Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(<span style="font-variant: small-caps">l</span>-Lactide) Implant Coating Matrices—A Systematic Study
Local drug delivery has become indispensable in biomedical engineering with stents being ideal carrier platforms. While local drug release is superior to systemic administration in many fields, the incorporation of drugs into polymers may influence the physico-chemical properties of said matrix. Thi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/2/292 |
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| author | Daniela Arbeiter Thomas Reske Michael Teske Dalibor Bajer Volkmar Senz Klaus-Peter Schmitz Niels Grabow Stefan Oschatz |
| author_facet | Daniela Arbeiter Thomas Reske Michael Teske Dalibor Bajer Volkmar Senz Klaus-Peter Schmitz Niels Grabow Stefan Oschatz |
| author_sort | Daniela Arbeiter |
| collection | DOAJ |
| description | Local drug delivery has become indispensable in biomedical engineering with stents being ideal carrier platforms. While local drug release is superior to systemic administration in many fields, the incorporation of drugs into polymers may influence the physico-chemical properties of said matrix. This is of particular relevance as minimally invasive implantation is frequently accompanied by mechanical stresses on the implant and coating. Thus, drug incorporation into polymers may result in a susceptibility to potentially life-threatening implant failure. We investigated spray-coated poly-<span style="font-variant: small-caps;">l</span>-lactide (PLLA)/drug blends using thermal measurements (DSC) and tensile tests to determine the influence of selected drugs, namely sirolimus, paclitaxel, dexamethasone, and cyclosporine A, on the physico-chemical properties of the polymer. For all drugs and PLLA/drug ratios, an increase in tensile strength was observed. As for sirolimus and dexamethasone, PLLA/drug mixed phase systems were identified by shifted drug melting peaks at 200 °C and 240 °C, respectively, whereas paclitaxel and dexamethasone led to cold crystallization. Cyclosporine A did not affect matrix thermal properties. Altogether, our data provide a contribution towards an understanding of the complex interaction between PLLA and different drugs. Our results hold implications regarding the necessity of target-oriented thermal treatment to ensure the shelf life and performance of stent coatings. |
| first_indexed | 2024-03-09T04:24:02Z |
| format | Article |
| id | doaj.art-89a82984cbfc4a76adb35abaf10b232e |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T04:24:02Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-89a82984cbfc4a76adb35abaf10b232e2023-12-03T13:42:48ZengMDPI AGPolymers2073-43602021-01-0113229210.3390/polym13020292Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(<span style="font-variant: small-caps">l</span>-Lactide) Implant Coating Matrices—A Systematic StudyDaniela Arbeiter0Thomas Reske1Michael Teske2Dalibor Bajer3Volkmar Senz4Klaus-Peter Schmitz5Niels Grabow6Stefan Oschatz7Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Straße 4, 18119 Rostock, GermanyInstitute for Implant Technology and Biomaterials e.V., Friedrich-Barnewitz-Straße 4, 18119 Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Straße 4, 18119 Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Straße 4, 18119 Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Straße 4, 18119 Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Straße 4, 18119 Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Straße 4, 18119 Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Straße 4, 18119 Rostock, GermanyLocal drug delivery has become indispensable in biomedical engineering with stents being ideal carrier platforms. While local drug release is superior to systemic administration in many fields, the incorporation of drugs into polymers may influence the physico-chemical properties of said matrix. This is of particular relevance as minimally invasive implantation is frequently accompanied by mechanical stresses on the implant and coating. Thus, drug incorporation into polymers may result in a susceptibility to potentially life-threatening implant failure. We investigated spray-coated poly-<span style="font-variant: small-caps;">l</span>-lactide (PLLA)/drug blends using thermal measurements (DSC) and tensile tests to determine the influence of selected drugs, namely sirolimus, paclitaxel, dexamethasone, and cyclosporine A, on the physico-chemical properties of the polymer. For all drugs and PLLA/drug ratios, an increase in tensile strength was observed. As for sirolimus and dexamethasone, PLLA/drug mixed phase systems were identified by shifted drug melting peaks at 200 °C and 240 °C, respectively, whereas paclitaxel and dexamethasone led to cold crystallization. Cyclosporine A did not affect matrix thermal properties. Altogether, our data provide a contribution towards an understanding of the complex interaction between PLLA and different drugs. Our results hold implications regarding the necessity of target-oriented thermal treatment to ensure the shelf life and performance of stent coatings.https://www.mdpi.com/2073-4360/13/2/292drug-eluting stent (DES)poly-<span style="font-variant: small-caps">l</span>-lactidedrug delivery coatingsmechanical propertiesthermal propertiessurface morphology |
| spellingShingle | Daniela Arbeiter Thomas Reske Michael Teske Dalibor Bajer Volkmar Senz Klaus-Peter Schmitz Niels Grabow Stefan Oschatz Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(<span style="font-variant: small-caps">l</span>-Lactide) Implant Coating Matrices—A Systematic Study Polymers drug-eluting stent (DES) poly-<span style="font-variant: small-caps">l</span>-lactide drug delivery coatings mechanical properties thermal properties surface morphology |
| title | Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(<span style="font-variant: small-caps">l</span>-Lactide) Implant Coating Matrices—A Systematic Study |
| title_full | Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(<span style="font-variant: small-caps">l</span>-Lactide) Implant Coating Matrices—A Systematic Study |
| title_fullStr | Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(<span style="font-variant: small-caps">l</span>-Lactide) Implant Coating Matrices—A Systematic Study |
| title_full_unstemmed | Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(<span style="font-variant: small-caps">l</span>-Lactide) Implant Coating Matrices—A Systematic Study |
| title_short | Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(<span style="font-variant: small-caps">l</span>-Lactide) Implant Coating Matrices—A Systematic Study |
| title_sort | influence of drug incorporation on the physico chemical properties of poly span style font variant small caps l span lactide implant coating matrices a systematic study |
| topic | drug-eluting stent (DES) poly-<span style="font-variant: small-caps">l</span>-lactide drug delivery coatings mechanical properties thermal properties surface morphology |
| url | https://www.mdpi.com/2073-4360/13/2/292 |
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