The purified extract of steamed Panax ginseng protects cardiomyocyte from ischemic injury via caveolin-1 phosphorylation-mediating calcium influx

The purified extract of steamed Panax ginseng protects cardiomyocyte from ischemic injury via caveolin-1 phosphorylation-mediating calcium influx

Background: Caveolin-1, the scaffolding protein of cholesterol-rich invaginations, plays an important role in store-operated Ca2+ influx and its phosphorylation at Tyr14 (p-caveolin-1) is vital to mobilize protection against myocardial ischemia (MI) injury. SOCE, comprising STIM1, ORAI1 and TRPC1, c...

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Bibliographic Details
Main Authors: Hai-Xia Li, Yan Ma, Yu-Xiao Yan, Xin-Ke Zhai, Meng-Yu Xin, Tian Wang, Dong-Cao Xu, Yu-Tong Song, Chun-Dong Song, Cheng-Xue Pan
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Journal of Ginseng Research
Subjects:
Panax ginseng
myocardial ischemia
caveolin-1
calcium overload
SOCE
Online Access:http://www.sciencedirect.com/science/article/pii/S1226845323000775

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