Attenuation of Aging-Related Oxidative Stress Pathways by Phytonutrients: A Computational Systems Biology Analysis
Aging results from gradual accumulation of damage to the cellular functions caused by biochemical processes such as oxidative stress, inflammation-driven prolonged cellular senescence state, immune system malfunction, psychological stress, and epigenetic changes due to exposure to environmental toxi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/17/3762 |
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| author | V. A. Shiva Ayyadurai Prabhakar Deonikar |
| author_facet | V. A. Shiva Ayyadurai Prabhakar Deonikar |
| author_sort | V. A. Shiva Ayyadurai |
| collection | DOAJ |
| description | Aging results from gradual accumulation of damage to the cellular functions caused by biochemical processes such as oxidative stress, inflammation-driven prolonged cellular senescence state, immune system malfunction, psychological stress, and epigenetic changes due to exposure to environmental toxins. Plant-derived bioactive molecules have been shown to ameliorate the damage from oxidative stress. This research seeks to uncover the mechanisms of action of how phytochemicals from fruit/berry/vegetable (FBV) juice powder mitigate oxidative stress. The study uses a computational systems biology approach to (1) identify biomolecular pathways of oxidative stress; (2) identify phytochemicals from FBV juice powder and their specific action on oxidative stress mechanisms; and (3) quantitatively estimate the effects of FBV juice powder bioactive compounds on oxidative stress. The compounds in FBV affected two oxidative stress molecular pathways: (1) reactive oxygen species (ROS) production and (2) antioxidant enzyme production. Six bioactive compounds including cyanidin, delphinidin, ellagic acid, kaempherol, malvidin, and rutin in FBV significantly lowered production of ROS and increased the production of antioxidant enzymes such as catalase, heme oxygenase-1, superoxide dismutase, and glutathione peroxidase. FBV juice powder provides a combination of bioactive compounds that attenuate aging by affecting multiple pathways of oxidative stress. |
| first_indexed | 2024-03-10T23:15:32Z |
| format | Article |
| id | doaj.art-89aad9344deb4ed4a2f2ff43fbe75380 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T23:15:32Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-89aad9344deb4ed4a2f2ff43fbe753802023-11-19T08:38:47ZengMDPI AGNutrients2072-66432023-08-011517376210.3390/nu15173762Attenuation of Aging-Related Oxidative Stress Pathways by Phytonutrients: A Computational Systems Biology AnalysisV. A. Shiva Ayyadurai0Prabhakar Deonikar1Systems Biology Group, CytoSolve Research Division, CytoSolve, Cambridge, MA 02138, USASystems Biology Group, CytoSolve Research Division, CytoSolve, Cambridge, MA 02138, USAAging results from gradual accumulation of damage to the cellular functions caused by biochemical processes such as oxidative stress, inflammation-driven prolonged cellular senescence state, immune system malfunction, psychological stress, and epigenetic changes due to exposure to environmental toxins. Plant-derived bioactive molecules have been shown to ameliorate the damage from oxidative stress. This research seeks to uncover the mechanisms of action of how phytochemicals from fruit/berry/vegetable (FBV) juice powder mitigate oxidative stress. The study uses a computational systems biology approach to (1) identify biomolecular pathways of oxidative stress; (2) identify phytochemicals from FBV juice powder and their specific action on oxidative stress mechanisms; and (3) quantitatively estimate the effects of FBV juice powder bioactive compounds on oxidative stress. The compounds in FBV affected two oxidative stress molecular pathways: (1) reactive oxygen species (ROS) production and (2) antioxidant enzyme production. Six bioactive compounds including cyanidin, delphinidin, ellagic acid, kaempherol, malvidin, and rutin in FBV significantly lowered production of ROS and increased the production of antioxidant enzymes such as catalase, heme oxygenase-1, superoxide dismutase, and glutathione peroxidase. FBV juice powder provides a combination of bioactive compounds that attenuate aging by affecting multiple pathways of oxidative stress.https://www.mdpi.com/2072-6643/15/17/3762oxidative stressagingreactive oxygen speciesantioxidant enzymescomputational systems biologyCytoSolve |
| spellingShingle | V. A. Shiva Ayyadurai Prabhakar Deonikar Attenuation of Aging-Related Oxidative Stress Pathways by Phytonutrients: A Computational Systems Biology Analysis Nutrients oxidative stress aging reactive oxygen species antioxidant enzymes computational systems biology CytoSolve |
| title | Attenuation of Aging-Related Oxidative Stress Pathways by Phytonutrients: A Computational Systems Biology Analysis |
| title_full | Attenuation of Aging-Related Oxidative Stress Pathways by Phytonutrients: A Computational Systems Biology Analysis |
| title_fullStr | Attenuation of Aging-Related Oxidative Stress Pathways by Phytonutrients: A Computational Systems Biology Analysis |
| title_full_unstemmed | Attenuation of Aging-Related Oxidative Stress Pathways by Phytonutrients: A Computational Systems Biology Analysis |
| title_short | Attenuation of Aging-Related Oxidative Stress Pathways by Phytonutrients: A Computational Systems Biology Analysis |
| title_sort | attenuation of aging related oxidative stress pathways by phytonutrients a computational systems biology analysis |
| topic | oxidative stress aging reactive oxygen species antioxidant enzymes computational systems biology CytoSolve |
| url | https://www.mdpi.com/2072-6643/15/17/3762 |
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