Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in gambling disorder and alcohol use disorder
Abstract Striatal dysfunction is a key characteristic of addictive disorders, but neuroimaging studies have reported conflicting findings. An integrative model of addiction points to the presence or absence of addiction-related cues as an explanation for striatal hypo- or hyperactivations, respect...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-03-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823000366/type/journal_article |
| _version_ | 1797617285197725696 |
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| author | A. Goudriaan |
| author_facet | A. Goudriaan |
| author_sort | A. Goudriaan |
| collection | DOAJ |
| description |
Abstract
Striatal dysfunction is a key characteristic of addictive disorders, but neuroimaging studies have reported conflicting findings. An integrative model of addiction points to the presence or absence of addiction-related cues as an explanation for striatal hypo- or hyperactivations, respectively, but has never been directly tested. Here, we developed a novel paradigm to investigate striatal activation during monetary reward anticipation in the presence versus absence of addiction-related pictures using functional MRI. Across two studies, we compared 24 gambling disorder (GD) patients with 22 matched healthy controls and 46 alcohol use disorder (AUD) patients with 30 matched healthy controls. A behavioral interaction was seen where gambling cues made participants respond faster for bigger, but slower for smaller rewards. During monetary reward anticipation, hypoactivation of the reward system was seen in AUD individuals compared to HCs. However, no striatal differences were seen between the participants with GD or AUD and their matched controls. In sum, these findings suggest that striatal dysfunction is a key but heterogeneous mechanism within both AUD and GD and indicate an important but complex role for addiction-related cues in explaining striatal dysfunction in addiction.
Disclosure of Interest
None Declared |
| first_indexed | 2024-03-11T07:53:39Z |
| format | Article |
| id | doaj.art-89b79ce332bc4100a477afa0e9869d0b |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:53:39Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-89b79ce332bc4100a477afa0e9869d0b2023-11-17T05:06:13ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-03-0166S5S610.1192/j.eurpsy.2023.36Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in gambling disorder and alcohol use disorderA. Goudriaan0Psychiatry, Amsterdam University Medical Centers, Amsterdam, Netherlands Abstract Striatal dysfunction is a key characteristic of addictive disorders, but neuroimaging studies have reported conflicting findings. An integrative model of addiction points to the presence or absence of addiction-related cues as an explanation for striatal hypo- or hyperactivations, respectively, but has never been directly tested. Here, we developed a novel paradigm to investigate striatal activation during monetary reward anticipation in the presence versus absence of addiction-related pictures using functional MRI. Across two studies, we compared 24 gambling disorder (GD) patients with 22 matched healthy controls and 46 alcohol use disorder (AUD) patients with 30 matched healthy controls. A behavioral interaction was seen where gambling cues made participants respond faster for bigger, but slower for smaller rewards. During monetary reward anticipation, hypoactivation of the reward system was seen in AUD individuals compared to HCs. However, no striatal differences were seen between the participants with GD or AUD and their matched controls. In sum, these findings suggest that striatal dysfunction is a key but heterogeneous mechanism within both AUD and GD and indicate an important but complex role for addiction-related cues in explaining striatal dysfunction in addiction. Disclosure of Interest None Declaredhttps://www.cambridge.org/core/product/identifier/S0924933823000366/type/journal_article |
| spellingShingle | A. Goudriaan Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in gambling disorder and alcohol use disorder European Psychiatry |
| title | Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in gambling disorder and alcohol use disorder |
| title_full | Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in gambling disorder and alcohol use disorder |
| title_fullStr | Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in gambling disorder and alcohol use disorder |
| title_full_unstemmed | Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in gambling disorder and alcohol use disorder |
| title_short | Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in gambling disorder and alcohol use disorder |
| title_sort | striatal ups or downs neural correlates of monetary reward anticipation cue reactivity and their interaction in gambling disorder and alcohol use disorder |
| url | https://www.cambridge.org/core/product/identifier/S0924933823000366/type/journal_article |
| work_keys_str_mv | AT agoudriaan striatalupsordownsneuralcorrelatesofmonetaryrewardanticipationcuereactivityandtheirinteractioningamblingdisorderandalcoholusedisorder |