Differences in Thyroid Function and Autoantibodies in the Development of Guillain–Barré Syndrome vs. Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Background: Both Guillain–Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are neurodegenerative and inflammatory demyelination disorders. Sporadic reports showed that the increased levels of thyroid function and autoantibodies are associated with GBS, CIDP,...
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.01018/full |
| _version_ | 1818112700847226880 |
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| author | Yu Tu Xuan Gong Guanwen Zeng Wenyan Zhuo Zhaoxia Li Xueying Yu |
| author_facet | Yu Tu Xuan Gong Guanwen Zeng Wenyan Zhuo Zhaoxia Li Xueying Yu |
| author_sort | Yu Tu |
| collection | DOAJ |
| description | Background: Both Guillain–Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are neurodegenerative and inflammatory demyelination disorders. Sporadic reports showed that the increased levels of thyroid function and autoantibodies are associated with GBS, CIDP, or both, but no systematic study has been reported. We assessed the differences of thyroid function and autoantibodies between GBS and CIDP in a Chinese cohort.Methods: A total of 256 patients were enrolled in this study. 175 clinically confirmed GBS and CIDP patients were selected. Meanwhile, 81 patients hospitalized for diseases other than GBS or CIDP with mild symptoms were enrolled as a control group. Relevant clinical data, including thyroid function, and autoantibody examinations, were collected for statistical analysis.Results: In the comparison of thyroid function and autoantibody parameters, the levels of total thyroxine (TT4), thyroid peroxidase antibody (TPO-Ab), and thyroglobulin antibody (TG-Ab) in the GBS group were all higher than those in the CIDP and Control groups (P < 0.01). The thyroid antibody positive rates in the GBS and CIDP groups were 70.10 and 14.10%, respectively (P < 0.01). In the receiver operating characteristic (ROC) curve analysis, TT4, TPO-Ab, and TG-Ab were higher in the GBS group and lower in the CIDP group (P < 0.01). To achieve a high specificity of 97–99%, the diagnostic cutoff value of TPO-Ab was higher than 133 IU/mL (Sensitivity: 11.34%) or lower than 0.01 IU/mL (Sensitivity: 9.09%), while the diagnostic cutoff value of TG-Ab was higher than 261.1 IU/mL (Sensitivity: 2.06%) or lower than 0.46 IU/mL (Sensitivity: 11.69%). Multivariate logistic regression analysis showed that the differences in TPO-Ab were statistically significant between GBS patients with TPO-Ab was higher than 133 IU/mL and CIDP patients (P < 0.01); the differences in TG-Ab were statistically significant between GBS patients with TG-Ab was higher than 261.1 IU/mL and CIDP patients (P < 0.05).Conclusion: The elevation of thyroid autoantibodies was associated with GBS. TPO-Ab higher than 133 IU/mL or lower than 0.01 IU/mL and TG-Ab higher than 261.1 IU/mL or lower than 0.46 IU/mL had high specificity for differentiating between GBS and CIDP; therefore, TPO-Ab and TG-Ab can be used as biomarkers for the differential diagnosis of GBS and CIDP. |
| first_indexed | 2024-12-11T03:23:07Z |
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| id | doaj.art-89a055e782ef400e94aec7b96e4d2d26 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T03:23:07Z |
| publishDate | 2020-09-01 |
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| spelling | doaj.art-89a055e782ef400e94aec7b96e4d2d262022-12-22T01:22:35ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-09-011110.3389/fneur.2020.01018551633Differences in Thyroid Function and Autoantibodies in the Development of Guillain–Barré Syndrome vs. Chronic Inflammatory Demyelinating PolyradiculoneuropathyYu Tu0Xuan Gong1Guanwen Zeng2Wenyan Zhuo3Zhaoxia Li4Xueying Yu5Zhuhai People's Hospital (Zhuhai Hospital Affiliated With Jinan University), Zhuhai, ChinaZhuhai People's Hospital (Zhuhai Hospital Affiliated With Jinan University), Zhuhai, ChinaZhuhai People's Hospital (Zhuhai Hospital Affiliated With Jinan University), Zhuhai, ChinaZhuhai People's Hospital (Zhuhai Hospital Affiliated With Jinan University), Zhuhai, ChinaBeijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBackground: Both Guillain–Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are neurodegenerative and inflammatory demyelination disorders. Sporadic reports showed that the increased levels of thyroid function and autoantibodies are associated with GBS, CIDP, or both, but no systematic study has been reported. We assessed the differences of thyroid function and autoantibodies between GBS and CIDP in a Chinese cohort.Methods: A total of 256 patients were enrolled in this study. 175 clinically confirmed GBS and CIDP patients were selected. Meanwhile, 81 patients hospitalized for diseases other than GBS or CIDP with mild symptoms were enrolled as a control group. Relevant clinical data, including thyroid function, and autoantibody examinations, were collected for statistical analysis.Results: In the comparison of thyroid function and autoantibody parameters, the levels of total thyroxine (TT4), thyroid peroxidase antibody (TPO-Ab), and thyroglobulin antibody (TG-Ab) in the GBS group were all higher than those in the CIDP and Control groups (P < 0.01). The thyroid antibody positive rates in the GBS and CIDP groups were 70.10 and 14.10%, respectively (P < 0.01). In the receiver operating characteristic (ROC) curve analysis, TT4, TPO-Ab, and TG-Ab were higher in the GBS group and lower in the CIDP group (P < 0.01). To achieve a high specificity of 97–99%, the diagnostic cutoff value of TPO-Ab was higher than 133 IU/mL (Sensitivity: 11.34%) or lower than 0.01 IU/mL (Sensitivity: 9.09%), while the diagnostic cutoff value of TG-Ab was higher than 261.1 IU/mL (Sensitivity: 2.06%) or lower than 0.46 IU/mL (Sensitivity: 11.69%). Multivariate logistic regression analysis showed that the differences in TPO-Ab were statistically significant between GBS patients with TPO-Ab was higher than 133 IU/mL and CIDP patients (P < 0.01); the differences in TG-Ab were statistically significant between GBS patients with TG-Ab was higher than 261.1 IU/mL and CIDP patients (P < 0.05).Conclusion: The elevation of thyroid autoantibodies was associated with GBS. TPO-Ab higher than 133 IU/mL or lower than 0.01 IU/mL and TG-Ab higher than 261.1 IU/mL or lower than 0.46 IU/mL had high specificity for differentiating between GBS and CIDP; therefore, TPO-Ab and TG-Ab can be used as biomarkers for the differential diagnosis of GBS and CIDP.https://www.frontiersin.org/article/10.3389/fneur.2020.01018/fullGuillain–Barré syndromechronic inflammatory demyelinating polyradiculoneuropathythyroid peroxidase antibodythyroglobulin antibodyserum total thyroxine |
| spellingShingle | Yu Tu Xuan Gong Guanwen Zeng Wenyan Zhuo Zhaoxia Li Xueying Yu Differences in Thyroid Function and Autoantibodies in the Development of Guillain–Barré Syndrome vs. Chronic Inflammatory Demyelinating Polyradiculoneuropathy Frontiers in Neurology Guillain–Barré syndrome chronic inflammatory demyelinating polyradiculoneuropathy thyroid peroxidase antibody thyroglobulin antibody serum total thyroxine |
| title | Differences in Thyroid Function and Autoantibodies in the Development of Guillain–Barré Syndrome vs. Chronic Inflammatory Demyelinating Polyradiculoneuropathy |
| title_full | Differences in Thyroid Function and Autoantibodies in the Development of Guillain–Barré Syndrome vs. Chronic Inflammatory Demyelinating Polyradiculoneuropathy |
| title_fullStr | Differences in Thyroid Function and Autoantibodies in the Development of Guillain–Barré Syndrome vs. Chronic Inflammatory Demyelinating Polyradiculoneuropathy |
| title_full_unstemmed | Differences in Thyroid Function and Autoantibodies in the Development of Guillain–Barré Syndrome vs. Chronic Inflammatory Demyelinating Polyradiculoneuropathy |
| title_short | Differences in Thyroid Function and Autoantibodies in the Development of Guillain–Barré Syndrome vs. Chronic Inflammatory Demyelinating Polyradiculoneuropathy |
| title_sort | differences in thyroid function and autoantibodies in the development of guillain barre syndrome vs chronic inflammatory demyelinating polyradiculoneuropathy |
| topic | Guillain–Barré syndrome chronic inflammatory demyelinating polyradiculoneuropathy thyroid peroxidase antibody thyroglobulin antibody serum total thyroxine |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.01018/full |
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