Development of Pharmacological Strategies with Therapeutic Potential in Ischemic Stroke
Acute ischemic stroke constitutes a health challenge with great social impact due to its high incidence, with the social dependency that it generates being an important source of inequality. The lack of treatments serving as effective neuroprotective therapies beyond thrombolysis and thrombectomy is...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/12/2102 |
| _version_ | 1797382248863891456 |
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| author | Alejandro Escobar-Peso Emma Martínez-Alonso Jaime Masjuan Alberto Alcázar |
| author_facet | Alejandro Escobar-Peso Emma Martínez-Alonso Jaime Masjuan Alberto Alcázar |
| author_sort | Alejandro Escobar-Peso |
| collection | DOAJ |
| description | Acute ischemic stroke constitutes a health challenge with great social impact due to its high incidence, with the social dependency that it generates being an important source of inequality. The lack of treatments serving as effective neuroprotective therapies beyond thrombolysis and thrombectomy is presented as a need. With this goal in mind, our research group’s collaborative studies into cerebral ischemia and subsequent reperfusion concluded that there is a need to develop compounds with antioxidant and radical scavenger features. In this review, we summarize the path taken toward the identification of lead compounds as potential candidates for the treatment of acute ischemic stroke. Evaluations of the antioxidant capacity, neuroprotection of primary neuronal cultures and in vivo experimental models of cerebral ischemia, including neurological deficit score assessments, are conducted to characterize the biological efficacy of the various neuroprotective compounds developed. Moreover, the initial results in preclinical development, including dose–response studies, the therapeutic window, the long-term neuroprotective effect and in vivo antioxidant evaluation, are reported. The results prompt these compounds for clinical trials and are encouraging regarding new drug developments aimed at a successful therapy for ischemic stroke. |
| first_indexed | 2024-03-08T21:02:42Z |
| format | Article |
| id | doaj.art-89a1b60ff32741968535e80ccfd00415 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-08T21:02:42Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-89a1b60ff32741968535e80ccfd004152023-12-22T13:48:32ZengMDPI AGAntioxidants2076-39212023-12-011212210210.3390/antiox12122102Development of Pharmacological Strategies with Therapeutic Potential in Ischemic StrokeAlejandro Escobar-Peso0Emma Martínez-Alonso1Jaime Masjuan2Alberto Alcázar3Department of Research, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainDepartment of Research, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainDepartment of Neurology, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainDepartment of Research, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainAcute ischemic stroke constitutes a health challenge with great social impact due to its high incidence, with the social dependency that it generates being an important source of inequality. The lack of treatments serving as effective neuroprotective therapies beyond thrombolysis and thrombectomy is presented as a need. With this goal in mind, our research group’s collaborative studies into cerebral ischemia and subsequent reperfusion concluded that there is a need to develop compounds with antioxidant and radical scavenger features. In this review, we summarize the path taken toward the identification of lead compounds as potential candidates for the treatment of acute ischemic stroke. Evaluations of the antioxidant capacity, neuroprotection of primary neuronal cultures and in vivo experimental models of cerebral ischemia, including neurological deficit score assessments, are conducted to characterize the biological efficacy of the various neuroprotective compounds developed. Moreover, the initial results in preclinical development, including dose–response studies, the therapeutic window, the long-term neuroprotective effect and in vivo antioxidant evaluation, are reported. The results prompt these compounds for clinical trials and are encouraging regarding new drug developments aimed at a successful therapy for ischemic stroke.https://www.mdpi.com/2076-3921/12/12/2102antioxidant compoundsischemic strokeneuroprotectionoxidative stress |
| spellingShingle | Alejandro Escobar-Peso Emma Martínez-Alonso Jaime Masjuan Alberto Alcázar Development of Pharmacological Strategies with Therapeutic Potential in Ischemic Stroke Antioxidants antioxidant compounds ischemic stroke neuroprotection oxidative stress |
| title | Development of Pharmacological Strategies with Therapeutic Potential in Ischemic Stroke |
| title_full | Development of Pharmacological Strategies with Therapeutic Potential in Ischemic Stroke |
| title_fullStr | Development of Pharmacological Strategies with Therapeutic Potential in Ischemic Stroke |
| title_full_unstemmed | Development of Pharmacological Strategies with Therapeutic Potential in Ischemic Stroke |
| title_short | Development of Pharmacological Strategies with Therapeutic Potential in Ischemic Stroke |
| title_sort | development of pharmacological strategies with therapeutic potential in ischemic stroke |
| topic | antioxidant compounds ischemic stroke neuroprotection oxidative stress |
| url | https://www.mdpi.com/2076-3921/12/12/2102 |
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