Behcet's disease: demographic and genetic aspects (a literature review)
A review of literature focused on Behcet's disease (BD) is presented. BD is systemic vasculitis of unknown etiology affecting multiple organs. BD is endemic in the countries along the Eastern Mediterranean coast and the areas of Central and East Asia. We report the data on BD prevalence in diff...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2014-03-01
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| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/511 |
| _version_ | 1797876838926647296 |
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| author | Fatima Ismailovna Izmailova Z S Alekberova |
| author_facet | Fatima Ismailovna Izmailova Z S Alekberova |
| author_sort | Fatima Ismailovna Izmailova |
| collection | DOAJ |
| description | A review of literature focused on Behcet's disease (BD) is presented. BD is systemic vasculitis of unknown etiology affecting multiple organs. BD is endemic in the countries along the Eastern Mediterranean coast and the areas of Central and East Asia. We report the data on BD prevalence in different regions and the effect of population migration on BD incidence rate. Patients were found to be younger at the onset of the disease in Arab countries, Turkey, and Israel (19.9; 25.6; and 26 years, respectively) than those in East Asia countries (31.7 years). We summarized the data attesting to the genetic susceptibility in BD patients: HLA B51-positive individuals, family aggregation observed when studying twins, etc. The clinical polymorphism in BD patients was shown to depend on their region of residence and ethnicity. The data of a series of large cohort studies are reported; the frequencies of the international criteria of BD in the US and Japanese patients are compared in these studies. The question regarding the need for cross-sectional population-based and case-control studies using the standard criteria and clear definition of ethnicity is brought up in some publications. |
| first_indexed | 2024-04-10T02:07:38Z |
| format | Article |
| id | doaj.art-89a4470eef704eb796a779ac27989a12 |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2024-04-10T02:07:38Z |
| publishDate | 2014-03-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-89a4470eef704eb796a779ac27989a122023-03-13T08:39:23ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2014-03-0181535810.14412/1996-7012-2014-1-53-581816Behcet's disease: demographic and genetic aspects (a literature review)Fatima Ismailovna Izmailova0Z S Alekberova1Факультет повышения квалификации и профессиональной переподготовки специалистов ГБОУ ВПО «Дагестанская государственная медицинская академия» Минздрава России, Махачкала, Республика Дагестан; 367000, Республика Дагестан, Махачкала, пл. Ленина, 1ФГБУ «Научно-исследовательский инсти- тут ревматологии им. В.А. Насоновой» РАМН, Москва, Россия; 115522, Москва, Каширское ш., 34AA review of literature focused on Behcet's disease (BD) is presented. BD is systemic vasculitis of unknown etiology affecting multiple organs. BD is endemic in the countries along the Eastern Mediterranean coast and the areas of Central and East Asia. We report the data on BD prevalence in different regions and the effect of population migration on BD incidence rate. Patients were found to be younger at the onset of the disease in Arab countries, Turkey, and Israel (19.9; 25.6; and 26 years, respectively) than those in East Asia countries (31.7 years). We summarized the data attesting to the genetic susceptibility in BD patients: HLA B51-positive individuals, family aggregation observed when studying twins, etc. The clinical polymorphism in BD patients was shown to depend on their region of residence and ethnicity. The data of a series of large cohort studies are reported; the frequencies of the international criteria of BD in the US and Japanese patients are compared in these studies. The question regarding the need for cross-sectional population-based and case-control studies using the standard criteria and clear definition of ethnicity is brought up in some publications.https://mrj.ima-press.net/mrj/article/view/511болезнь бехчетаэпидемиологиядемографиягенетика (hla b51), клинический полиморфизм |
| spellingShingle | Fatima Ismailovna Izmailova Z S Alekberova Behcet's disease: demographic and genetic aspects (a literature review) Современная ревматология болезнь бехчета эпидемиология демография генетика (hla b51), клинический полиморфизм |
| title | Behcet's disease: demographic and genetic aspects (a literature review) |
| title_full | Behcet's disease: demographic and genetic aspects (a literature review) |
| title_fullStr | Behcet's disease: demographic and genetic aspects (a literature review) |
| title_full_unstemmed | Behcet's disease: demographic and genetic aspects (a literature review) |
| title_short | Behcet's disease: demographic and genetic aspects (a literature review) |
| title_sort | behcet s disease demographic and genetic aspects a literature review |
| topic | болезнь бехчета эпидемиология демография генетика (hla b51), клинический полиморфизм |
| url | https://mrj.ima-press.net/mrj/article/view/511 |
| work_keys_str_mv | AT fatimaismailovnaizmailova behcetsdiseasedemographicandgeneticaspectsaliteraturereview AT zsalekberova behcetsdiseasedemographicandgeneticaspectsaliteraturereview |