A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration
Abstract Tactile sensation and vision are often both utilized for the exploration of objects that are within reach though it is not known whether or how these two distinct sensory systems combine such information. Here in mice, we used a combination of stereo photogrammetry for 3D reconstruction of...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-47459-2 |
| _version_ | 1827284230678249472 |
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| author | Simon Weiler Vahid Rahmati Marcel Isstas Johann Wutke Andreas Walter Stark Christian Franke Jürgen Graf Christian Geis Otto W. Witte Mark Hübener Jürgen Bolz Troy W. Margrie Knut Holthoff Manuel Teichert |
| author_facet | Simon Weiler Vahid Rahmati Marcel Isstas Johann Wutke Andreas Walter Stark Christian Franke Jürgen Graf Christian Geis Otto W. Witte Mark Hübener Jürgen Bolz Troy W. Margrie Knut Holthoff Manuel Teichert |
| author_sort | Simon Weiler |
| collection | DOAJ |
| description | Abstract Tactile sensation and vision are often both utilized for the exploration of objects that are within reach though it is not known whether or how these two distinct sensory systems combine such information. Here in mice, we used a combination of stereo photogrammetry for 3D reconstruction of the whisker array, brain-wide anatomical tracing and functional connectivity analysis to explore the possibility of tacto-visual convergence in sensory space and within the circuitry of the primary visual cortex (VISp). Strikingly, we find that stimulation of the contralateral whisker array suppresses visually evoked activity in a tacto-visual sub-region of VISp whose visual space representation closely overlaps with the whisker search space. This suppression is mediated by local fast-spiking interneurons that receive a direct cortico-cortical input predominantly from layer 6 neurons located in the posterior primary somatosensory barrel cortex (SSp-bfd). These data demonstrate functional convergence within and between two primary sensory cortical areas for multisensory object detection and recognition. |
| first_indexed | 2024-04-24T09:52:21Z |
| format | Article |
| id | doaj.art-89b253e6788f4c7bad847a600e743e75 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-24T09:52:21Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-89b253e6788f4c7bad847a600e743e752024-04-14T11:20:26ZengNature PortfolioNature Communications2041-17232024-04-0115112410.1038/s41467-024-47459-2A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integrationSimon Weiler0Vahid Rahmati1Marcel Isstas2Johann Wutke3Andreas Walter Stark4Christian Franke5Jürgen Graf6Christian Geis7Otto W. Witte8Mark Hübener9Jürgen Bolz10Troy W. Margrie11Knut Holthoff12Manuel Teichert13Sainsbury Wellcome Centre for Neuronal Circuits and Behaviour, University College LondonJena University Hospital, Department of NeurologyFriedrich Schiller University Jena, Institute of General Zoology and Animal PhysiologyJena University Hospital, Department of NeurologyFriedrich Schiller University Jena, Institute of Applied Optics and BiophysicsFriedrich Schiller University Jena, Institute of Applied Optics and BiophysicsJena University Hospital, Department of NeurologyJena University Hospital, Department of NeurologyJena University Hospital, Department of NeurologyMax Planck Institute for Biological IntelligenceFriedrich Schiller University Jena, Institute of General Zoology and Animal PhysiologySainsbury Wellcome Centre for Neuronal Circuits and Behaviour, University College LondonJena University Hospital, Department of NeurologyJena University Hospital, Department of NeurologyAbstract Tactile sensation and vision are often both utilized for the exploration of objects that are within reach though it is not known whether or how these two distinct sensory systems combine such information. Here in mice, we used a combination of stereo photogrammetry for 3D reconstruction of the whisker array, brain-wide anatomical tracing and functional connectivity analysis to explore the possibility of tacto-visual convergence in sensory space and within the circuitry of the primary visual cortex (VISp). Strikingly, we find that stimulation of the contralateral whisker array suppresses visually evoked activity in a tacto-visual sub-region of VISp whose visual space representation closely overlaps with the whisker search space. This suppression is mediated by local fast-spiking interneurons that receive a direct cortico-cortical input predominantly from layer 6 neurons located in the posterior primary somatosensory barrel cortex (SSp-bfd). These data demonstrate functional convergence within and between two primary sensory cortical areas for multisensory object detection and recognition.https://doi.org/10.1038/s41467-024-47459-2 |
| spellingShingle | Simon Weiler Vahid Rahmati Marcel Isstas Johann Wutke Andreas Walter Stark Christian Franke Jürgen Graf Christian Geis Otto W. Witte Mark Hübener Jürgen Bolz Troy W. Margrie Knut Holthoff Manuel Teichert A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration Nature Communications |
| title | A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration |
| title_full | A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration |
| title_fullStr | A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration |
| title_full_unstemmed | A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration |
| title_short | A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration |
| title_sort | primary sensory cortical interareal feedforward inhibitory circuit for tacto visual integration |
| url | https://doi.org/10.1038/s41467-024-47459-2 |
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