Effects of Acetic Acid Vaginal Gel on Vulvovaginal Candidiasis: A Double Blind Randomized Controlled Trial
Background and purpose: It is estimated that 70–75% of women experience one episode of vulvovaginal candidiasis (VVC) during childbearing age and 40-50% suffer from recurrent VVC. Because of the resistance of Candida species to certain drugs, such as azoles, physicians tend to use complementary or a...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2020-05-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-14622-en.html |
| _version_ | 1797944084060438528 |
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| author | Zahra Rahmani Sara Sadeghi Roghieh Mirzakhani Marzieh Zamaniyan Mahdi Abastabar Jafar Akbari Firoozeh Kermani Mohamad Khademlo Tahereh Shokohi |
| author_facet | Zahra Rahmani Sara Sadeghi Roghieh Mirzakhani Marzieh Zamaniyan Mahdi Abastabar Jafar Akbari Firoozeh Kermani Mohamad Khademlo Tahereh Shokohi |
| author_sort | Zahra Rahmani |
| collection | DOAJ |
| description | Background and purpose: It is estimated that 70–75% of women experience one episode of vulvovaginal candidiasis (VVC) during childbearing age and 40-50% suffer from recurrent VVC. Because of the resistance of Candida species to certain drugs, such as azoles, physicians tend to use complementary or alternative medicine such as vinegar in treatment of VVC. The current study aimed to determine the therapeutic effects of acetic acid vaginal gel on VVC.
Materials and methods: A double-blind randomized clinical trial was done in women (n=41) with VVC in Sari, Iran. The patients were allocated into two treatment groups to receive either 2% acetic acid vaginal gel + 2% acetic acid intravaginal wash + clotrimazole vaginal cream (n=20) or 2% acetic acid intravaginal wash + clotrimazole vaginal cream (n=21) for 10 days. After treatment, clinical symptoms and mycological cure rate were assessed by culture of vaginal secretions. All yeast isolates were identified by molecular method.
Results: Before the intervention, there were no significant differences in signs and symptoms
(P= 0.703), fungal burden rate (low, medium, heavy) (P= 0.092), and causative Candida species (P= 0.188) between the two groups. After treatment, an improvement in symptoms was seen in case group but the difference was not significant (P =0.3512). A significant difference was found between the two groups in mycological cure rate (P= 0.0377). Candida albicans were the most common species causing the disease.
Conclusion: The study showed that acetic acid vaginal gel could have a significant effect on the definitive cure of VVC.
(Clinical Trials Registry Number: IRCT20190309042978N3) |
| first_indexed | 2024-04-10T20:33:00Z |
| format | Article |
| id | doaj.art-899e5d8750704cb381cd4fc04c3c2162 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:33:00Z |
| publishDate | 2020-05-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-899e5d8750704cb381cd4fc04c3c21622023-01-25T05:03:41ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792020-05-01301842839Effects of Acetic Acid Vaginal Gel on Vulvovaginal Candidiasis: A Double Blind Randomized Controlled TrialZahra Rahmani0Sara Sadeghi1Roghieh Mirzakhani2Marzieh Zamaniyan3Mahdi Abastabar4Jafar Akbari5Firoozeh Kermani6Mohamad Khademlo7Tahereh Shokohi8 Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Resident in Gynecology, Department of Obstetrics and Gynecology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran MSc Student in Medical Mycology, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran and Infertility Center, Department of Obstetrics and Gynecology, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Department of Medical Mycology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Professor, Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran PhD Student in Medical Mycology, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Department of Community Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Professor, Department of Medical Mycology, Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: It is estimated that 70–75% of women experience one episode of vulvovaginal candidiasis (VVC) during childbearing age and 40-50% suffer from recurrent VVC. Because of the resistance of Candida species to certain drugs, such as azoles, physicians tend to use complementary or alternative medicine such as vinegar in treatment of VVC. The current study aimed to determine the therapeutic effects of acetic acid vaginal gel on VVC. Materials and methods: A double-blind randomized clinical trial was done in women (n=41) with VVC in Sari, Iran. The patients were allocated into two treatment groups to receive either 2% acetic acid vaginal gel + 2% acetic acid intravaginal wash + clotrimazole vaginal cream (n=20) or 2% acetic acid intravaginal wash + clotrimazole vaginal cream (n=21) for 10 days. After treatment, clinical symptoms and mycological cure rate were assessed by culture of vaginal secretions. All yeast isolates were identified by molecular method. Results: Before the intervention, there were no significant differences in signs and symptoms (P= 0.703), fungal burden rate (low, medium, heavy) (P= 0.092), and causative Candida species (P= 0.188) between the two groups. After treatment, an improvement in symptoms was seen in case group but the difference was not significant (P =0.3512). A significant difference was found between the two groups in mycological cure rate (P= 0.0377). Candida albicans were the most common species causing the disease. Conclusion: The study showed that acetic acid vaginal gel could have a significant effect on the definitive cure of VVC. (Clinical Trials Registry Number: IRCT20190309042978N3)http://jmums.mazums.ac.ir/article-1-14622-en.htmlvulvovaginal candidiasistreatmentacetic acidvaginal washingvaginal gelrandomized controlled clinical trial |
| spellingShingle | Zahra Rahmani Sara Sadeghi Roghieh Mirzakhani Marzieh Zamaniyan Mahdi Abastabar Jafar Akbari Firoozeh Kermani Mohamad Khademlo Tahereh Shokohi Effects of Acetic Acid Vaginal Gel on Vulvovaginal Candidiasis: A Double Blind Randomized Controlled Trial Journal of Mazandaran University of Medical Sciences vulvovaginal candidiasis treatment acetic acid vaginal washing vaginal gel randomized controlled clinical trial |
| title | Effects of Acetic Acid Vaginal Gel on Vulvovaginal Candidiasis: A Double Blind Randomized Controlled Trial |
| title_full | Effects of Acetic Acid Vaginal Gel on Vulvovaginal Candidiasis: A Double Blind Randomized Controlled Trial |
| title_fullStr | Effects of Acetic Acid Vaginal Gel on Vulvovaginal Candidiasis: A Double Blind Randomized Controlled Trial |
| title_full_unstemmed | Effects of Acetic Acid Vaginal Gel on Vulvovaginal Candidiasis: A Double Blind Randomized Controlled Trial |
| title_short | Effects of Acetic Acid Vaginal Gel on Vulvovaginal Candidiasis: A Double Blind Randomized Controlled Trial |
| title_sort | effects of acetic acid vaginal gel on vulvovaginal candidiasis a double blind randomized controlled trial |
| topic | vulvovaginal candidiasis treatment acetic acid vaginal washing vaginal gel randomized controlled clinical trial |
| url | http://jmums.mazums.ac.ir/article-1-14622-en.html |
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