Strand Displacement Activity of PrimPol
Human PrimPol is a unique enzyme possessing DNA/RNA primase and DNA polymerase activities. In this work, we demonstrated that PrimPol efficiently fills a 5-nt gap and possesses the conditional strand displacement activity stimulated by Mn<sup>2+</sup> ions and accessory replicative prote...
Main Authors: | Elizaveta O. Boldinova, Ekaterina A. Belousova, Diana I. Gagarinskaya, Ekaterina A. Maltseva, Svetlana N. Khodyreva, Olga I. Lavrik, Alena V. Makarova |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-11-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/23/9027 |
Similar Items
-
Human PrimPol Discrimination against Dideoxynucleotides during Primer Synthesis
by: Gustavo Carvalho, et al.
Published: (2021-09-01) -
PrimPol: A Breakthrough among DNA Replication Enzymes and a Potential New Target for Cancer Therapy
by: Alberto Díaz-Talavera, et al.
Published: (2022-02-01) -
3′dNTP Binding Is Modulated during Primer Synthesis and Translesion by Human PrimPol
by: Cristina Velázquez-Ruiz, et al.
Published: (2023-12-01) -
Human Polymerase δ-Interacting Protein 2 (PolDIP2) Inhibits the Formation of Human Tau Oligomers and Fibrils
by: Kazutoshi Kasho, et al.
Published: (2021-05-01) -
Deletion of the primase-polymerases encoding gene, located in a mobile element in Thermus thermophilus HB27, leads to loss of function mutation of addAB genes
by: Carlos Verdú, et al.
Published: (2022-12-01)