Chlorogenic Acid Ameliorates Post‐Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut Microbes
Abstract Post‐infectious irritable bowel syndrome (PI‐IBS) occurs after acute infectious diarrhea, and dysbiosis can be involved in its pathogenesis. Here, the role of chlorogenic acid (CGA) is investigated, a natural compound with several pharmacological properties, in alleviating PI‐IBS in rats. I...
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202302798 |
| _version_ | 1827797370884063232 |
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| author | Cihua Zheng Yuchun Zhong Wenming Zhang Zhuoya Wang Haili Xiao Wenjun Zhang Jian Xie Xiaogang Peng Jun Luo Wei Xu |
| author_facet | Cihua Zheng Yuchun Zhong Wenming Zhang Zhuoya Wang Haili Xiao Wenjun Zhang Jian Xie Xiaogang Peng Jun Luo Wei Xu |
| author_sort | Cihua Zheng |
| collection | DOAJ |
| description | Abstract Post‐infectious irritable bowel syndrome (PI‐IBS) occurs after acute infectious diarrhea, and dysbiosis can be involved in its pathogenesis. Here, the role of chlorogenic acid (CGA) is investigated, a natural compound with several pharmacological properties, in alleviating PI‐IBS in rats. It is elucidated that the gut microbiota plays a key role in PI‐IBS pathogenesis and that rectal administration of CGA alleviated PI‐IBS by modulating the gut microbiota and its metabolites. CGA supplementation significantly increased fecal Bacteroides acidifaciens abundance and glycine levels. Glycine structurally altered B. acidifaciens extracellular vesicles (EVs) and enriched functional proteins in the EVs; glycine‐induced EVs alleviated PI‐IBS by reducing inflammation and hypersensitivity of the intestinal viscera and maintaining mucosal barrier function. Moreover, B. acidifaciens EVs are enriched in the brain tissue. Thus, CGA mediates the mitigation of PI‐IBS through the gut microbiota and its metabolites. This study proposes a novel mechanism of signal exchange between the gut microenvironment and the host. |
| first_indexed | 2024-03-11T19:22:13Z |
| format | Article |
| id | doaj.art-89b61a0a1cc84a2090e5b37781901efb |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-11T19:22:13Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-89b61a0a1cc84a2090e5b37781901efb2023-10-07T03:51:50ZengWileyAdvanced Science2198-38442023-10-011028n/an/a10.1002/advs.202302798Chlorogenic Acid Ameliorates Post‐Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut MicrobesCihua Zheng0Yuchun Zhong1Wenming Zhang2Zhuoya Wang3Haili Xiao4Wenjun Zhang5Jian Xie6Xiaogang Peng7Jun Luo8Wei Xu9Department of General Surgery The Second Affiliated Hospital of Nanchang University 1 Minde Road Nanchang Jiangxi 330006 P. R. ChinaDepartment of General Surgery The Second Affiliated Hospital of Nanchang University 1 Minde Road Nanchang Jiangxi 330006 P. R. ChinaDepartment of General Surgery The Second Affiliated Hospital of Nanchang University 1 Minde Road Nanchang Jiangxi 330006 P. R. ChinaDepartment of Rehabilitation Medicine The Second Affiliated Hospital of Nanchang University 1 Minde Road Nanchang Jiangxi 330006 P. R. ChinaDepartment of Rehabilitation Medicine The Second Affiliated Hospital of Nanchang University 1 Minde Road Nanchang Jiangxi 330006 P. R. ChinaDepartment of Rehabilitation Medicine The Second Affiliated Hospital of Nanchang University 1 Minde Road Nanchang Jiangxi 330006 P. R. ChinaDepartment of Rehabilitation Medicine The Second Affiliated Hospital of Nanchang University 1 Minde Road Nanchang Jiangxi 330006 P. R. ChinaJiangxi Province Key Laboratory of Molecular Medicine The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 P. R. ChinaDepartment of Rehabilitation Medicine The Second Affiliated Hospital of Nanchang University 1 Minde Road Nanchang Jiangxi 330006 P. R. ChinaDepartment of General Surgery The Second Affiliated Hospital of Nanchang University 1 Minde Road Nanchang Jiangxi 330006 P. R. ChinaAbstract Post‐infectious irritable bowel syndrome (PI‐IBS) occurs after acute infectious diarrhea, and dysbiosis can be involved in its pathogenesis. Here, the role of chlorogenic acid (CGA) is investigated, a natural compound with several pharmacological properties, in alleviating PI‐IBS in rats. It is elucidated that the gut microbiota plays a key role in PI‐IBS pathogenesis and that rectal administration of CGA alleviated PI‐IBS by modulating the gut microbiota and its metabolites. CGA supplementation significantly increased fecal Bacteroides acidifaciens abundance and glycine levels. Glycine structurally altered B. acidifaciens extracellular vesicles (EVs) and enriched functional proteins in the EVs; glycine‐induced EVs alleviated PI‐IBS by reducing inflammation and hypersensitivity of the intestinal viscera and maintaining mucosal barrier function. Moreover, B. acidifaciens EVs are enriched in the brain tissue. Thus, CGA mediates the mitigation of PI‐IBS through the gut microbiota and its metabolites. This study proposes a novel mechanism of signal exchange between the gut microenvironment and the host.https://doi.org/10.1002/advs.202302798PI‐IBSbacteroides acidifacienschlorogenic acidextracellular vesiclesglycine |
| spellingShingle | Cihua Zheng Yuchun Zhong Wenming Zhang Zhuoya Wang Haili Xiao Wenjun Zhang Jian Xie Xiaogang Peng Jun Luo Wei Xu Chlorogenic Acid Ameliorates Post‐Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut Microbes Advanced Science PI‐IBS bacteroides acidifaciens chlorogenic acid extracellular vesicles glycine |
| title | Chlorogenic Acid Ameliorates Post‐Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut Microbes |
| title_full | Chlorogenic Acid Ameliorates Post‐Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut Microbes |
| title_fullStr | Chlorogenic Acid Ameliorates Post‐Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut Microbes |
| title_full_unstemmed | Chlorogenic Acid Ameliorates Post‐Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut Microbes |
| title_short | Chlorogenic Acid Ameliorates Post‐Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut Microbes |
| title_sort | chlorogenic acid ameliorates post infectious irritable bowel syndrome by regulating extracellular vesicles of gut microbes |
| topic | PI‐IBS bacteroides acidifaciens chlorogenic acid extracellular vesicles glycine |
| url | https://doi.org/10.1002/advs.202302798 |
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