Zinc complex compound with N-alkenylimidazoles: biological activity and application in medicine (review)
Development of pharmaceuticals on the basis of zinc complexes containing imidazoles as ligand systems appears promising. High activity and a wide range of pharmacological effects of such compounds result from zinc biological role as n essential trace element, and zinc bioavailability with imidazol cy...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
2022-12-01
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| Series: | Сеченовский вестник |
| Subjects: | |
| Online Access: | https://www.sechenovmedj.com/jour/article/view/666 |
| _version_ | 1797873658868269056 |
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| author | S. A. Shakhmardanova P. A. Galenko-Yaroshevsky |
| author_facet | S. A. Shakhmardanova P. A. Galenko-Yaroshevsky |
| author_sort | S. A. Shakhmardanova |
| collection | DOAJ |
| description | Development of pharmaceuticals on the basis of zinc complexes containing imidazoles as ligand systems appears promising. High activity and a wide range of pharmacological effects of such compounds result from zinc biological role as n essential trace element, and zinc bioavailability with imidazol cycles in the complex structure. The article reviews the molecular mechanisms of zinc homeostasis. The article analyzes the literary data and the data of our studies and discusses the application of zinc complexes with N-alkenylimidazole in medicine on the example of Acyzol. |
| first_indexed | 2024-04-10T01:18:39Z |
| format | Article |
| id | doaj.art-89b23847b65b4ce3871b6118dd4514b4 |
| institution | Directory Open Access Journal |
| issn | 2218-7332 2658-3348 |
| language | Russian |
| last_indexed | 2024-04-10T01:18:39Z |
| publishDate | 2022-12-01 |
| publisher | Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University) |
| record_format | Article |
| series | Сеченовский вестник |
| spelling | doaj.art-89b23847b65b4ce3871b6118dd4514b42023-03-13T09:51:35ZrusFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Сеченовский вестник2218-73322658-33482022-12-01038490360Zinc complex compound with N-alkenylimidazoles: biological activity and application in medicine (review)S. A. Shakhmardanova0P. A. Galenko-Yaroshevsky1I.M. Sechenov First Moscow State Medical UniversityKuban State Medical UniversityDevelopment of pharmaceuticals on the basis of zinc complexes containing imidazoles as ligand systems appears promising. High activity and a wide range of pharmacological effects of such compounds result from zinc biological role as n essential trace element, and zinc bioavailability with imidazol cycles in the complex structure. The article reviews the molecular mechanisms of zinc homeostasis. The article analyzes the literary data and the data of our studies and discusses the application of zinc complexes with N-alkenylimidazole in medicine on the example of Acyzol.https://www.sechenovmedj.com/jour/article/view/666zincmetal complex compoundsn-alkenylimidazolesacyzol |
| spellingShingle | S. A. Shakhmardanova P. A. Galenko-Yaroshevsky Zinc complex compound with N-alkenylimidazoles: biological activity and application in medicine (review) Сеченовский вестник zinc metal complex compounds n-alkenylimidazoles acyzol |
| title | Zinc complex compound with N-alkenylimidazoles: biological activity and application in medicine (review) |
| title_full | Zinc complex compound with N-alkenylimidazoles: biological activity and application in medicine (review) |
| title_fullStr | Zinc complex compound with N-alkenylimidazoles: biological activity and application in medicine (review) |
| title_full_unstemmed | Zinc complex compound with N-alkenylimidazoles: biological activity and application in medicine (review) |
| title_short | Zinc complex compound with N-alkenylimidazoles: biological activity and application in medicine (review) |
| title_sort | zinc complex compound with n alkenylimidazoles biological activity and application in medicine review |
| topic | zinc metal complex compounds n-alkenylimidazoles acyzol |
| url | https://www.sechenovmedj.com/jour/article/view/666 |
| work_keys_str_mv | AT sashakhmardanova zinccomplexcompoundwithnalkenylimidazolesbiologicalactivityandapplicationinmedicinereview AT pagalenkoyaroshevsky zinccomplexcompoundwithnalkenylimidazolesbiologicalactivityandapplicationinmedicinereview |