Using Fractal Dimension Analysis with the Desikan–Killiany Atlas to Assess the Effects of Normal Aging on Subregional Cortex Alterations in Adulthood
Normal aging is associated with functional and structural alterations in the human brain. The effects of normal aging and gender on morphological changes in specific regions of the brain are unknown. The fractal dimension (FD) can be a quantitative measure of cerebral folding. In this study, we used...
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MDPI AG
2021-01-01
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| Online Access: | https://www.mdpi.com/2076-3425/11/1/107 |
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| author | Chi-Wen Jao Chi Ieong Lau Li-Ming Lien Yuh-Feng Tsai Kuang-En Chu Chen-Yu Hsiao Jiann-Horng Yeh Yu-Te Wu |
| author_facet | Chi-Wen Jao Chi Ieong Lau Li-Ming Lien Yuh-Feng Tsai Kuang-En Chu Chen-Yu Hsiao Jiann-Horng Yeh Yu-Te Wu |
| author_sort | Chi-Wen Jao |
| collection | DOAJ |
| description | Normal aging is associated with functional and structural alterations in the human brain. The effects of normal aging and gender on morphological changes in specific regions of the brain are unknown. The fractal dimension (FD) can be a quantitative measure of cerebral folding. In this study, we used 3D-FD analysis with the Desikan–Killiany (DK) atlas to assess subregional morphological changes in adulthood. A total of 258 participants (112 women and 146 men) aged 30–85 years participated in this study. Participants in the middle-age group exhibited a decreased FD in the lateral frontal lobes, which then spread to the temporal and parietal lobes. Men exhibited an earlier and more significant decrease in FD values, mainly in the right frontal and left parietal lobes. Men exhibited more of a decrease in FD values in the subregions on the left than those in the right, whereas women exhibited more of a decrease in the lateral subregions. Older men were at a higher risk of developing mild cognitive impairment (MCI) and exhibited age-related memory decline earlier than women. Our FD analysis using the DK atlas-based prediagnosis may provide a suitable tool for assessing normal aging and neurodegeneration between groups or in individual patients. |
| first_indexed | 2024-03-09T04:44:05Z |
| format | Article |
| id | doaj.art-89a576920e074366a27b6520b16094b6 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T04:44:05Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-89a576920e074366a27b6520b16094b62023-12-03T13:17:36ZengMDPI AGBrain Sciences2076-34252021-01-0111110710.3390/brainsci11010107Using Fractal Dimension Analysis with the Desikan–Killiany Atlas to Assess the Effects of Normal Aging on Subregional Cortex Alterations in AdulthoodChi-Wen Jao0Chi Ieong Lau1Li-Ming Lien2Yuh-Feng Tsai3Kuang-En Chu4Chen-Yu Hsiao5Jiann-Horng Yeh6Yu-Te Wu7Institute of Biophotonics, National Yang-Ming University, Taipei 112, TaiwanInstitute of Biophotonics, National Yang-Ming University, Taipei 112, TaiwanDepartment of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, TaiwanSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 242, TaiwanDepartment of Gastroenterology, Shin Kong Wo Ho-Su Memorial Hospital, Taipei 111, TaiwanDepartment of Diagnostic Radiology, Shin Kong Wu Ho Su Memorial Hospital, Taipei 111, TaiwanSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 242, TaiwanInstitute of Biophotonics, National Yang-Ming University, Taipei 112, TaiwanNormal aging is associated with functional and structural alterations in the human brain. The effects of normal aging and gender on morphological changes in specific regions of the brain are unknown. The fractal dimension (FD) can be a quantitative measure of cerebral folding. In this study, we used 3D-FD analysis with the Desikan–Killiany (DK) atlas to assess subregional morphological changes in adulthood. A total of 258 participants (112 women and 146 men) aged 30–85 years participated in this study. Participants in the middle-age group exhibited a decreased FD in the lateral frontal lobes, which then spread to the temporal and parietal lobes. Men exhibited an earlier and more significant decrease in FD values, mainly in the right frontal and left parietal lobes. Men exhibited more of a decrease in FD values in the subregions on the left than those in the right, whereas women exhibited more of a decrease in the lateral subregions. Older men were at a higher risk of developing mild cognitive impairment (MCI) and exhibited age-related memory decline earlier than women. Our FD analysis using the DK atlas-based prediagnosis may provide a suitable tool for assessing normal aging and neurodegeneration between groups or in individual patients.https://www.mdpi.com/2076-3425/11/1/107normal agingfractal dimensionDesikan–Killiany Atlasprediagnosis |
| spellingShingle | Chi-Wen Jao Chi Ieong Lau Li-Ming Lien Yuh-Feng Tsai Kuang-En Chu Chen-Yu Hsiao Jiann-Horng Yeh Yu-Te Wu Using Fractal Dimension Analysis with the Desikan–Killiany Atlas to Assess the Effects of Normal Aging on Subregional Cortex Alterations in Adulthood Brain Sciences normal aging fractal dimension Desikan–Killiany Atlas prediagnosis |
| title | Using Fractal Dimension Analysis with the Desikan–Killiany Atlas to Assess the Effects of Normal Aging on Subregional Cortex Alterations in Adulthood |
| title_full | Using Fractal Dimension Analysis with the Desikan–Killiany Atlas to Assess the Effects of Normal Aging on Subregional Cortex Alterations in Adulthood |
| title_fullStr | Using Fractal Dimension Analysis with the Desikan–Killiany Atlas to Assess the Effects of Normal Aging on Subregional Cortex Alterations in Adulthood |
| title_full_unstemmed | Using Fractal Dimension Analysis with the Desikan–Killiany Atlas to Assess the Effects of Normal Aging on Subregional Cortex Alterations in Adulthood |
| title_short | Using Fractal Dimension Analysis with the Desikan–Killiany Atlas to Assess the Effects of Normal Aging on Subregional Cortex Alterations in Adulthood |
| title_sort | using fractal dimension analysis with the desikan killiany atlas to assess the effects of normal aging on subregional cortex alterations in adulthood |
| topic | normal aging fractal dimension Desikan–Killiany Atlas prediagnosis |
| url | https://www.mdpi.com/2076-3425/11/1/107 |
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