A Pilot Randomized Controlled Trial of a Partial Meal Replacement Preconception Weight Loss Program for Women with Overweight and Obesity
About half of Australian women have a body mass index in the overweight or obese range at the start of pregnancy, with serious consequences including preterm birth, gestational hypertension and diabetes, caesarean section, stillbirth, and childhood obesity. Trials to limit weight gain during pregnan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/9/3200 |
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| author | Roslyn Muirhead Nathalie Kizirian Ravin Lal Kirsten Black Ann Prys-Davies Natasha Nassar Louise Baur Amanda Sainsbury Arianne Sweeting Tania Markovic Michael Skilton Jon Hyett Bradley de Vries William Tarnow-Mordi Jennie Brand-Miller Adrienne Gordon |
| author_facet | Roslyn Muirhead Nathalie Kizirian Ravin Lal Kirsten Black Ann Prys-Davies Natasha Nassar Louise Baur Amanda Sainsbury Arianne Sweeting Tania Markovic Michael Skilton Jon Hyett Bradley de Vries William Tarnow-Mordi Jennie Brand-Miller Adrienne Gordon |
| author_sort | Roslyn Muirhead |
| collection | DOAJ |
| description | About half of Australian women have a body mass index in the overweight or obese range at the start of pregnancy, with serious consequences including preterm birth, gestational hypertension and diabetes, caesarean section, stillbirth, and childhood obesity. Trials to limit weight gain during pregnancy have had limited success and reducing weight before pregnancy has greater potential to improve outcomes. The PreBabe Pilot study was a randomised controlled pilot trial to assess the feasibility, acceptability and potential weight loss achieved using a commercial online partial meal replacement program, (MR) vs. telephone-based conventional dietary advice, (DA) for pre-conception weight-loss over a 10-week period. Women 18–40 years of age with a BMI ≥ 25 kg/m<sup>2</sup> planning pregnancy within the next 6 to 12 months were included in the study. All participants had three clinic visits with a dietitian and one obstetric consultation. In total, 50 women were enrolled in the study between June 2018 and October 2019–26 in MR and 24 in DA. Study retention at the end of 10 week intervention 81% in the MR arm and 75% in the DA arm. In the-intention-to-treat analysis, women using meal replacements lost on average 5.4 ± 3.1% body weight compared to 2.3 ± 4.2% for women receiving conventional advice (<i>p</i> = 0.029). Over 80% of women in the MR arm rated the support received as excellent, compared to 39% in the DA arm (<i>p</i> < 0.001). Women assigned to the MR intervention were more likely to achieve pregnancy within 12 months of the 10 week intervention (57% (12 of 21) women assigned to MR intervention vs. 22% (4 of 18) assigned to the DA group (<i>p</i> = 0.049) became pregnant). The findings suggest that a weight loss intervention using meal replacements in the preconception period was acceptable and may result in greater weight loss than conventional dietary advice alone. |
| first_indexed | 2024-03-10T07:20:22Z |
| format | Article |
| id | doaj.art-89ace3257308448e83eb9632ea67b845 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T07:20:22Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-89ace3257308448e83eb9632ea67b8452023-11-22T14:38:58ZengMDPI AGNutrients2072-66432021-09-01139320010.3390/nu13093200A Pilot Randomized Controlled Trial of a Partial Meal Replacement Preconception Weight Loss Program for Women with Overweight and ObesityRoslyn Muirhead0Nathalie Kizirian1Ravin Lal2Kirsten Black3Ann Prys-Davies4Natasha Nassar5Louise Baur6Amanda Sainsbury7Arianne Sweeting8Tania Markovic9Michael Skilton10Jon Hyett11Bradley de Vries12William Tarnow-Mordi13Jennie Brand-Miller14Adrienne Gordon15Charles Perkins Centre, School of Life and Environmental Biosciences, University of Sydney, Sydney, NSW 2006, AustraliaCharles Perkins Centre, University of Sydney, Sydney, NSW 2006, AustraliaCharles Perkins Centre, University of Sydney, Sydney, NSW 2006, AustraliaSpeciality of Obstetrics, Gynaecology and Neonatology, Central Clinical School, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, AustraliaDepartment of Women and Babies, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW 2050, AustraliaCharles Perkins Centre, Childrens Hospital Westmead Clinical School, University of Sydney, Sydney, NSW 2006, AustraliaCharles Perkins Centre, Childrens Hospital Westmead Clinical School, University of Sydney, Sydney, NSW 2006, AustraliaSchool of Human Sciences, Faculty of Science, University of Western Australia, Crawley, WA 6009, AustraliaSydney Medical School, The University of Sydney, NSW 2006, AustraliaSydney Medical School, The University of Sydney, NSW 2006, AustraliaSydney Medical School, The University of Sydney, NSW 2006, AustraliaSpeciality of Obstetrics, Gynaecology and Neonatology, Central Clinical School, Faculty of Medicine and Health, Royal Prince Alfred Hospital Newborn Care, Sydney Local Health District, Sydney, NSW 2050, AustraliaSpeciality of Obstetrics, Gynaecology and Neonatology, Central Clinical School, Faculty of Medicine and Health, Royal Prince Alfred Hospital Newborn Care, Sydney Local Health District, Sydney, NSW 2050, AustraliaClinical Trial Centre, Department of Neonatology, University of Sydney, Westmead Hospital, Sydney, NSW 2006, AustraliaCharles Perkins Centre, School of Life and Environmental Biosciences, University of Sydney, Sydney, NSW 2006, AustraliaSpeciality of Obstetrics, Gynaecology and Neonatology, Central Clinical School, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, AustraliaAbout half of Australian women have a body mass index in the overweight or obese range at the start of pregnancy, with serious consequences including preterm birth, gestational hypertension and diabetes, caesarean section, stillbirth, and childhood obesity. Trials to limit weight gain during pregnancy have had limited success and reducing weight before pregnancy has greater potential to improve outcomes. The PreBabe Pilot study was a randomised controlled pilot trial to assess the feasibility, acceptability and potential weight loss achieved using a commercial online partial meal replacement program, (MR) vs. telephone-based conventional dietary advice, (DA) for pre-conception weight-loss over a 10-week period. Women 18–40 years of age with a BMI ≥ 25 kg/m<sup>2</sup> planning pregnancy within the next 6 to 12 months were included in the study. All participants had three clinic visits with a dietitian and one obstetric consultation. In total, 50 women were enrolled in the study between June 2018 and October 2019–26 in MR and 24 in DA. Study retention at the end of 10 week intervention 81% in the MR arm and 75% in the DA arm. In the-intention-to-treat analysis, women using meal replacements lost on average 5.4 ± 3.1% body weight compared to 2.3 ± 4.2% for women receiving conventional advice (<i>p</i> = 0.029). Over 80% of women in the MR arm rated the support received as excellent, compared to 39% in the DA arm (<i>p</i> < 0.001). Women assigned to the MR intervention were more likely to achieve pregnancy within 12 months of the 10 week intervention (57% (12 of 21) women assigned to MR intervention vs. 22% (4 of 18) assigned to the DA group (<i>p</i> = 0.049) became pregnant). The findings suggest that a weight loss intervention using meal replacements in the preconception period was acceptable and may result in greater weight loss than conventional dietary advice alone.https://www.mdpi.com/2072-6643/13/9/3200preconceptionobesitymeal replacementweight lossclinical trial |
| spellingShingle | Roslyn Muirhead Nathalie Kizirian Ravin Lal Kirsten Black Ann Prys-Davies Natasha Nassar Louise Baur Amanda Sainsbury Arianne Sweeting Tania Markovic Michael Skilton Jon Hyett Bradley de Vries William Tarnow-Mordi Jennie Brand-Miller Adrienne Gordon A Pilot Randomized Controlled Trial of a Partial Meal Replacement Preconception Weight Loss Program for Women with Overweight and Obesity Nutrients preconception obesity meal replacement weight loss clinical trial |
| title | A Pilot Randomized Controlled Trial of a Partial Meal Replacement Preconception Weight Loss Program for Women with Overweight and Obesity |
| title_full | A Pilot Randomized Controlled Trial of a Partial Meal Replacement Preconception Weight Loss Program for Women with Overweight and Obesity |
| title_fullStr | A Pilot Randomized Controlled Trial of a Partial Meal Replacement Preconception Weight Loss Program for Women with Overweight and Obesity |
| title_full_unstemmed | A Pilot Randomized Controlled Trial of a Partial Meal Replacement Preconception Weight Loss Program for Women with Overweight and Obesity |
| title_short | A Pilot Randomized Controlled Trial of a Partial Meal Replacement Preconception Weight Loss Program for Women with Overweight and Obesity |
| title_sort | pilot randomized controlled trial of a partial meal replacement preconception weight loss program for women with overweight and obesity |
| topic | preconception obesity meal replacement weight loss clinical trial |
| url | https://www.mdpi.com/2072-6643/13/9/3200 |
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