The roles, molecular interactions, and therapeutic value of CDK16 in human cancers
Cyclin-dependent kinase 16 (CDK16) is an orphan “cyclin-dependent kinase” (CDK) involved in the cell cycle, vesicle trafficking, spindle orientation, skeletal myogenesis, neurite outgrowth, secretory cargo transport, spermatogenesis, glucose transportation, cell apoptosis, cell growth and proliferat...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
|
| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223007199 |
| _version_ | 1797801852714090496 |
|---|---|
| author | Xiao Wang Ruiqi Liu Shuang Li Wenjie Xia Haiwei Guo Weiping Yao Xiaodong Liang Yanwei Lu Haibo Zhang |
| author_facet | Xiao Wang Ruiqi Liu Shuang Li Wenjie Xia Haiwei Guo Weiping Yao Xiaodong Liang Yanwei Lu Haibo Zhang |
| author_sort | Xiao Wang |
| collection | DOAJ |
| description | Cyclin-dependent kinase 16 (CDK16) is an orphan “cyclin-dependent kinase” (CDK) involved in the cell cycle, vesicle trafficking, spindle orientation, skeletal myogenesis, neurite outgrowth, secretory cargo transport, spermatogenesis, glucose transportation, cell apoptosis, cell growth and proliferation, metastasis, and autophagy. Human CDK16 is located on chromosome Xp11.3 and is related to X-linked congenital diseases. CDK16 is commonly expressed in mammalian tissues and may act as an oncoprotein. It is a PCTAIRE kinase in which Cyclin Y or its homologue, Cyclin Y-like 1, regulates activity by binding to the N- and C- terminal regions of CDK16. CDK16 plays a vital role in various cancers, including lung cancer, prostate cancer, breast cancer, malignant melanoma, and hepatocellular carcinoma. CDK16 is a promising biomarker for cancer diagnosis and prognosis. In this review, we summarized and discussed the roles and mechanisms of CDK16 in human cancers. |
| first_indexed | 2024-03-13T04:56:50Z |
| format | Article |
| id | doaj.art-89a88ca2ec544c0698b04542a73cc1b2 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T04:56:50Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-89a88ca2ec544c0698b04542a73cc1b22023-06-18T05:00:44ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-08-01164114929The roles, molecular interactions, and therapeutic value of CDK16 in human cancersXiao Wang0Ruiqi Liu1Shuang Li2Wenjie Xia3Haiwei Guo4Weiping Yao5Xiaodong Liang6Yanwei Lu7Haibo Zhang8Cancer Center, Department of Medical Oncology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaCancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China; Graduate Department, Bengbu Medical College, Bengbu, Anhui, ChinaCancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaGeneral Surgery, Cancer Center, Department of Breast Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaOtolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People' s Hospital, Affiliated People's Hospital, Hangzhou Medical College, 310014, Hangzhou, Zhejiang, ChinaCancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China; Graduate Department, Bengbu Medical College, Bengbu, Anhui, ChinaCancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaCancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China; Corresponding authors.Cancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China; Corresponding authors.Cyclin-dependent kinase 16 (CDK16) is an orphan “cyclin-dependent kinase” (CDK) involved in the cell cycle, vesicle trafficking, spindle orientation, skeletal myogenesis, neurite outgrowth, secretory cargo transport, spermatogenesis, glucose transportation, cell apoptosis, cell growth and proliferation, metastasis, and autophagy. Human CDK16 is located on chromosome Xp11.3 and is related to X-linked congenital diseases. CDK16 is commonly expressed in mammalian tissues and may act as an oncoprotein. It is a PCTAIRE kinase in which Cyclin Y or its homologue, Cyclin Y-like 1, regulates activity by binding to the N- and C- terminal regions of CDK16. CDK16 plays a vital role in various cancers, including lung cancer, prostate cancer, breast cancer, malignant melanoma, and hepatocellular carcinoma. CDK16 is a promising biomarker for cancer diagnosis and prognosis. In this review, we summarized and discussed the roles and mechanisms of CDK16 in human cancers.http://www.sciencedirect.com/science/article/pii/S0753332223007199CDK16PCTAIRE1Cell cycleCancerPCTK1 |
| spellingShingle | Xiao Wang Ruiqi Liu Shuang Li Wenjie Xia Haiwei Guo Weiping Yao Xiaodong Liang Yanwei Lu Haibo Zhang The roles, molecular interactions, and therapeutic value of CDK16 in human cancers Biomedicine & Pharmacotherapy CDK16 PCTAIRE1 Cell cycle Cancer PCTK1 |
| title | The roles, molecular interactions, and therapeutic value of CDK16 in human cancers |
| title_full | The roles, molecular interactions, and therapeutic value of CDK16 in human cancers |
| title_fullStr | The roles, molecular interactions, and therapeutic value of CDK16 in human cancers |
| title_full_unstemmed | The roles, molecular interactions, and therapeutic value of CDK16 in human cancers |
| title_short | The roles, molecular interactions, and therapeutic value of CDK16 in human cancers |
| title_sort | roles molecular interactions and therapeutic value of cdk16 in human cancers |
| topic | CDK16 PCTAIRE1 Cell cycle Cancer PCTK1 |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223007199 |
| work_keys_str_mv | AT xiaowang therolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT ruiqiliu therolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT shuangli therolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT wenjiexia therolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT haiweiguo therolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT weipingyao therolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT xiaodongliang therolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT yanweilu therolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT haibozhang therolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT xiaowang rolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT ruiqiliu rolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT shuangli rolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT wenjiexia rolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT haiweiguo rolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT weipingyao rolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT xiaodongliang rolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT yanweilu rolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers AT haibozhang rolesmolecularinteractionsandtherapeuticvalueofcdk16inhumancancers |