelling | doaj.art-899b9cda226544198d9464b0e0ead4a82023-02-15T16:13:39ZengGalenos YayineviTürk Osteoporoz Dergisi2147-26532022-08-0128214715210.4274/tod.galenos.2022.8108413049054The Relationship Between Laboratory Findings and Bone Mineral Density in Patients with OsteoporosisGülseren Dost Sürücü0Dilay Eken Gedik1 Adıyaman Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Adıyaman, Türkiye Adıyaman Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Adıyaman, Türkiye Objective:This study was conducted to investigate the relationship between platelet count, mean platelet volume (MPV), platelet distribution width (PDW), C-reactive protein (CRP), platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), systemic immune-inflammation index (SII) and osteoporosis (OP) in postmenopausal women.Materials and Methods:Four hundred eighty two patients who had been in menopause for at least 2 years were included in our study. Hemogram, CRP, thyroid-stimulating hormone (TSH), parathyroid hormone, 25-hydroxyvitamin D3 vitamin and dual-energy X-ray absorptiometry results of all patients were recorded. Two hundred ninety five patients with L2-L4 and/or femoral neck T-scores ≤-2.5 were determined as the OP group, and 192 patients with L2-L4 and/or Femoral neck T-scores ≥-1.0 were determined as the control group. NLR, PLR and SII were calculated and recorded from the hemogram results.Results:The mean age of the OP group was 64.2±8.3 years, and the mean age of the control group was 56.6±8.7. Age and vitamin D3 levels were higher in the OP group than in the control group (p<0.001). Leukocytes, neutrophil and MPV levels were found to be lower in the OP group than in the control group (p<0.005). While the L2-L4 T-score was negatively correlated with age and vitamin D3; leukocytes, MPV, PDW, TSH and CRP were positively correlated. The femoral neck T-score was negatively correlated with age and vitamin D3, whereas it was positively correlated with MPV, PDW, TSH and CRP.Conclusion:Platelet functions and immune system markers are effective in bone mineralization in postmenopausal OP patients. http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/the-relationship-between-laboratory-findings-and-b/52660 osteoporosishematological findingsbone mineral density |
| spellingShingle | Gülseren Dost Sürücü Dilay Eken Gedik The Relationship Between Laboratory Findings and Bone Mineral Density in Patients with Osteoporosis Türk Osteoporoz Dergisi osteoporosis hematological findings bone mineral density |
| title | The Relationship Between Laboratory Findings and Bone Mineral Density in Patients with Osteoporosis |
| title_full | The Relationship Between Laboratory Findings and Bone Mineral Density in Patients with Osteoporosis |
| title_fullStr | The Relationship Between Laboratory Findings and Bone Mineral Density in Patients with Osteoporosis |
| title_full_unstemmed | The Relationship Between Laboratory Findings and Bone Mineral Density in Patients with Osteoporosis |
| title_short | The Relationship Between Laboratory Findings and Bone Mineral Density in Patients with Osteoporosis |
| title_sort | relationship between laboratory findings and bone mineral density in patients with osteoporosis |
| topic | osteoporosis hematological findings bone mineral density |
| url |
http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/the-relationship-between-laboratory-findings-and-b/52660
|
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