Impact of Transplantation Timing on Renal Graft Survival Outcomes and Perioperative Complications
Nighttime organ transplantation aims to decrease cold ischemia duration, yet conflicting data exists on its impact on graft function and perioperative complications. This multicenter TRANSPLANT’AFUF study including 2,854 patients, transplanted between 1 January 2011, and 31 December 2022, investigat...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Transplant International |
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| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/ti.2024.12202/full |
| _version_ | 1827293161953689600 |
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| author | M. Uhl T. Waeckel E. Seizilles De Mazancourt F. Taha K. Kaulanjan A. Goujon A. Beretta J. Papet H. Dupuis A. Panis A. Peyrottes A. Lemaire C. Larose L. Bettler M. Pues C. Joncour G. Stempfer T. Ghestem P. De Sousa |
| author_facet | M. Uhl T. Waeckel E. Seizilles De Mazancourt F. Taha K. Kaulanjan A. Goujon A. Beretta J. Papet H. Dupuis A. Panis A. Peyrottes A. Lemaire C. Larose L. Bettler M. Pues C. Joncour G. Stempfer T. Ghestem P. De Sousa |
| author_sort | M. Uhl |
| collection | DOAJ |
| description | Nighttime organ transplantation aims to decrease cold ischemia duration, yet conflicting data exists on its impact on graft function and perioperative complications. This multicenter TRANSPLANT’AFUF study including 2,854 patients, transplanted between 1 January 2011, and 31 December 2022, investigated nighttime kidney transplantation’s impact (8:00 p.m.–8:00 a.m.) versus daytime (8:00 a.m.–8:00 p.m.) on surgical complications and graft survival. Overall, 2043 patients (71.6%) underwent daytime graft, while 811 (28.4%) underwent nighttime graft. No impact was observed of timing of graft surgery on graft survival with a median survival of 98 months and 132 months for daytime and nightime grafting, respectively (p = 0.1749). Moreover, no impact was observed on early surgical complications (Clavien I-II = 20.95% for DG and 20.10% for NG; Clavien III-IV-V = 15.42% for DG and 12.94% for NG; p = 0.0889) and late complications (>30 days) (Clavien I-II = 6.80% for DG and 5.67% for NG; Clavien III-IV-V = 12.78% for DG and 12.82% for NG; p = 0.2444). Noteworthy, we found a significant increase in Maastricht 3 donors’ rates in nighttime transplantation (5.53% DG vs. 21.45% NG; p < 0.0001). In conclusion, nighttime kidney transplantation did not impact early/late surgical complications nor graft survival. |
| first_indexed | 2024-04-24T13:19:32Z |
| format | Article |
| id | doaj.art-89a6074a329e4dbbaef84ad8d901d542 |
| institution | Directory Open Access Journal |
| issn | 1432-2277 |
| language | English |
| last_indexed | 2024-04-24T13:19:32Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Transplant International |
| spelling | doaj.art-89a6074a329e4dbbaef84ad8d901d5422024-04-04T16:24:19ZengFrontiers Media S.A.Transplant International1432-22772024-02-013710.3389/ti.2024.1220212202Impact of Transplantation Timing on Renal Graft Survival Outcomes and Perioperative ComplicationsM. Uhl0T. Waeckel1E. Seizilles De Mazancourt2F. Taha3K. Kaulanjan4A. Goujon5A. Beretta6J. Papet7H. Dupuis8A. Panis9A. Peyrottes10A. Lemaire11C. Larose12L. Bettler13M. Pues14C. Joncour15G. Stempfer16T. Ghestem17P. De Sousa18Urology, Centre Hospitalo-Universitaire Amiens Picardie, Amiens, FranceUrology, Centre Hospitalo-Universitaire Caen, Caen, FranceUrology, Centre Hospitalo-Universitaire Lyon, Lyon, FranceUrology, Centre Hospitalo-Universitaire Reims, Reims, FranceUrology, Centre Hospitalo-Universitaire Pointe A Pitre, Guadeloupe, Pointe à Pitre, FranceUrology, Centre Hospitalo-Universitaire Rennes, Rennes, FranceUrology, Centre Hospitalo-Universitaire Lyon, Lyon, FranceUrology, Centre Hospitalo-Universitaire Rouen, Rouen, FranceUrology, Centre Hospitalo-Universitaire Rouen, Rouen, FranceUrology, Centre Hospitalo-Universitaire Créteil, Paris, FranceUrology, Hôpital Européen Georges Pompidou, Paris, France0Urology, Hôpital Saint Louis, Paris, France1Urology, Centre Hospitalo-Universitaire Nancy, Nancy, France2Urology, Centre Hospitalo-Universitaire Dijon, Dijon, France3Urology, Centre Hospitalo-Universitaire Lille, Lille, FranceUrology, Centre Hospitalo-Universitaire Reims, Reims, FranceUrology, Centre Hospitalo-Universitaire Pointe A Pitre, Guadeloupe, Pointe à Pitre, FranceUrology, Centre Hospitalo-Universitaire Amiens Picardie, Amiens, FranceUrology, Centre Hospitalo-Universitaire Amiens Picardie, Amiens, FranceNighttime organ transplantation aims to decrease cold ischemia duration, yet conflicting data exists on its impact on graft function and perioperative complications. This multicenter TRANSPLANT’AFUF study including 2,854 patients, transplanted between 1 January 2011, and 31 December 2022, investigated nighttime kidney transplantation’s impact (8:00 p.m.–8:00 a.m.) versus daytime (8:00 a.m.–8:00 p.m.) on surgical complications and graft survival. Overall, 2043 patients (71.6%) underwent daytime graft, while 811 (28.4%) underwent nighttime graft. No impact was observed of timing of graft surgery on graft survival with a median survival of 98 months and 132 months for daytime and nightime grafting, respectively (p = 0.1749). Moreover, no impact was observed on early surgical complications (Clavien I-II = 20.95% for DG and 20.10% for NG; Clavien III-IV-V = 15.42% for DG and 12.94% for NG; p = 0.0889) and late complications (>30 days) (Clavien I-II = 6.80% for DG and 5.67% for NG; Clavien III-IV-V = 12.78% for DG and 12.82% for NG; p = 0.2444). Noteworthy, we found a significant increase in Maastricht 3 donors’ rates in nighttime transplantation (5.53% DG vs. 21.45% NG; p < 0.0001). In conclusion, nighttime kidney transplantation did not impact early/late surgical complications nor graft survival.https://www.frontierspartnerships.org/articles/10.3389/ti.2024.12202/fullrenal transplantationgraft survivalnighttimesurgerysurgical complication |
| spellingShingle | M. Uhl T. Waeckel E. Seizilles De Mazancourt F. Taha K. Kaulanjan A. Goujon A. Beretta J. Papet H. Dupuis A. Panis A. Peyrottes A. Lemaire C. Larose L. Bettler M. Pues C. Joncour G. Stempfer T. Ghestem P. De Sousa Impact of Transplantation Timing on Renal Graft Survival Outcomes and Perioperative Complications Transplant International renal transplantation graft survival nighttime surgery surgical complication |
| title | Impact of Transplantation Timing on Renal Graft Survival Outcomes and Perioperative Complications |
| title_full | Impact of Transplantation Timing on Renal Graft Survival Outcomes and Perioperative Complications |
| title_fullStr | Impact of Transplantation Timing on Renal Graft Survival Outcomes and Perioperative Complications |
| title_full_unstemmed | Impact of Transplantation Timing on Renal Graft Survival Outcomes and Perioperative Complications |
| title_short | Impact of Transplantation Timing on Renal Graft Survival Outcomes and Perioperative Complications |
| title_sort | impact of transplantation timing on renal graft survival outcomes and perioperative complications |
| topic | renal transplantation graft survival nighttime surgery surgical complication |
| url | https://www.frontierspartnerships.org/articles/10.3389/ti.2024.12202/full |
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