Case series of idiopathic intracranial hypertension in three patients with immune-complex glomerulonephritis
Abstract Background Idiopathic intracranial hypertension (IIH) is defined by an increased cerebrospinal fluid pressure in the absence of inflammation, structural obstructions, or mass lesions. Although the underlying pathogenesis of IIH is not fully understood, associations with specific risk factor...
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-021-02297-3 |
| _version_ | 1818649768422801408 |
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| author | Felix Fischbach Anne Deborah Scholz-Hehn Christian Gerloff Monika Pötter-Nerger |
| author_facet | Felix Fischbach Anne Deborah Scholz-Hehn Christian Gerloff Monika Pötter-Nerger |
| author_sort | Felix Fischbach |
| collection | DOAJ |
| description | Abstract Background Idiopathic intracranial hypertension (IIH) is defined by an increased cerebrospinal fluid pressure in the absence of inflammation, structural obstructions, or mass lesions. Although the underlying pathogenesis of IIH is not fully understood, associations with specific risk factors as obesity, obstruction of cerebral venous sinuses, medications, endocrine or systemic conditions and chronic kidney disease have been described. Immune-complex glomerulonephritis as IgA-nephropathy is a frequent cause of chronic kidney failure, which was reported previously in one IIH patient. To date, there is no knowledge about the variable relation of immune-complex nephritis, kidney function and the course of IIH. Case presentation We report three cases (two females) of concurrent diagnosis of IIH and immune-complex glomerulonephritis. All patients presented with typical IIH symptoms of headache and visual disturbances. Two patients had been diagnosed with IgA-nephropathy only few weeks prior to IIH diagnosis. The third patient had been diagnosed earlier with terminal kidney failure due to a cryoglobulin glomerulonephritis. Conclusion We propose a possible link between renal deposition of immune-complexes and increased cerebrospinal fluid pressure. Pathophysiological hypotheses and clinical implications are discussed. We recommend clinical awareness and further systematic research to obtain more information on the association of IIH and immune-complex glomerulonephritis. |
| first_indexed | 2024-12-17T01:39:34Z |
| format | Article |
| id | doaj.art-89a3833de663474f80394865032b9563 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-17T01:39:34Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-89a3833de663474f80394865032b95632022-12-21T22:08:20ZengBMCBMC Neurology1471-23772021-07-012111610.1186/s12883-021-02297-3Case series of idiopathic intracranial hypertension in three patients with immune-complex glomerulonephritisFelix Fischbach0Anne Deborah Scholz-Hehn1Christian Gerloff2Monika Pötter-Nerger3Department of Neurology, University Medical Center Hamburg-EppendorfDepartment of Neurology, University Medical Center Hamburg-EppendorfDepartment of Neurology, University Medical Center Hamburg-EppendorfDepartment of Neurology, University Medical Center Hamburg-EppendorfAbstract Background Idiopathic intracranial hypertension (IIH) is defined by an increased cerebrospinal fluid pressure in the absence of inflammation, structural obstructions, or mass lesions. Although the underlying pathogenesis of IIH is not fully understood, associations with specific risk factors as obesity, obstruction of cerebral venous sinuses, medications, endocrine or systemic conditions and chronic kidney disease have been described. Immune-complex glomerulonephritis as IgA-nephropathy is a frequent cause of chronic kidney failure, which was reported previously in one IIH patient. To date, there is no knowledge about the variable relation of immune-complex nephritis, kidney function and the course of IIH. Case presentation We report three cases (two females) of concurrent diagnosis of IIH and immune-complex glomerulonephritis. All patients presented with typical IIH symptoms of headache and visual disturbances. Two patients had been diagnosed with IgA-nephropathy only few weeks prior to IIH diagnosis. The third patient had been diagnosed earlier with terminal kidney failure due to a cryoglobulin glomerulonephritis. Conclusion We propose a possible link between renal deposition of immune-complexes and increased cerebrospinal fluid pressure. Pathophysiological hypotheses and clinical implications are discussed. We recommend clinical awareness and further systematic research to obtain more information on the association of IIH and immune-complex glomerulonephritis.https://doi.org/10.1186/s12883-021-02297-3Idiopathic intracranial hypertensionPseudotumor cerebriImmune-complex glomerulonephritisNephropathyIgA nephropathyCase report |
| spellingShingle | Felix Fischbach Anne Deborah Scholz-Hehn Christian Gerloff Monika Pötter-Nerger Case series of idiopathic intracranial hypertension in three patients with immune-complex glomerulonephritis BMC Neurology Idiopathic intracranial hypertension Pseudotumor cerebri Immune-complex glomerulonephritis Nephropathy IgA nephropathy Case report |
| title | Case series of idiopathic intracranial hypertension in three patients with immune-complex glomerulonephritis |
| title_full | Case series of idiopathic intracranial hypertension in three patients with immune-complex glomerulonephritis |
| title_fullStr | Case series of idiopathic intracranial hypertension in three patients with immune-complex glomerulonephritis |
| title_full_unstemmed | Case series of idiopathic intracranial hypertension in three patients with immune-complex glomerulonephritis |
| title_short | Case series of idiopathic intracranial hypertension in three patients with immune-complex glomerulonephritis |
| title_sort | case series of idiopathic intracranial hypertension in three patients with immune complex glomerulonephritis |
| topic | Idiopathic intracranial hypertension Pseudotumor cerebri Immune-complex glomerulonephritis Nephropathy IgA nephropathy Case report |
| url | https://doi.org/10.1186/s12883-021-02297-3 |
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