Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex
Interorganelle membrane contact sites between the endoplasmic reticulum and mitochondria can be mediated with the ER-mitochondria encounter structure (ERMES) complex, though precise regulation is unclear. Here, the authors report that the number of ERMES foci is regulated by the previously uncharact...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20866-x |
| _version_ | 1818428964233805824 |
|---|---|
| author | Faiz Rasul Fan Zheng Fenfen Dong Jiajia He Ling Liu Wenyue Liu Javairia Yousuf Cheema Wenfan Wei Chuanhai Fu |
| author_facet | Faiz Rasul Fan Zheng Fenfen Dong Jiajia He Ling Liu Wenyue Liu Javairia Yousuf Cheema Wenfan Wei Chuanhai Fu |
| author_sort | Faiz Rasul |
| collection | DOAJ |
| description | Interorganelle membrane contact sites between the endoplasmic reticulum and mitochondria can be mediated with the ER-mitochondria encounter structure (ERMES) complex, though precise regulation is unclear. Here, the authors report that the number of ERMES foci is regulated by the previously uncharacterized mitochondrial membrane protein Emr1. |
| first_indexed | 2024-12-14T15:09:59Z |
| format | Article |
| id | doaj.art-89a4da49fba64046b10a14698cbfdd0f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T15:09:59Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-89a4da49fba64046b10a14698cbfdd0f2022-12-21T22:56:35ZengNature PortfolioNature Communications2041-17232021-01-0112111410.1038/s41467-020-20866-xEmr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complexFaiz Rasul0Fan Zheng1Fenfen Dong2Jiajia He3Ling Liu4Wenyue Liu5Javairia Yousuf Cheema6Wenfan Wei7Chuanhai Fu8Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaInterorganelle membrane contact sites between the endoplasmic reticulum and mitochondria can be mediated with the ER-mitochondria encounter structure (ERMES) complex, though precise regulation is unclear. Here, the authors report that the number of ERMES foci is regulated by the previously uncharacterized mitochondrial membrane protein Emr1.https://doi.org/10.1038/s41467-020-20866-x |
| spellingShingle | Faiz Rasul Fan Zheng Fenfen Dong Jiajia He Ling Liu Wenyue Liu Javairia Yousuf Cheema Wenfan Wei Chuanhai Fu Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex Nature Communications |
| title | Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex |
| title_full | Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex |
| title_fullStr | Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex |
| title_full_unstemmed | Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex |
| title_short | Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex |
| title_sort | emr1 regulates the number of foci of the endoplasmic reticulum mitochondria encounter structure complex |
| url | https://doi.org/10.1038/s41467-020-20866-x |
| work_keys_str_mv | AT faizrasul emr1regulatesthenumberoffocioftheendoplasmicreticulummitochondriaencounterstructurecomplex AT fanzheng emr1regulatesthenumberoffocioftheendoplasmicreticulummitochondriaencounterstructurecomplex AT fenfendong emr1regulatesthenumberoffocioftheendoplasmicreticulummitochondriaencounterstructurecomplex AT jiajiahe emr1regulatesthenumberoffocioftheendoplasmicreticulummitochondriaencounterstructurecomplex AT lingliu emr1regulatesthenumberoffocioftheendoplasmicreticulummitochondriaencounterstructurecomplex AT wenyueliu emr1regulatesthenumberoffocioftheendoplasmicreticulummitochondriaencounterstructurecomplex AT javairiayousufcheema emr1regulatesthenumberoffocioftheendoplasmicreticulummitochondriaencounterstructurecomplex AT wenfanwei emr1regulatesthenumberoffocioftheendoplasmicreticulummitochondriaencounterstructurecomplex AT chuanhaifu emr1regulatesthenumberoffocioftheendoplasmicreticulummitochondriaencounterstructurecomplex |