Decorative Multi-Walled Carbon Nanotubes by ZnO: Synthesis, Characterization, and Potent Anti-Toxoplasmosis Activity
Toxoplasmosis may become a fatal disease in immunodeficient, diabetic patients, pregnant women, and infants. Hence, the diligent search for new effective treatment is among the major concerns worldwide. The well-dispersed multi-walled carbon nanotubes lined with ZnO (ZnO-MWCNT), graphene oxide (GO-N...
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MDPI AG
2022-07-01
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| Series: | Metals |
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| Online Access: | https://www.mdpi.com/2075-4701/12/8/1246 |
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| author | Jehan Y. Al-Humaidi Mohamed Hagar Basant A. Bakr Bassma H. Elwakil Esraa Abdelhamid Moneer Mostafa El-Khatib |
| author_facet | Jehan Y. Al-Humaidi Mohamed Hagar Basant A. Bakr Bassma H. Elwakil Esraa Abdelhamid Moneer Mostafa El-Khatib |
| author_sort | Jehan Y. Al-Humaidi |
| collection | DOAJ |
| description | Toxoplasmosis may become a fatal disease in immunodeficient, diabetic patients, pregnant women, and infants. Hence, the diligent search for new effective treatment is among the major concerns worldwide. The well-dispersed multi-walled carbon nanotubes lined with ZnO (ZnO-MWCNT), graphene oxide (GO-NPs), and zinc oxide (ZnO-NPs) were successfully synthesized through rapid and facile hydrothermal arc discharge technique (HTADT). The antiparasitic effects of ZnO-NPs, GO-NPs, and ZnO-MWCNT were investigated in mice infected with <i>Toxoplasma gondii</i>. The percent of tachyzoites reduction were detected. The observed results demonstrated that ZnO-MWCNT revealed a significant reduction in the parasite count reached 61% in brain tissues, followed by liver (52%), then spleen (45%). The assessments of antiparasitic, inflammatory, and anti-inflammatory cytokines confirmed the superior activity of ZnO-MWCNT as antiparasitic agent, which paves the way for the employment of ZnO-MWCNT as a treatment for the acute RH strain of <i>T. gondii</i> infection in vivo. |
| first_indexed | 2024-03-09T12:57:02Z |
| format | Article |
| id | doaj.art-89ae7e277d3b47939b6ca455d87fb3f9 |
| institution | Directory Open Access Journal |
| issn | 2075-4701 |
| language | English |
| last_indexed | 2024-03-09T12:57:02Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metals |
| spelling | doaj.art-89ae7e277d3b47939b6ca455d87fb3f92023-11-30T21:58:39ZengMDPI AGMetals2075-47012022-07-01128124610.3390/met12081246Decorative Multi-Walled Carbon Nanotubes by ZnO: Synthesis, Characterization, and Potent Anti-Toxoplasmosis ActivityJehan Y. Al-Humaidi0Mohamed Hagar1Basant A. Bakr2Bassma H. Elwakil3Esraa Abdelhamid Moneer4Mostafa El-Khatib5Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi ArabiaDepartment of Chemistry, Faculty of Science, Alexandria University, Alexandria 21321, EgyptDepartment of Zoology, Faculty of Science, Alexandria University, Alexandria 21321, EgyptDepartment of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria 21526, EgyptDepartment of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria 21526, EgyptBasic Sciences Department, Faculty of Engineering, Pharos University in Alexandria, Alexandria 21526, EgyptToxoplasmosis may become a fatal disease in immunodeficient, diabetic patients, pregnant women, and infants. Hence, the diligent search for new effective treatment is among the major concerns worldwide. The well-dispersed multi-walled carbon nanotubes lined with ZnO (ZnO-MWCNT), graphene oxide (GO-NPs), and zinc oxide (ZnO-NPs) were successfully synthesized through rapid and facile hydrothermal arc discharge technique (HTADT). The antiparasitic effects of ZnO-NPs, GO-NPs, and ZnO-MWCNT were investigated in mice infected with <i>Toxoplasma gondii</i>. The percent of tachyzoites reduction were detected. The observed results demonstrated that ZnO-MWCNT revealed a significant reduction in the parasite count reached 61% in brain tissues, followed by liver (52%), then spleen (45%). The assessments of antiparasitic, inflammatory, and anti-inflammatory cytokines confirmed the superior activity of ZnO-MWCNT as antiparasitic agent, which paves the way for the employment of ZnO-MWCNT as a treatment for the acute RH strain of <i>T. gondii</i> infection in vivo.https://www.mdpi.com/2075-4701/12/8/1246arc dischargenanostructuresZnO-MWCNTantiparasitic<i>Toxoplasma gondii</i>in vivo study |
| spellingShingle | Jehan Y. Al-Humaidi Mohamed Hagar Basant A. Bakr Bassma H. Elwakil Esraa Abdelhamid Moneer Mostafa El-Khatib Decorative Multi-Walled Carbon Nanotubes by ZnO: Synthesis, Characterization, and Potent Anti-Toxoplasmosis Activity Metals arc discharge nanostructures ZnO-MWCNT antiparasitic <i>Toxoplasma gondii</i> in vivo study |
| title | Decorative Multi-Walled Carbon Nanotubes by ZnO: Synthesis, Characterization, and Potent Anti-Toxoplasmosis Activity |
| title_full | Decorative Multi-Walled Carbon Nanotubes by ZnO: Synthesis, Characterization, and Potent Anti-Toxoplasmosis Activity |
| title_fullStr | Decorative Multi-Walled Carbon Nanotubes by ZnO: Synthesis, Characterization, and Potent Anti-Toxoplasmosis Activity |
| title_full_unstemmed | Decorative Multi-Walled Carbon Nanotubes by ZnO: Synthesis, Characterization, and Potent Anti-Toxoplasmosis Activity |
| title_short | Decorative Multi-Walled Carbon Nanotubes by ZnO: Synthesis, Characterization, and Potent Anti-Toxoplasmosis Activity |
| title_sort | decorative multi walled carbon nanotubes by zno synthesis characterization and potent anti toxoplasmosis activity |
| topic | arc discharge nanostructures ZnO-MWCNT antiparasitic <i>Toxoplasma gondii</i> in vivo study |
| url | https://www.mdpi.com/2075-4701/12/8/1246 |
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