A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanisms
This clinical case presents a patient with NSCLC who experienced on-target resistant mutations and tumor cell transformation from adenocarcinoma to large cell neuroendocrine and small cell carcinoma. Our patient was successfully treated with a combination of targeted therapy, immunotherapy and chemo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Current Problems in Cancer: Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666621924000073 |
| _version_ | 1797256286715248640 |
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| author | Joel Rivera-Concepcion Ying-Chun Lo Dipesh Uprety Alex A. Adjei Vinicius Ernani Konstantinos Leventakos |
| author_facet | Joel Rivera-Concepcion Ying-Chun Lo Dipesh Uprety Alex A. Adjei Vinicius Ernani Konstantinos Leventakos |
| author_sort | Joel Rivera-Concepcion |
| collection | DOAJ |
| description | This clinical case presents a patient with NSCLC who experienced on-target resistant mutations and tumor cell transformation from adenocarcinoma to large cell neuroendocrine and small cell carcinoma. Our patient was successfully treated with a combination of targeted therapy, immunotherapy and chemotherapy based on genetic and histologic changes that occurred in a period of five years. |
| first_indexed | 2024-03-08T00:48:06Z |
| format | Article |
| id | doaj.art-89b01e3fc5fe4031b3866f1dd44b3b45 |
| institution | Directory Open Access Journal |
| issn | 2666-6219 |
| language | English |
| last_indexed | 2024-04-24T22:19:20Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Problems in Cancer: Case Reports |
| spelling | doaj.art-89b01e3fc5fe4031b3866f1dd44b3b452024-03-20T06:11:29ZengElsevierCurrent Problems in Cancer: Case Reports2666-62192024-03-0113100284A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanismsJoel Rivera-Concepcion0Ying-Chun Lo1Dipesh Uprety2Alex A. Adjei3Vinicius Ernani4Konstantinos Leventakos5Department of Medical Oncology, Duke Cancer Institute, 20 Duke Medicine Circle, Durham, NC 27710, United StatesDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United StatesBarbara Ann Karmanos Cancer Institute, Wayne State University, Department of Medical Oncology, 4100 John R Street, Detroit, MI 48201, United StatesCleveland Clinic, Taussig Cancer Institute, 10201 Carnegie Avenue, Cleveland, OH 44106, United StatesDivision of Medical Oncology, Mayo Clinic, 13400 E. Shea Blvd., Scottsdale, AZ 85259, United StatesDivision of Medical Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States; Corresponding author.This clinical case presents a patient with NSCLC who experienced on-target resistant mutations and tumor cell transformation from adenocarcinoma to large cell neuroendocrine and small cell carcinoma. Our patient was successfully treated with a combination of targeted therapy, immunotherapy and chemotherapy based on genetic and histologic changes that occurred in a period of five years.http://www.sciencedirect.com/science/article/pii/S2666621924000073NSCLCEGFR mutationHistologic transformationAcquired resistanceNeuroendocrine cancer |
| spellingShingle | Joel Rivera-Concepcion Ying-Chun Lo Dipesh Uprety Alex A. Adjei Vinicius Ernani Konstantinos Leventakos A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanisms Current Problems in Cancer: Case Reports NSCLC EGFR mutation Histologic transformation Acquired resistance Neuroendocrine cancer |
| title | A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanisms |
| title_full | A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanisms |
| title_fullStr | A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanisms |
| title_full_unstemmed | A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanisms |
| title_short | A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanisms |
| title_sort | challenging case of stage iv egfr mutant lung cancer with histologic transformation and multiple resistance mechanisms |
| topic | NSCLC EGFR mutation Histologic transformation Acquired resistance Neuroendocrine cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2666621924000073 |
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