The effect of prophylactic chemotherapy on treatment outcome of postmolar gestational trophoblastic neoplasia
Abstract Objective To evaluate whether prophylactic chemotherapy (P-chem) increased the drug resistance rate of postmolar GTN and whether the first-line chemotherapy should be different from P-chem. Methods Postmolar GTN received P-Chem was defined as P-Chem group. Postmolar GTN without P-chem was r...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-022-02134-w |
| _version_ | 1797958489845268480 |
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| author | Yuanyuan Liu Yaqiong Ye Xiaodong Cheng Weiguo Lu Xing Xie Xinyu Wang Xiao Li |
| author_facet | Yuanyuan Liu Yaqiong Ye Xiaodong Cheng Weiguo Lu Xing Xie Xinyu Wang Xiao Li |
| author_sort | Yuanyuan Liu |
| collection | DOAJ |
| description | Abstract Objective To evaluate whether prophylactic chemotherapy (P-chem) increased the drug resistance rate of postmolar GTN and whether the first-line chemotherapy should be different from P-chem. Methods Postmolar GTN received P-Chem was defined as P-Chem group. Postmolar GTN without P-chem was randomly selected as control group according to the ratio of 1:3 (P-chem:control) and matched by age for low risk and high risk GTN separately. Results Totally 455 low-risk and 32 high-risk postmolar GTN patients were included. WHO risk score, chemotherapy cycles to achieve hCG normalization and resistant rate were similar between P-chem (27 cases) and control (81 cases) group. Among low-risk GTN patients, interval from hydatidiform mole to GTN was significantly longer in P-chem group than control (44 vs 69 days, P = 0.001). Total chemotherapy cycles and resistant rate were similar between low-risk GTN treated with same agent as P-chem (group A) and alternative agent (group B). But group A needed more chemotherapy cycles to achieve hCG normalization than group B. Conclusions P-chem delayed the time to GTN diagnosis, but didn’t increase risk score or lead to drug resistance of postmolar GTN. Alternative agent different from P-chem had the potential of enhancing chemotherapy response in low- risk postmolar GTN. |
| first_indexed | 2024-04-11T00:20:51Z |
| format | Article |
| id | doaj.art-89b22d29347d4c10aeb3f5c628bfb9b0 |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-04-11T00:20:51Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-89b22d29347d4c10aeb3f5c628bfb9b02023-01-08T12:19:41ZengBMCBMC Women's Health1472-68742023-01-012311810.1186/s12905-022-02134-wThe effect of prophylactic chemotherapy on treatment outcome of postmolar gestational trophoblastic neoplasiaYuanyuan Liu0Yaqiong Ye1Xiaodong Cheng2Weiguo Lu3Xing Xie4Xinyu Wang5Xiao Li6Department of Gynecologic Oncology, Women’s Hospital, Zhejiang University School of MedicineZhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecologic Oncology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecologic Oncology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecologic Oncology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecologic Oncology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Gynecologic Oncology, Women’s Hospital, Zhejiang University School of MedicineAbstract Objective To evaluate whether prophylactic chemotherapy (P-chem) increased the drug resistance rate of postmolar GTN and whether the first-line chemotherapy should be different from P-chem. Methods Postmolar GTN received P-Chem was defined as P-Chem group. Postmolar GTN without P-chem was randomly selected as control group according to the ratio of 1:3 (P-chem:control) and matched by age for low risk and high risk GTN separately. Results Totally 455 low-risk and 32 high-risk postmolar GTN patients were included. WHO risk score, chemotherapy cycles to achieve hCG normalization and resistant rate were similar between P-chem (27 cases) and control (81 cases) group. Among low-risk GTN patients, interval from hydatidiform mole to GTN was significantly longer in P-chem group than control (44 vs 69 days, P = 0.001). Total chemotherapy cycles and resistant rate were similar between low-risk GTN treated with same agent as P-chem (group A) and alternative agent (group B). But group A needed more chemotherapy cycles to achieve hCG normalization than group B. Conclusions P-chem delayed the time to GTN diagnosis, but didn’t increase risk score or lead to drug resistance of postmolar GTN. Alternative agent different from P-chem had the potential of enhancing chemotherapy response in low- risk postmolar GTN.https://doi.org/10.1186/s12905-022-02134-wHydatidiform moleProphylactic chemotherapyGestational trophoblastic neoplasiaChemotherapy resistance |
| spellingShingle | Yuanyuan Liu Yaqiong Ye Xiaodong Cheng Weiguo Lu Xing Xie Xinyu Wang Xiao Li The effect of prophylactic chemotherapy on treatment outcome of postmolar gestational trophoblastic neoplasia BMC Women's Health Hydatidiform mole Prophylactic chemotherapy Gestational trophoblastic neoplasia Chemotherapy resistance |
| title | The effect of prophylactic chemotherapy on treatment outcome of postmolar gestational trophoblastic neoplasia |
| title_full | The effect of prophylactic chemotherapy on treatment outcome of postmolar gestational trophoblastic neoplasia |
| title_fullStr | The effect of prophylactic chemotherapy on treatment outcome of postmolar gestational trophoblastic neoplasia |
| title_full_unstemmed | The effect of prophylactic chemotherapy on treatment outcome of postmolar gestational trophoblastic neoplasia |
| title_short | The effect of prophylactic chemotherapy on treatment outcome of postmolar gestational trophoblastic neoplasia |
| title_sort | effect of prophylactic chemotherapy on treatment outcome of postmolar gestational trophoblastic neoplasia |
| topic | Hydatidiform mole Prophylactic chemotherapy Gestational trophoblastic neoplasia Chemotherapy resistance |
| url | https://doi.org/10.1186/s12905-022-02134-w |
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