Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectives
The osteochondral defect repair has been most extensively studied due to the rising demand for new therapies to diseases such as osteoarthritis. Tissue engineering has been proposed as a promising strategy to meet the demand of simultaneous regeneration of both cartilage and subchondral bone by cons...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-02-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X22002778 |
| _version_ | 1797204816509796352 |
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| author | Xiaolian Niu Ning Li Zhipo Du Xiaoming Li |
| author_facet | Xiaolian Niu Ning Li Zhipo Du Xiaoming Li |
| author_sort | Xiaolian Niu |
| collection | DOAJ |
| description | The osteochondral defect repair has been most extensively studied due to the rising demand for new therapies to diseases such as osteoarthritis. Tissue engineering has been proposed as a promising strategy to meet the demand of simultaneous regeneration of both cartilage and subchondral bone by constructing integrated gradient tissue-engineered osteochondral scaffold (IGTEOS). This review brought forward the main challenges of establishing a satisfactory IGTEOS from the perspectives of the complexity of physiology and microenvironment of osteochondral tissue, and the limitations of obtaining the desired and required scaffold. Then, we comprehensively discussed and summarized the current tissue-engineered efforts to resolve the above challenges, including architecture strategies, fabrication techniques and in vitro/in vivo evaluation methods of the IGTEOS. Especially, we highlighted the advantages and limitations of various fabrication techniques of IGTEOS, and common cases of IGTEOS application. Finally, based on the above challenges and current research progress, we analyzed in details the future perspectives of tissue-engineered osteochondral construct, so as to achieve the perfect reconstruction of the cartilaginous and osseous layers of osteochondral tissue simultaneously. This comprehensive and instructive review could provide deep insights into our current understanding of IGTEOS. |
| first_indexed | 2024-04-11T23:59:44Z |
| format | Article |
| id | doaj.art-89b784e46ee248d996ac5a0ca6a806c0 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:41:14Z |
| publishDate | 2023-02-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-89b784e46ee248d996ac5a0ca6a806c02024-04-16T15:59:09ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-02-0120574597Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectivesXiaolian Niu0Ning Li1Zhipo Du2Xiaoming Li3Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, ChinaDepartment of Orthopedics, The Fourth Central Hospital of Baoding City, Baoding, 072350, ChinaDepartment of Orthopedics, The Fourth Central Hospital of Baoding City, Baoding, 072350, China; Corresponding author.Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China; Corresponding author.The osteochondral defect repair has been most extensively studied due to the rising demand for new therapies to diseases such as osteoarthritis. Tissue engineering has been proposed as a promising strategy to meet the demand of simultaneous regeneration of both cartilage and subchondral bone by constructing integrated gradient tissue-engineered osteochondral scaffold (IGTEOS). This review brought forward the main challenges of establishing a satisfactory IGTEOS from the perspectives of the complexity of physiology and microenvironment of osteochondral tissue, and the limitations of obtaining the desired and required scaffold. Then, we comprehensively discussed and summarized the current tissue-engineered efforts to resolve the above challenges, including architecture strategies, fabrication techniques and in vitro/in vivo evaluation methods of the IGTEOS. Especially, we highlighted the advantages and limitations of various fabrication techniques of IGTEOS, and common cases of IGTEOS application. Finally, based on the above challenges and current research progress, we analyzed in details the future perspectives of tissue-engineered osteochondral construct, so as to achieve the perfect reconstruction of the cartilaginous and osseous layers of osteochondral tissue simultaneously. This comprehensive and instructive review could provide deep insights into our current understanding of IGTEOS.http://www.sciencedirect.com/science/article/pii/S2452199X22002778Osteochondral tissue engineeringIntegrated gradient tissue-engineered osteochondral scaffold (IGTEOS)Tissue-engineered strategiesFabrication techniquesEvaluation |
| spellingShingle | Xiaolian Niu Ning Li Zhipo Du Xiaoming Li Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectives Bioactive Materials Osteochondral tissue engineering Integrated gradient tissue-engineered osteochondral scaffold (IGTEOS) Tissue-engineered strategies Fabrication techniques Evaluation |
| title | Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectives |
| title_full | Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectives |
| title_fullStr | Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectives |
| title_full_unstemmed | Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectives |
| title_short | Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectives |
| title_sort | integrated gradient tissue engineered osteochondral scaffolds challenges current efforts and future perspectives |
| topic | Osteochondral tissue engineering Integrated gradient tissue-engineered osteochondral scaffold (IGTEOS) Tissue-engineered strategies Fabrication techniques Evaluation |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X22002778 |
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