The Prognostic Value of Low Muscle Mass in Pancreatic Cancer Patients: A Systematic Review and Meta-Analysis
Low muscle mass is associated with reduced survival in patients with different cancer types. The interest in preoperative sarcopenia and pancreatic cancer has risen in the last decade as muscle mass loss seems to be associated with poorer survival, higher postoperative morbidity, and mortality. The...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/14/3033 |
| _version_ | 1797526866725175296 |
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| author | Elisa Sefora Pierobon Lucia Moletta Sandra Zampieri Roberta Sartori Alessandra Rosalba Brazzale Gianpietro Zanchettin Simone Serafini Giovanni Capovilla Michele Valmasoni Stefano Merigliano Cosimo Sperti |
| author_facet | Elisa Sefora Pierobon Lucia Moletta Sandra Zampieri Roberta Sartori Alessandra Rosalba Brazzale Gianpietro Zanchettin Simone Serafini Giovanni Capovilla Michele Valmasoni Stefano Merigliano Cosimo Sperti |
| author_sort | Elisa Sefora Pierobon |
| collection | DOAJ |
| description | Low muscle mass is associated with reduced survival in patients with different cancer types. The interest in preoperative sarcopenia and pancreatic cancer has risen in the last decade as muscle mass loss seems to be associated with poorer survival, higher postoperative morbidity, and mortality. The aim of the present study was to review the literature to compare the impact of low muscle mass on the outcomes of patients undergoing surgery for pancreatic adenocarcinoma. An extensive literature review was conducted according to the 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and 10 articles were analyzed in detail and included in the meta-analysis. Data were retrieved on 2811 patients undergoing surgery for pancreatic cancer. Meta-analysis identified that patients with low muscle mass demonstrated a significantly reduced OS when compared to patients without alterations of the muscle mass (ROM 0.86; 95% CI: 0.81–0.91, <i>p</i> < 0.001), resulting in a 14% loss for the former. Meta-analysis failed to identify an increase in the postoperative complications and length of stay of patients with low muscle mass. Our analysis confirms the role of low muscle mass in influencing oncologic outcomes in pancreatic cancer. Its role on surgical outcomes remains to be established. |
| first_indexed | 2024-03-10T09:35:27Z |
| format | Article |
| id | doaj.art-89b5f6f74f4b4a389d059f637ffa40f3 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:35:27Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-89b5f6f74f4b4a389d059f637ffa40f32023-11-22T04:05:40ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-011014303310.3390/jcm10143033The Prognostic Value of Low Muscle Mass in Pancreatic Cancer Patients: A Systematic Review and Meta-AnalysisElisa Sefora Pierobon0Lucia Moletta1Sandra Zampieri2Roberta Sartori3Alessandra Rosalba Brazzale4Gianpietro Zanchettin5Simone Serafini6Giovanni Capovilla7Michele Valmasoni8Stefano Merigliano9Cosimo Sperti10Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padua, ItalyDepartment of Biomedical Sciences, University of Padua, Via U. Bassi 58/B, 35121 Padua, ItalyDepartment of Statistical Sciences, University of Padua, Via C. Battisti 241, 35121 Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padua, ItalyLow muscle mass is associated with reduced survival in patients with different cancer types. The interest in preoperative sarcopenia and pancreatic cancer has risen in the last decade as muscle mass loss seems to be associated with poorer survival, higher postoperative morbidity, and mortality. The aim of the present study was to review the literature to compare the impact of low muscle mass on the outcomes of patients undergoing surgery for pancreatic adenocarcinoma. An extensive literature review was conducted according to the 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and 10 articles were analyzed in detail and included in the meta-analysis. Data were retrieved on 2811 patients undergoing surgery for pancreatic cancer. Meta-analysis identified that patients with low muscle mass demonstrated a significantly reduced OS when compared to patients without alterations of the muscle mass (ROM 0.86; 95% CI: 0.81–0.91, <i>p</i> < 0.001), resulting in a 14% loss for the former. Meta-analysis failed to identify an increase in the postoperative complications and length of stay of patients with low muscle mass. Our analysis confirms the role of low muscle mass in influencing oncologic outcomes in pancreatic cancer. Its role on surgical outcomes remains to be established.https://www.mdpi.com/2077-0383/10/14/3033low muscle masssarcopeniapancreatic adenocarcinomapancreatic cancerpancreatic surgerybody composition |
| spellingShingle | Elisa Sefora Pierobon Lucia Moletta Sandra Zampieri Roberta Sartori Alessandra Rosalba Brazzale Gianpietro Zanchettin Simone Serafini Giovanni Capovilla Michele Valmasoni Stefano Merigliano Cosimo Sperti The Prognostic Value of Low Muscle Mass in Pancreatic Cancer Patients: A Systematic Review and Meta-Analysis Journal of Clinical Medicine low muscle mass sarcopenia pancreatic adenocarcinoma pancreatic cancer pancreatic surgery body composition |
| title | The Prognostic Value of Low Muscle Mass in Pancreatic Cancer Patients: A Systematic Review and Meta-Analysis |
| title_full | The Prognostic Value of Low Muscle Mass in Pancreatic Cancer Patients: A Systematic Review and Meta-Analysis |
| title_fullStr | The Prognostic Value of Low Muscle Mass in Pancreatic Cancer Patients: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Prognostic Value of Low Muscle Mass in Pancreatic Cancer Patients: A Systematic Review and Meta-Analysis |
| title_short | The Prognostic Value of Low Muscle Mass in Pancreatic Cancer Patients: A Systematic Review and Meta-Analysis |
| title_sort | prognostic value of low muscle mass in pancreatic cancer patients a systematic review and meta analysis |
| topic | low muscle mass sarcopenia pancreatic adenocarcinoma pancreatic cancer pancreatic surgery body composition |
| url | https://www.mdpi.com/2077-0383/10/14/3033 |
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