Adrenergic Stimulation–Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries
The present study investigated whether histamine was taken up by perivascular adrenergic nerves and released by periarterial nerve stimulation (PNS) to induce vascular responses. In rat mesenteric vascular beds treated with capsaicin to eliminate calcitonin gene–related peptide (CGRP)ergic vasodilat...
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| Format: | Article |
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Elsevier
2012-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319305481 |
| _version_ | 1828390677254242304 |
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| author | Yuto Haruki Shingo Takatori Sayo Hattori Yoshito Zamami Toshihiro Koyama Panot Tangsucharit Hiromu Kawasaki |
| author_facet | Yuto Haruki Shingo Takatori Sayo Hattori Yoshito Zamami Toshihiro Koyama Panot Tangsucharit Hiromu Kawasaki |
| author_sort | Yuto Haruki |
| collection | DOAJ |
| description | The present study investigated whether histamine was taken up by perivascular adrenergic nerves and released by periarterial nerve stimulation (PNS) to induce vascular responses. In rat mesenteric vascular beds treated with capsaicin to eliminate calcitonin gene–related peptide (CGRP)ergic vasodilation and with active tone, PNS (1 – 4 Hz) induced only adrenergic nerve–mediated vasoconstriction. Histamine treatment for 20 min induced PNS-induced vasoconstriction followed by vasodilation without affecting CGRP-induced vasodilation. Chlorpheniramine, guanethidine, combination of histamine and desipramine, and endothelium-removal abolished PNS-induced vasodilation in histamine-treated preparations. These results suggest that histamine taken up by and released from adrenergic nerves by PNS causes endothelium-dependent vasodilation in rat mesenteric arteries. Keywords:: histamine, perivascular adrenergic nerve, rat mesenteric artery |
| first_indexed | 2024-12-10T06:50:07Z |
| format | Article |
| id | doaj.art-89ad3720fbd54796bff2c8c8fabea39a |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-10T06:50:07Z |
| publishDate | 2012-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-89ad3720fbd54796bff2c8c8fabea39a2022-12-22T01:58:34ZengElsevierJournal of Pharmacological Sciences1347-86132012-01-011184537542Adrenergic Stimulation–Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance ArteriesYuto Haruki0Shingo Takatori1Sayo Hattori2Yoshito Zamami3Toshihiro Koyama4Panot Tangsucharit5Hiromu Kawasaki6Department of Clinical Pharmaceutical Science, 1-1-1 Tsushima-naka, Okayama 700-8530, JapanDepartment of Clinical Pharmaceutical Science, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan; Corresponding author. s.takatori@pharm.okayama-u.ac.jpDepartment of Clinical Pharmaceutical Science, 1-1-1 Tsushima-naka, Okayama 700-8530, JapanDepartment of Molecular Design for Medicine, 1-1-1 Tsushima-naka, Okayama 700-8530, JapanDepartment of Pharmaceutical Care and Health Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, JapanDepartment of Clinical Pharmaceutical Science, 1-1-1 Tsushima-naka, Okayama 700-8530, JapanDepartment of Clinical Pharmaceutical Science, 1-1-1 Tsushima-naka, Okayama 700-8530, JapanThe present study investigated whether histamine was taken up by perivascular adrenergic nerves and released by periarterial nerve stimulation (PNS) to induce vascular responses. In rat mesenteric vascular beds treated with capsaicin to eliminate calcitonin gene–related peptide (CGRP)ergic vasodilation and with active tone, PNS (1 – 4 Hz) induced only adrenergic nerve–mediated vasoconstriction. Histamine treatment for 20 min induced PNS-induced vasoconstriction followed by vasodilation without affecting CGRP-induced vasodilation. Chlorpheniramine, guanethidine, combination of histamine and desipramine, and endothelium-removal abolished PNS-induced vasodilation in histamine-treated preparations. These results suggest that histamine taken up by and released from adrenergic nerves by PNS causes endothelium-dependent vasodilation in rat mesenteric arteries. Keywords:: histamine, perivascular adrenergic nerve, rat mesenteric arteryhttp://www.sciencedirect.com/science/article/pii/S1347861319305481 |
| spellingShingle | Yuto Haruki Shingo Takatori Sayo Hattori Yoshito Zamami Toshihiro Koyama Panot Tangsucharit Hiromu Kawasaki Adrenergic Stimulation–Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries Journal of Pharmacological Sciences |
| title | Adrenergic Stimulation–Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries |
| title_full | Adrenergic Stimulation–Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries |
| title_fullStr | Adrenergic Stimulation–Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries |
| title_full_unstemmed | Adrenergic Stimulation–Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries |
| title_short | Adrenergic Stimulation–Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries |
| title_sort | adrenergic stimulation released histamine taken up in adrenergic nerves induces endothelium dependent vasodilation in rat mesenteric resistance arteries |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319305481 |
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