Formulation and in vitro evaluation of meloxicam as a self-microemulsifying drug delivery system [version 2; peer review: 2 approved]
Background: The nonsteroidal anti-inflammatory medication meloxicam (MLX) belongs to the oxicam family and is used to reduce inflammation and pain. The aim of this study was to improve MLX's dispersibility and stability by producing it as a liquid self-microemulsifying drug delivery system sinc...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2023-05-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/12-315/v2 |
| _version_ | 1797805903945138176 |
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| author | Khalid Kadhem Al-Kinani Saja Abdulkareem Muhammed |
| author_facet | Khalid Kadhem Al-Kinani Saja Abdulkareem Muhammed |
| author_sort | Khalid Kadhem Al-Kinani |
| collection | DOAJ |
| description | Background: The nonsteroidal anti-inflammatory medication meloxicam (MLX) belongs to the oxicam family and is used to reduce inflammation and pain. The aim of this study was to improve MLX's dispersibility and stability by producing it as a liquid self-microemulsifying drug delivery system since it is practically insoluble in water. Methods: Five different formulations were made by adjusting the amounts of propylene glycol, Transcutol P, Tween 80, and oleic acid oil and establishing a pseudo-ternary diagram in ratios of 1:1, 1:2, 1:3, 1:4, and 3:4, respectively. All of the prepared formulations were tested for a variety of properties, including thermodynamic stability, polydispersity index, particle size distributions, dilution resistance, drug contents, dispersibility, in vitro solubility of the drug, and emulsification time. Results: F5 was chosen as the optimal MLX liquid self-microemulsion due to its higher drug content (99.8%), greater in vitro release (100% at 40 min), smaller droplet size (63 nm), lower polydispersity index (PDI) value (0.3), and higher stability (a zeta potential of -81 mV). Conclusions: According to the data provided here, the self-microemulsifying drug delivery system is the most practical method for improving the dispersibility and stability of MLX. |
| first_indexed | 2024-03-13T05:59:11Z |
| format | Article |
| id | doaj.art-899cf88fed704231a8f117ec3e3c744f |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-03-13T05:59:11Z |
| publishDate | 2023-05-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-899cf88fed704231a8f117ec3e3c744f2023-06-13T00:00:00ZengF1000 Research LtdF1000Research2046-14022023-05-0112148205Formulation and in vitro evaluation of meloxicam as a self-microemulsifying drug delivery system [version 2; peer review: 2 approved]Khalid Kadhem Al-Kinani0Saja Abdulkareem Muhammed1https://orcid.org/0000-0001-7708-8651Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Baghdad Governorate, IraqDepartment of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Baghdad Governorate, IraqBackground: The nonsteroidal anti-inflammatory medication meloxicam (MLX) belongs to the oxicam family and is used to reduce inflammation and pain. The aim of this study was to improve MLX's dispersibility and stability by producing it as a liquid self-microemulsifying drug delivery system since it is practically insoluble in water. Methods: Five different formulations were made by adjusting the amounts of propylene glycol, Transcutol P, Tween 80, and oleic acid oil and establishing a pseudo-ternary diagram in ratios of 1:1, 1:2, 1:3, 1:4, and 3:4, respectively. All of the prepared formulations were tested for a variety of properties, including thermodynamic stability, polydispersity index, particle size distributions, dilution resistance, drug contents, dispersibility, in vitro solubility of the drug, and emulsification time. Results: F5 was chosen as the optimal MLX liquid self-microemulsion due to its higher drug content (99.8%), greater in vitro release (100% at 40 min), smaller droplet size (63 nm), lower polydispersity index (PDI) value (0.3), and higher stability (a zeta potential of -81 mV). Conclusions: According to the data provided here, the self-microemulsifying drug delivery system is the most practical method for improving the dispersibility and stability of MLX.https://f1000research.com/articles/12-315/v2Pseudo-ternary phase diagram Dissolution rate SMEDDS Meloxicameng |
| spellingShingle | Khalid Kadhem Al-Kinani Saja Abdulkareem Muhammed Formulation and in vitro evaluation of meloxicam as a self-microemulsifying drug delivery system [version 2; peer review: 2 approved] F1000Research Pseudo-ternary phase diagram Dissolution rate SMEDDS Meloxicam eng |
| title | Formulation and in vitro evaluation of meloxicam as a self-microemulsifying drug delivery system [version 2; peer review: 2 approved] |
| title_full | Formulation and in vitro evaluation of meloxicam as a self-microemulsifying drug delivery system [version 2; peer review: 2 approved] |
| title_fullStr | Formulation and in vitro evaluation of meloxicam as a self-microemulsifying drug delivery system [version 2; peer review: 2 approved] |
| title_full_unstemmed | Formulation and in vitro evaluation of meloxicam as a self-microemulsifying drug delivery system [version 2; peer review: 2 approved] |
| title_short | Formulation and in vitro evaluation of meloxicam as a self-microemulsifying drug delivery system [version 2; peer review: 2 approved] |
| title_sort | formulation and in vitro evaluation of meloxicam as a self microemulsifying drug delivery system version 2 peer review 2 approved |
| topic | Pseudo-ternary phase diagram Dissolution rate SMEDDS Meloxicam eng |
| url | https://f1000research.com/articles/12-315/v2 |
| work_keys_str_mv | AT khalidkadhemalkinani formulationandinvitroevaluationofmeloxicamasaselfmicroemulsifyingdrugdeliverysystemversion2peerreview2approved AT sajaabdulkareemmuhammed formulationandinvitroevaluationofmeloxicamasaselfmicroemulsifyingdrugdeliverysystemversion2peerreview2approved |