Metformin and Autoimmunity: A “New Deal” of an Old Drug

Metformin and Autoimmunity: A “New Deal” of an Old Drug

Metformin (dimethyl biguanide) is a synthetic derivative of guanidine, isolated from the extracts of Galega officinalis, a plant with a prominent antidiabetic effect. Since its discovery more than 50 years ago, metformin represents a worldwide milestone in treatment of patients with type 2 diabetes...

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Bibliographic Details
Main Authors: Francesco Ursini, Emilio Russo, Gianluca Pellino, Salvatore D’Angelo, Agostino Chiaravalloti, Giovambattista De Sarro, Roberto Manfredini, Roberto De Giorgio
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
metformin
autoimmunity
autoimmune diseases
T cell
B cell
macrophage
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01236/full

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