Myo/Nog cells are nonprofessional phagocytes.
Myo/Nog cells were discovered in the chick embryo epiblast. Their expression of MyoD reflects a commitment to the skeletal muscle lineage and capacity to differentiate into myofibroblasts. Release of Noggin by Myo/Nog cells is essential for normal morphogenesis. Myo/Nog cells rapidly respond to woun...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0235898 |
| _version_ | 1818833715038519296 |
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| author | Jacquelyn Gerhart Lindsay Gugerty Paul Lecker Fathma Abdalla Mark Martin Olivia Gerhart Colby Gerhart Karanveer Johal Jake Bernstein John Spikes Keith Mathers Arturo Bravo-Nuevo Mindy George-Weinstein |
| author_facet | Jacquelyn Gerhart Lindsay Gugerty Paul Lecker Fathma Abdalla Mark Martin Olivia Gerhart Colby Gerhart Karanveer Johal Jake Bernstein John Spikes Keith Mathers Arturo Bravo-Nuevo Mindy George-Weinstein |
| author_sort | Jacquelyn Gerhart |
| collection | DOAJ |
| description | Myo/Nog cells were discovered in the chick embryo epiblast. Their expression of MyoD reflects a commitment to the skeletal muscle lineage and capacity to differentiate into myofibroblasts. Release of Noggin by Myo/Nog cells is essential for normal morphogenesis. Myo/Nog cells rapidly respond to wounding in the skin and eyes. In this report, we present evidence suggesting that Myo/Nog cells phagocytose tattoo ink in tissue sections of human skin and engulf cell corpses in cultures of anterior human lens tissue and magnetic beads injected into the anterior chamber of mice in vivo. Myo/Nog cells are distinct from macrophages in the skin and eyes indicated by the absence of labeling with an antibody to ionized calcium binding adaptor molecule 1. In addition to their primary roles as regulators of BMP signaling and progenitors of myofibroblasts, Myo/Nog cells behave as nonprofessional phagocytes defined as cells whose primary functions are unrelated to phagocytosis but are capable of engulfment. |
| first_indexed | 2024-12-19T02:23:19Z |
| format | Article |
| id | doaj.art-89b5bb07abde417b9557106d78ecec51 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T02:23:19Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-89b5bb07abde417b9557106d78ecec512022-12-21T20:40:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01158e023589810.1371/journal.pone.0235898Myo/Nog cells are nonprofessional phagocytes.Jacquelyn GerhartLindsay GugertyPaul LeckerFathma AbdallaMark MartinOlivia GerhartColby GerhartKaranveer JohalJake BernsteinJohn SpikesKeith MathersArturo Bravo-NuevoMindy George-WeinsteinMyo/Nog cells were discovered in the chick embryo epiblast. Their expression of MyoD reflects a commitment to the skeletal muscle lineage and capacity to differentiate into myofibroblasts. Release of Noggin by Myo/Nog cells is essential for normal morphogenesis. Myo/Nog cells rapidly respond to wounding in the skin and eyes. In this report, we present evidence suggesting that Myo/Nog cells phagocytose tattoo ink in tissue sections of human skin and engulf cell corpses in cultures of anterior human lens tissue and magnetic beads injected into the anterior chamber of mice in vivo. Myo/Nog cells are distinct from macrophages in the skin and eyes indicated by the absence of labeling with an antibody to ionized calcium binding adaptor molecule 1. In addition to their primary roles as regulators of BMP signaling and progenitors of myofibroblasts, Myo/Nog cells behave as nonprofessional phagocytes defined as cells whose primary functions are unrelated to phagocytosis but are capable of engulfment.https://doi.org/10.1371/journal.pone.0235898 |
| spellingShingle | Jacquelyn Gerhart Lindsay Gugerty Paul Lecker Fathma Abdalla Mark Martin Olivia Gerhart Colby Gerhart Karanveer Johal Jake Bernstein John Spikes Keith Mathers Arturo Bravo-Nuevo Mindy George-Weinstein Myo/Nog cells are nonprofessional phagocytes. PLoS ONE |
| title | Myo/Nog cells are nonprofessional phagocytes. |
| title_full | Myo/Nog cells are nonprofessional phagocytes. |
| title_fullStr | Myo/Nog cells are nonprofessional phagocytes. |
| title_full_unstemmed | Myo/Nog cells are nonprofessional phagocytes. |
| title_short | Myo/Nog cells are nonprofessional phagocytes. |
| title_sort | myo nog cells are nonprofessional phagocytes |
| url | https://doi.org/10.1371/journal.pone.0235898 |
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