Respiratory pathogens – Some altered antibiotic susceptibility after implementation of pneumococcus vaccine and antibiotic control strategies
Background/purpose: Antimicrobial resistance in Taiwan has been on the rise for two decades. The implementation of pneumococcal conjugate vaccination (PCV13) and enhanced antimicrobial control (2013–2015) by the government may have changed the antibiotic resistance. Methods: Four respiratory pathoge...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Journal of Microbiology, Immunology and Infection |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118219301513 |
| _version_ | 1818552759003119616 |
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| author | Yu-Chin Huang Chin-Fu Lin Pei-Ju Ting Tzu Han Tang Fang-Liang Huang Huei-Jen Chao Chun-Lung Wang Po-Yen Chen |
| author_facet | Yu-Chin Huang Chin-Fu Lin Pei-Ju Ting Tzu Han Tang Fang-Liang Huang Huei-Jen Chao Chun-Lung Wang Po-Yen Chen |
| author_sort | Yu-Chin Huang |
| collection | DOAJ |
| description | Background/purpose: Antimicrobial resistance in Taiwan has been on the rise for two decades. The implementation of pneumococcal conjugate vaccination (PCV13) and enhanced antimicrobial control (2013–2015) by the government may have changed the antibiotic resistance. Methods: Four respiratory pathogens (Streptococcus pneumoniae, Haemophilus influenzae, Streptococcus pyogenes, and Moraxella catarrhalis) isolated in a single medical center during 2008–2017 were studied. We defined three temporal stages: (a) the first era (2008–2012), prior to implementation of the national immunization program (PCV13 vaccination), (b) the second era (2013–2015), during which an enhanced antibiotic control strategy was implemented, and (c) the third era (2016–2017), after implementation. Antimicrobial drug sensitivities were collected from two other hospitals: one from east Taiwan, one from west-central Taiwan. Results: S. pneumoniae was frequently isolated during the first era. It declined progressively during the second era of PCV13 vaccination. S. pyogenes and M. catarrhalis were not frequently isolated. The drug susceptibility of S. pneumoniae to ceftriaxone and vancomycin remained high. The antimicrobial susceptibility of H. influenzae to amoxillin/clavulante declined over the three temporal stages, from 91.9%-79.5%–58.5% (all p < 0.05). Conclusion: Antimicrobial resistance of H. influenzae increased during the latter part of the study period. The PCV13 vaccination program reduced the invasive pneumococcal disease and reduced the stress on the emergent drug resistance. This enhanced antibiotic control strategy was effective in terms of nosocomial drug resistance but not for community-associated pathogens. |
| first_indexed | 2024-12-12T09:17:22Z |
| format | Article |
| id | doaj.art-89ab1a0526274d43b2d4666eb2fe0cc0 |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-12-12T09:17:22Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-89ab1a0526274d43b2d4666eb2fe0cc02022-12-22T00:29:21ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822020-10-01535682689Respiratory pathogens – Some altered antibiotic susceptibility after implementation of pneumococcus vaccine and antibiotic control strategiesYu-Chin Huang0Chin-Fu Lin1Pei-Ju Ting2Tzu Han Tang3Fang-Liang Huang4Huei-Jen Chao5Chun-Lung Wang6Po-Yen Chen7Division of Pediatrics Dalin Tzu Chi Hospital, Buddhish Tzu Chi Medical Foundation, Dalin Chiayi, TaiwanMicrobiology Section of the Medical Laboratory, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Pediatrics, Section of Infection, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Pediatrics, Section of Infection, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Pediatrics, Section of Infection, Taichung Veterans General Hospital, Taichung, Taiwan; Hung Kuang University Taichung, TaiwanUnit Department of Laboratory Medicine, Buddish Tzu Chi General Hospital, Hualien, TaiwanDivision of Pediatrics Dalin Tzu Chi Hospital, Buddhish Tzu Chi Medical Foundation, Dalin Chiayi, Taiwan; School of Medicine, Tzu Chi University, Hualien, TaiwanDepartment of Pediatrics, Section of Infection, Taichung Veterans General Hospital, Taichung, Taiwan; Corresponding author. Division of Infection, Department of Pediatrics, Taichung Veterans General Hospital, No. 1650, Taiwan Boulevard Sect. 4, Taichung City 40705, Taiwan. Fax: +886 4 23741359.Background/purpose: Antimicrobial resistance in Taiwan has been on the rise for two decades. The implementation of pneumococcal conjugate vaccination (PCV13) and enhanced antimicrobial control (2013–2015) by the government may have changed the antibiotic resistance. Methods: Four respiratory pathogens (Streptococcus pneumoniae, Haemophilus influenzae, Streptococcus pyogenes, and Moraxella catarrhalis) isolated in a single medical center during 2008–2017 were studied. We defined three temporal stages: (a) the first era (2008–2012), prior to implementation of the national immunization program (PCV13 vaccination), (b) the second era (2013–2015), during which an enhanced antibiotic control strategy was implemented, and (c) the third era (2016–2017), after implementation. Antimicrobial drug sensitivities were collected from two other hospitals: one from east Taiwan, one from west-central Taiwan. Results: S. pneumoniae was frequently isolated during the first era. It declined progressively during the second era of PCV13 vaccination. S. pyogenes and M. catarrhalis were not frequently isolated. The drug susceptibility of S. pneumoniae to ceftriaxone and vancomycin remained high. The antimicrobial susceptibility of H. influenzae to amoxillin/clavulante declined over the three temporal stages, from 91.9%-79.5%–58.5% (all p < 0.05). Conclusion: Antimicrobial resistance of H. influenzae increased during the latter part of the study period. The PCV13 vaccination program reduced the invasive pneumococcal disease and reduced the stress on the emergent drug resistance. This enhanced antibiotic control strategy was effective in terms of nosocomial drug resistance but not for community-associated pathogens.http://www.sciencedirect.com/science/article/pii/S1684118219301513Antibiotic control strategyAntimicrobial susceptibilityPneumococcus conjugate vaccine (PCV)Taiwan |
| spellingShingle | Yu-Chin Huang Chin-Fu Lin Pei-Ju Ting Tzu Han Tang Fang-Liang Huang Huei-Jen Chao Chun-Lung Wang Po-Yen Chen Respiratory pathogens – Some altered antibiotic susceptibility after implementation of pneumococcus vaccine and antibiotic control strategies Journal of Microbiology, Immunology and Infection Antibiotic control strategy Antimicrobial susceptibility Pneumococcus conjugate vaccine (PCV) Taiwan |
| title | Respiratory pathogens – Some altered antibiotic susceptibility after implementation of pneumococcus vaccine and antibiotic control strategies |
| title_full | Respiratory pathogens – Some altered antibiotic susceptibility after implementation of pneumococcus vaccine and antibiotic control strategies |
| title_fullStr | Respiratory pathogens – Some altered antibiotic susceptibility after implementation of pneumococcus vaccine and antibiotic control strategies |
| title_full_unstemmed | Respiratory pathogens – Some altered antibiotic susceptibility after implementation of pneumococcus vaccine and antibiotic control strategies |
| title_short | Respiratory pathogens – Some altered antibiotic susceptibility after implementation of pneumococcus vaccine and antibiotic control strategies |
| title_sort | respiratory pathogens some altered antibiotic susceptibility after implementation of pneumococcus vaccine and antibiotic control strategies |
| topic | Antibiotic control strategy Antimicrobial susceptibility Pneumococcus conjugate vaccine (PCV) Taiwan |
| url | http://www.sciencedirect.com/science/article/pii/S1684118219301513 |
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