The role of NLRP3 inflammasome in aging and age-related diseases
Abstract The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated to understanding and coping with the complexities of aging, constantly uncovering the substances and mechanism related to aging like chroni...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Immunity & Ageing |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12979-023-00395-z |
| _version_ | 1827326184631828480 |
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| author | Ruikai Liang Xinrui Qi Qi Cai Liyan Niu Xi Huang Deju Zhang Jitao Ling Yuting Wu Yixuan Chen Pingping Yang Jianping Liu Jing Zhang Peng Yu |
| author_facet | Ruikai Liang Xinrui Qi Qi Cai Liyan Niu Xi Huang Deju Zhang Jitao Ling Yuting Wu Yixuan Chen Pingping Yang Jianping Liu Jing Zhang Peng Yu |
| author_sort | Ruikai Liang |
| collection | DOAJ |
| description | Abstract The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated to understanding and coping with the complexities of aging, constantly uncovering the substances and mechanism related to aging like chronic low-grade inflammation. The NOD-like receptor protein 3 (NLRP3), a key regulator of the innate immune response, recognizes molecular patterns associated with pathogens and injury, initiating an intrinsic inflammatory immune response. Dysfunctional NLRP3 is linked to the onset of related diseases, particularly in the context of aging. Therefore, a profound comprehension of the regulatory mechanisms of the NLRP3 inflammasome in aging-related diseases holds the potential to enhance treatment strategies for these conditions. In this article, we review the significance of the NLRP3 inflammasome in the initiation and progression of diverse aging-related diseases. Furthermore, we explore preventive and therapeutic strategies for aging and related diseases by manipulating the NLRP3 inflammasome, along with its upstream and downstream mechanisms. |
| first_indexed | 2024-03-07T14:40:54Z |
| format | Article |
| id | doaj.art-89b9f70fceb94545921c1a2881b76526 |
| institution | Directory Open Access Journal |
| issn | 1742-4933 |
| language | English |
| last_indexed | 2024-03-07T14:40:54Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Immunity & Ageing |
| spelling | doaj.art-89b9f70fceb94545921c1a2881b765262024-03-05T20:21:43ZengBMCImmunity & Ageing1742-49332024-02-0121111610.1186/s12979-023-00395-zThe role of NLRP3 inflammasome in aging and age-related diseasesRuikai Liang0Xinrui Qi1Qi Cai2Liyan Niu3Xi Huang4Deju Zhang5Jitao Ling6Yuting Wu7Yixuan Chen8Pingping Yang9Jianping Liu10Jing Zhang11Peng Yu12Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang UniversityDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang UniversityDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang UniversityHuan Kui College of Nanchang UniversityThe Second Clinical Medical College of Nanchang University, The Second Affiliated Hospital of Nanchang UniversityFood and Nutritional Sciences, School of Biological Sciences, The University of Hong KongDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang UniversityDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang UniversityDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang UniversityDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang UniversityDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang UniversityDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang UniversityDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang UniversityAbstract The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated to understanding and coping with the complexities of aging, constantly uncovering the substances and mechanism related to aging like chronic low-grade inflammation. The NOD-like receptor protein 3 (NLRP3), a key regulator of the innate immune response, recognizes molecular patterns associated with pathogens and injury, initiating an intrinsic inflammatory immune response. Dysfunctional NLRP3 is linked to the onset of related diseases, particularly in the context of aging. Therefore, a profound comprehension of the regulatory mechanisms of the NLRP3 inflammasome in aging-related diseases holds the potential to enhance treatment strategies for these conditions. In this article, we review the significance of the NLRP3 inflammasome in the initiation and progression of diverse aging-related diseases. Furthermore, we explore preventive and therapeutic strategies for aging and related diseases by manipulating the NLRP3 inflammasome, along with its upstream and downstream mechanisms.https://doi.org/10.1186/s12979-023-00395-zNLRP3 inflammasomeAgingRelated diseasesRegulatory mechanismsTherapeutic strategies |
| spellingShingle | Ruikai Liang Xinrui Qi Qi Cai Liyan Niu Xi Huang Deju Zhang Jitao Ling Yuting Wu Yixuan Chen Pingping Yang Jianping Liu Jing Zhang Peng Yu The role of NLRP3 inflammasome in aging and age-related diseases Immunity & Ageing NLRP3 inflammasome Aging Related diseases Regulatory mechanisms Therapeutic strategies |
| title | The role of NLRP3 inflammasome in aging and age-related diseases |
| title_full | The role of NLRP3 inflammasome in aging and age-related diseases |
| title_fullStr | The role of NLRP3 inflammasome in aging and age-related diseases |
| title_full_unstemmed | The role of NLRP3 inflammasome in aging and age-related diseases |
| title_short | The role of NLRP3 inflammasome in aging and age-related diseases |
| title_sort | role of nlrp3 inflammasome in aging and age related diseases |
| topic | NLRP3 inflammasome Aging Related diseases Regulatory mechanisms Therapeutic strategies |
| url | https://doi.org/10.1186/s12979-023-00395-z |
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