Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study
Atherosclerosis is the major cause of coronary artery disease (CAD), and oxidized LDL (oxLDL) is believed to play a key role in the initiation of the atherosclerotic process. Recent studies show that inflammation and autoimmune reactions are also relevant in atherosclerosis. In this study, we examin...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2011-04-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520409137 |
| _version_ | 1818740404286128128 |
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| author | Qi Chen Steven E. Reis Candace Kammerer Wendy Craig Dennis M. McNamara Richard Holubkov Barry L. Sharaf George Sopko Daniel F. Pauly C. Noel Bairey Merz M. Ilyas Kamboh for the WISE study group |
| author_facet | Qi Chen Steven E. Reis Candace Kammerer Wendy Craig Dennis M. McNamara Richard Holubkov Barry L. Sharaf George Sopko Daniel F. Pauly C. Noel Bairey Merz M. Ilyas Kamboh for the WISE study group |
| author_sort | Qi Chen |
| collection | DOAJ |
| description | Atherosclerosis is the major cause of coronary artery disease (CAD), and oxidized LDL (oxLDL) is believed to play a key role in the initiation of the atherosclerotic process. Recent studies show that inflammation and autoimmune reactions are also relevant in atherosclerosis. In this study, we examined the association of antibodies against oxLDL (anti-oxLDL) with the severity of CAD in 558 Women's Ischemia Syndrome Evaluation (WISE) study samples (465 whites; 93 blacks) determined by coronary stenosis (<20%, 20%–49%, >50% stenosis). We also examined the relationship of anti-oxLDL with serum lipid levels and nine candidate genes including APOE, APOH, APOA5, LPL, LRP1, HL, CETP, PON1, and OLR1. IgM anti-oxLDL levels were significantly higher in the >20% stenosis group than in the ≥20% stenosis group in whites (0.69 ± 0.02 vs. 0.64 ± 0.01, respectively; P = 0.02). IgM anti-oxLDL levels correlated significantly with total cholesterol (r2= 0.01; P = 0.03) and LDL cholesterol (r2= 0.017; P = 0.004) in whites. Multiple regression analysis revealed a suggestive association of LPL/S447X single-nucleotide polymorphism (SNP) with both IgG anti-oxLDL (P = 0.02) and IgM anti-oxLDL (P = 0.07), as well as between IgM anti-oxLDL and the OLR1/3′UTR SNP (P = 0.020). Our data suggest that higher IgM anti-oxLDL levels may provide protection against coronary stenosis and that genetic variation in some candidate genes are determinants of anti-oxLDL levels. |
| first_indexed | 2024-12-18T01:40:11Z |
| format | Article |
| id | doaj.art-899e7e9a98064a3697cac6da8d5a11a7 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-18T01:40:11Z |
| publishDate | 2011-04-01 |
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| series | Journal of Lipid Research |
| spelling | doaj.art-899e7e9a98064a3697cac6da8d5a11a72022-12-21T21:25:21ZengElsevierJournal of Lipid Research0022-22752011-04-01524801807Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation studyQi Chen0Steven E. Reis1Candace Kammerer2Wendy Craig3Dennis M. McNamara4Richard Holubkov5Barry L. Sharaf6George Sopko7Daniel F. Pauly8C. Noel Bairey Merz9M. Ilyas Kamboh for the WISE study group10Department of Human Genetics, and Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PADepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PADepartment of Human Genetics, and Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PAFoundation for Blood Research, Scarborough, MEDepartment of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PAIntermountain Injury Control Research Center, Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, UTDivision of Cardiology, Rhode Island Hospital, Providence, RIDivision of Heart and Vascular Diseases National Heart, Lung, and Blood Institute, Bethesda, MDDivision of Cardiology University of Florida, Gainesville, FLCedars-Sinai Heart Institute Los Angeles, CATo whom correspondence should be addressed. kamboh@pitt.edu; Department of Human Genetics, and Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PAAtherosclerosis is the major cause of coronary artery disease (CAD), and oxidized LDL (oxLDL) is believed to play a key role in the initiation of the atherosclerotic process. Recent studies show that inflammation and autoimmune reactions are also relevant in atherosclerosis. In this study, we examined the association of antibodies against oxLDL (anti-oxLDL) with the severity of CAD in 558 Women's Ischemia Syndrome Evaluation (WISE) study samples (465 whites; 93 blacks) determined by coronary stenosis (<20%, 20%–49%, >50% stenosis). We also examined the relationship of anti-oxLDL with serum lipid levels and nine candidate genes including APOE, APOH, APOA5, LPL, LRP1, HL, CETP, PON1, and OLR1. IgM anti-oxLDL levels were significantly higher in the >20% stenosis group than in the ≥20% stenosis group in whites (0.69 ± 0.02 vs. 0.64 ± 0.01, respectively; P = 0.02). IgM anti-oxLDL levels correlated significantly with total cholesterol (r2= 0.01; P = 0.03) and LDL cholesterol (r2= 0.017; P = 0.004) in whites. Multiple regression analysis revealed a suggestive association of LPL/S447X single-nucleotide polymorphism (SNP) with both IgG anti-oxLDL (P = 0.02) and IgM anti-oxLDL (P = 0.07), as well as between IgM anti-oxLDL and the OLR1/3′UTR SNP (P = 0.020). Our data suggest that higher IgM anti-oxLDL levels may provide protection against coronary stenosis and that genetic variation in some candidate genes are determinants of anti-oxLDL levels.http://www.sciencedirect.com/science/article/pii/S0022227520409137anti-oxLDL antibodiesgeneticslow density lipoprotein |
| spellingShingle | Qi Chen Steven E. Reis Candace Kammerer Wendy Craig Dennis M. McNamara Richard Holubkov Barry L. Sharaf George Sopko Daniel F. Pauly C. Noel Bairey Merz M. Ilyas Kamboh for the WISE study group Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study Journal of Lipid Research anti-oxLDL antibodies genetics low density lipoprotein |
| title | Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study |
| title_full | Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study |
| title_fullStr | Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study |
| title_full_unstemmed | Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study |
| title_short | Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study |
| title_sort | association of anti oxidized ldl and candidate genes with severity of coronary stenosis in the women s ischemia syndrome evaluation study |
| topic | anti-oxLDL antibodies genetics low density lipoprotein |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520409137 |
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