The enigmatic role of nucleophosmin in malignant melanoma: Does it have an effect?
Background: Melanoma is quite a heterogeneous group of diseases of the skin. Prognostic markers of tumor behavior are important to precisely assign individual patients for appropriate treatment protocols. Aim: The aim of our first study was to investigate nucleophosmin expression in melanoma patient...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=482;epage=486;aulast=Calli |
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| author | Aylin Orgen Calli Aysegül Sari Gözde Evcim Aysegül Altinboga Canan Sadullahoglu Murat Ermete |
| author_facet | Aylin Orgen Calli Aysegül Sari Gözde Evcim Aysegül Altinboga Canan Sadullahoglu Murat Ermete |
| author_sort | Aylin Orgen Calli |
| collection | DOAJ |
| description | Background: Melanoma is quite a heterogeneous group of diseases of the skin. Prognostic markers of tumor behavior are important to precisely assign individual patients for appropriate treatment protocols. Aim: The aim of our first study was to investigate nucleophosmin expression in melanoma patients and to determine its relationship with the tumor characterictics and patient prognosis. Materials and Methods: We analyzed the immunohistochemical expression of nucleophosmin in 55 melanoma patients. The immunostaining pattern was classified into two groups: Diffuse nuclear and nucleolar relocalization. We also investigated the relationship between the expression of nucleophosmin and the clinicopathological parameters sucssh as Clark level, tumor thickness, stage, histological type, location, and survey. Results: In all cases the neoplastic cells were strongly positive for nucleophosmin (14 cases diffuse nuclear, 41 cases nucleolar relocalization). No correlation was demonstrated between the expression pattern of nucleophosmin and the clinicopathological parameters and survey. Conclusions: The implications of our results, nevertheless, are that the immunohistochemical detection of nucleophosmin is not a valuable tool for predicting the outcome of patients with melanoma or identifying subgroups of patients who may be at a higher risk. |
| first_indexed | 2024-04-12T06:42:40Z |
| format | Article |
| id | doaj.art-89ba9863d2c64cb592679ca7582ea8ee |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-04-12T06:42:40Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-89ba9863d2c64cb592679ca7582ea8ee2022-12-22T03:43:41ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292011-01-0154348248610.4103/0377-4929.85079The enigmatic role of nucleophosmin in malignant melanoma: Does it have an effect?Aylin Orgen CalliAysegül SariGözde EvcimAysegül AltinbogaCanan SadullahogluMurat ErmeteBackground: Melanoma is quite a heterogeneous group of diseases of the skin. Prognostic markers of tumor behavior are important to precisely assign individual patients for appropriate treatment protocols. Aim: The aim of our first study was to investigate nucleophosmin expression in melanoma patients and to determine its relationship with the tumor characterictics and patient prognosis. Materials and Methods: We analyzed the immunohistochemical expression of nucleophosmin in 55 melanoma patients. The immunostaining pattern was classified into two groups: Diffuse nuclear and nucleolar relocalization. We also investigated the relationship between the expression of nucleophosmin and the clinicopathological parameters sucssh as Clark level, tumor thickness, stage, histological type, location, and survey. Results: In all cases the neoplastic cells were strongly positive for nucleophosmin (14 cases diffuse nuclear, 41 cases nucleolar relocalization). No correlation was demonstrated between the expression pattern of nucleophosmin and the clinicopathological parameters and survey. Conclusions: The implications of our results, nevertheless, are that the immunohistochemical detection of nucleophosmin is not a valuable tool for predicting the outcome of patients with melanoma or identifying subgroups of patients who may be at a higher risk.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=482;epage=486;aulast=CalliB23malignant melanomanucleophosminprognosis |
| spellingShingle | Aylin Orgen Calli Aysegül Sari Gözde Evcim Aysegül Altinboga Canan Sadullahoglu Murat Ermete The enigmatic role of nucleophosmin in malignant melanoma: Does it have an effect? Indian Journal of Pathology and Microbiology B23 malignant melanoma nucleophosmin prognosis |
| title | The enigmatic role of nucleophosmin in malignant melanoma: Does it have an effect? |
| title_full | The enigmatic role of nucleophosmin in malignant melanoma: Does it have an effect? |
| title_fullStr | The enigmatic role of nucleophosmin in malignant melanoma: Does it have an effect? |
| title_full_unstemmed | The enigmatic role of nucleophosmin in malignant melanoma: Does it have an effect? |
| title_short | The enigmatic role of nucleophosmin in malignant melanoma: Does it have an effect? |
| title_sort | enigmatic role of nucleophosmin in malignant melanoma does it have an effect |
| topic | B23 malignant melanoma nucleophosmin prognosis |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=482;epage=486;aulast=Calli |
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