Translational control in plant antiviral immunity
Abstract Due to the limited coding capacity of viral genomes, plant viruses depend extensively on the host cell machinery to support the viral life cycle and, thereby, interact with a large number of host proteins during infection. Within this context, as plant viruses do not harbor translation-requ...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017005002105&lng=en&tlng=en |
| _version_ | 1828776150509289472 |
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| author | João Paulo B. Machado Iara P. Calil Anésia A. Santos Elizabeth P.B. Fontes |
| author_facet | João Paulo B. Machado Iara P. Calil Anésia A. Santos Elizabeth P.B. Fontes |
| author_sort | João Paulo B. Machado |
| collection | DOAJ |
| description | Abstract Due to the limited coding capacity of viral genomes, plant viruses depend extensively on the host cell machinery to support the viral life cycle and, thereby, interact with a large number of host proteins during infection. Within this context, as plant viruses do not harbor translation-required components, they have developed several strategies to subvert the host protein synthesis machinery to produce rapidly and efficiently the viral proteins. As a countermeasure against infection, plants have evolved defense mechanisms that impair viral infections. Among them, the host-mediated translational suppression has been characterized as an efficient mean to restrict infection. To specifically suppress translation of viral mRNAs, plants can deploy susceptible recessive resistance genes, which encode translation initiation factors from the eIF4E and eIF4G family and are required for viral mRNA translation and multiplication. Additionally, recent evidence has demonstrated that, alternatively to the cleavage of viral RNA targets, host cells can suppress viral protein translation to silence viral RNA. Finally, a novel strategy of plant antiviral defense based on suppression of host global translation, which is mediated by the transmembrane immune receptor NIK1 (nuclear shuttle protein (NSP)-Interacting Kinase1), is discussed in this review. |
| first_indexed | 2024-12-11T15:53:23Z |
| format | Article |
| id | doaj.art-89a08f89e49c4bc18c83918050f74d51 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-12-11T15:53:23Z |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-89a08f89e49c4bc18c83918050f74d512022-12-22T00:59:30ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-4685010.1590/1678-4685-gmb-2016-0092S1415-47572017005002105Translational control in plant antiviral immunityJoão Paulo B. MachadoIara P. CalilAnésia A. SantosElizabeth P.B. FontesAbstract Due to the limited coding capacity of viral genomes, plant viruses depend extensively on the host cell machinery to support the viral life cycle and, thereby, interact with a large number of host proteins during infection. Within this context, as plant viruses do not harbor translation-required components, they have developed several strategies to subvert the host protein synthesis machinery to produce rapidly and efficiently the viral proteins. As a countermeasure against infection, plants have evolved defense mechanisms that impair viral infections. Among them, the host-mediated translational suppression has been characterized as an efficient mean to restrict infection. To specifically suppress translation of viral mRNAs, plants can deploy susceptible recessive resistance genes, which encode translation initiation factors from the eIF4E and eIF4G family and are required for viral mRNA translation and multiplication. Additionally, recent evidence has demonstrated that, alternatively to the cleavage of viral RNA targets, host cells can suppress viral protein translation to silence viral RNA. Finally, a novel strategy of plant antiviral defense based on suppression of host global translation, which is mediated by the transmembrane immune receptor NIK1 (nuclear shuttle protein (NSP)-Interacting Kinase1), is discussed in this review.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017005002105&lng=en&tlng=enTranslation suppressionrecessive resistance genesArgonauteNSP-Interacting KinaseNIK |
| spellingShingle | João Paulo B. Machado Iara P. Calil Anésia A. Santos Elizabeth P.B. Fontes Translational control in plant antiviral immunity Genetics and Molecular Biology Translation suppression recessive resistance genes Argonaute NSP-Interacting Kinase NIK |
| title | Translational control in plant antiviral immunity |
| title_full | Translational control in plant antiviral immunity |
| title_fullStr | Translational control in plant antiviral immunity |
| title_full_unstemmed | Translational control in plant antiviral immunity |
| title_short | Translational control in plant antiviral immunity |
| title_sort | translational control in plant antiviral immunity |
| topic | Translation suppression recessive resistance genes Argonaute NSP-Interacting Kinase NIK |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017005002105&lng=en&tlng=en |
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