Elastic modulus-reflected liver lesion stiffness relates to worse prognosis in pancreatic cancer patients with liver metastasis
Abstract Background Liver stiffness relates to more advanced tumor status and poor outcomes in primary liver cancer, while its prognostic role in pancreatic cancer with liver metastasis is unclear. Therefore, the current study aimed to explore the correlation of elastic modulus (EM)-reflected liver...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-023-03140-4 |
| _version_ | 1797559342890745856 |
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| author | Shu Dong Xian Miao Ke Zhang Xiaoyan Zhu Yi Gao Hao Chen |
| author_facet | Shu Dong Xian Miao Ke Zhang Xiaoyan Zhu Yi Gao Hao Chen |
| author_sort | Shu Dong |
| collection | DOAJ |
| description | Abstract Background Liver stiffness relates to more advanced tumor status and poor outcomes in primary liver cancer, while its prognostic role in pancreatic cancer with liver metastasis is unclear. Therefore, the current study aimed to explore the correlation of elastic modulus (EM)-reflected liver lesion stiffness with clinical characteristics, tumor markers, and survival among pancreatic cancer patients with liver metastasis. Methods Fifty-four pancreatic cancer patients with liver metastasis were enrolled, and the EM of liver metastasis and peripheral liver tissue was measured by two-dimensional shear wave elastography. Relative EM was calculated as the ratio of EM in liver metastasis to that in peripheral liver tissue, which reflected the relative liver lesion stiffness. Results The median relative EM of liver metastasis was 7.8 (interquartile range: 4.8–10.7) folds. Relative EM of liver metastasis was correlated with primary pancreatic cancer location (P = 0.048), the presence of extra lung metastasis (P = 0.040), liver metastasis ≥ 3 cm (P = 0.007), and the absence of extraskeletal metastasis (P = 0.036); but it was not correlated with tumor markers such as CA199, CA125, or CEA (all P > 0.05). Encouragingly, high relative EM of liver metastasis (cut off by median value) was correlated with poor progression-free survival (PFS) (P = 0.032) but not overall survival (OS) (P = 0.285). Multivariable Cox analysis showed that high relative EM of liver metastasis (hazard ratio (HR) = 1.768, P = 0.048) and multiple metastases (HR = 2.262, P = 0.036) independently predicted decreased PFS, but only abnormal CEA independently forecasted decreased OS (HR = 2.390, P = 0.027). Conclusion Elastic modulus reflected liver lesion stiffness may predict a worse prognosis in pancreatic cancer patients with liver metastasis. |
| first_indexed | 2024-03-10T17:43:56Z |
| format | Article |
| id | doaj.art-89b558d9c91c4de8b532d42e6291cdce |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-03-10T17:43:56Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-89b558d9c91c4de8b532d42e6291cdce2023-11-20T09:37:05ZengBMCWorld Journal of Surgical Oncology1477-78192023-08-012111710.1186/s12957-023-03140-4Elastic modulus-reflected liver lesion stiffness relates to worse prognosis in pancreatic cancer patients with liver metastasisShu Dong0Xian Miao1Ke Zhang2Xiaoyan Zhu3Yi Gao4Hao Chen5Department of Integrative Oncology, Fudan University Shanghai Cancer CenterDepartment of Oncology, Nantong Hospital of Traditional Chinese MedicineDepartment of Integrative Oncology, Fudan University Shanghai Cancer CenterDepartment of Integrative Oncology, Fudan University Shanghai Cancer CenterDepartment of Medical Ultrasound, Fudan University Shanghai Cancer CenterDepartment of Integrative Oncology, Fudan University Shanghai Cancer CenterAbstract Background Liver stiffness relates to more advanced tumor status and poor outcomes in primary liver cancer, while its prognostic role in pancreatic cancer with liver metastasis is unclear. Therefore, the current study aimed to explore the correlation of elastic modulus (EM)-reflected liver lesion stiffness with clinical characteristics, tumor markers, and survival among pancreatic cancer patients with liver metastasis. Methods Fifty-four pancreatic cancer patients with liver metastasis were enrolled, and the EM of liver metastasis and peripheral liver tissue was measured by two-dimensional shear wave elastography. Relative EM was calculated as the ratio of EM in liver metastasis to that in peripheral liver tissue, which reflected the relative liver lesion stiffness. Results The median relative EM of liver metastasis was 7.8 (interquartile range: 4.8–10.7) folds. Relative EM of liver metastasis was correlated with primary pancreatic cancer location (P = 0.048), the presence of extra lung metastasis (P = 0.040), liver metastasis ≥ 3 cm (P = 0.007), and the absence of extraskeletal metastasis (P = 0.036); but it was not correlated with tumor markers such as CA199, CA125, or CEA (all P > 0.05). Encouragingly, high relative EM of liver metastasis (cut off by median value) was correlated with poor progression-free survival (PFS) (P = 0.032) but not overall survival (OS) (P = 0.285). Multivariable Cox analysis showed that high relative EM of liver metastasis (hazard ratio (HR) = 1.768, P = 0.048) and multiple metastases (HR = 2.262, P = 0.036) independently predicted decreased PFS, but only abnormal CEA independently forecasted decreased OS (HR = 2.390, P = 0.027). Conclusion Elastic modulus reflected liver lesion stiffness may predict a worse prognosis in pancreatic cancer patients with liver metastasis.https://doi.org/10.1186/s12957-023-03140-4Pancreatic cancerLiver metastasisElastic modulusStiffnessPrognosis |
| spellingShingle | Shu Dong Xian Miao Ke Zhang Xiaoyan Zhu Yi Gao Hao Chen Elastic modulus-reflected liver lesion stiffness relates to worse prognosis in pancreatic cancer patients with liver metastasis World Journal of Surgical Oncology Pancreatic cancer Liver metastasis Elastic modulus Stiffness Prognosis |
| title | Elastic modulus-reflected liver lesion stiffness relates to worse prognosis in pancreatic cancer patients with liver metastasis |
| title_full | Elastic modulus-reflected liver lesion stiffness relates to worse prognosis in pancreatic cancer patients with liver metastasis |
| title_fullStr | Elastic modulus-reflected liver lesion stiffness relates to worse prognosis in pancreatic cancer patients with liver metastasis |
| title_full_unstemmed | Elastic modulus-reflected liver lesion stiffness relates to worse prognosis in pancreatic cancer patients with liver metastasis |
| title_short | Elastic modulus-reflected liver lesion stiffness relates to worse prognosis in pancreatic cancer patients with liver metastasis |
| title_sort | elastic modulus reflected liver lesion stiffness relates to worse prognosis in pancreatic cancer patients with liver metastasis |
| topic | Pancreatic cancer Liver metastasis Elastic modulus Stiffness Prognosis |
| url | https://doi.org/10.1186/s12957-023-03140-4 |
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