Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links
Human tissues, to maintain their architecture and function, respond to injuries by activating intricate biochemical and physical mechanisms that regulates intercellular communication crucial in maintaining tissue homeostasis. Coordination of the communication occurs through the activity of different...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/11/2/336 |
| _version_ | 1827588446826266624 |
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| author | Roberta Melchionna Paola Trono Annalisa Tocci Paola Nisticò |
| author_facet | Roberta Melchionna Paola Trono Annalisa Tocci Paola Nisticò |
| author_sort | Roberta Melchionna |
| collection | DOAJ |
| description | Human tissues, to maintain their architecture and function, respond to injuries by activating intricate biochemical and physical mechanisms that regulates intercellular communication crucial in maintaining tissue homeostasis. Coordination of the communication occurs through the activity of different actin cytoskeletal regulators, physically connected to extracellular matrix through integrins, generating a platform of biochemical and biomechanical signaling that is deregulated in cancer. Among the major pathways, a controller of cellular functions is the cytokine transforming growth factor β (TGFβ), which remains a complex and central signaling network still to be interpreted and explained in cancer progression. Here, we discuss the link between actin dynamics and TGFβ signaling with the aim of exploring their aberrant interaction in cancer. |
| first_indexed | 2024-03-09T00:36:35Z |
| format | Article |
| id | doaj.art-89b3c3469d934614a56653738e5881fe |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T00:36:35Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-89b3c3469d934614a56653738e5881fe2023-12-11T18:08:47ZengMDPI AGBiomolecules2218-273X2021-02-0111233610.3390/biom11020336Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their LinksRoberta Melchionna0Paola Trono1Annalisa Tocci2Paola Nisticò3Tumor Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute, via Chianesi 53, 00144 Rome, ItalyTumor Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute, via Chianesi 53, 00144 Rome, ItalyTumor Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute, via Chianesi 53, 00144 Rome, ItalyTumor Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute, via Chianesi 53, 00144 Rome, ItalyHuman tissues, to maintain their architecture and function, respond to injuries by activating intricate biochemical and physical mechanisms that regulates intercellular communication crucial in maintaining tissue homeostasis. Coordination of the communication occurs through the activity of different actin cytoskeletal regulators, physically connected to extracellular matrix through integrins, generating a platform of biochemical and biomechanical signaling that is deregulated in cancer. Among the major pathways, a controller of cellular functions is the cytokine transforming growth factor β (TGFβ), which remains a complex and central signaling network still to be interpreted and explained in cancer progression. Here, we discuss the link between actin dynamics and TGFβ signaling with the aim of exploring their aberrant interaction in cancer.https://www.mdpi.com/2218-273X/11/2/336actin cytoskeletonactin-binding proteinsTGFβextracellular matrixtumor microenvironment |
| spellingShingle | Roberta Melchionna Paola Trono Annalisa Tocci Paola Nisticò Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links Biomolecules actin cytoskeleton actin-binding proteins TGFβ extracellular matrix tumor microenvironment |
| title | Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links |
| title_full | Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links |
| title_fullStr | Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links |
| title_full_unstemmed | Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links |
| title_short | Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links |
| title_sort | actin cytoskeleton and regulation of tgfβ signaling exploring their links |
| topic | actin cytoskeleton actin-binding proteins TGFβ extracellular matrix tumor microenvironment |
| url | https://www.mdpi.com/2218-273X/11/2/336 |
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