Hair-Based Assessment of Sex Steroid Hormones in Patients with Anorexia Nervosa
Anorexia nervosa (AN) is a complex psychiatric disorder accompanied by a variety of endocrine effects. Altered levels of the sex steroid hormones progesterone and dehydroepiandrosterone (DHEA) have been shown to occur in patients with AN using short-term hormonal measurement methods based on blood,...
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MDPI AG
2022-12-01
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| Online Access: | https://www.mdpi.com/2218-1989/13/1/21 |
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| author | Victoria-Luise Batury Friederike I. Tam Inger Hellerhoff Marie-Louis Wronski Katrin Borucki Kerstin Weidner Veit Roessner Wei Gao Stefan Ehrlich |
| author_facet | Victoria-Luise Batury Friederike I. Tam Inger Hellerhoff Marie-Louis Wronski Katrin Borucki Kerstin Weidner Veit Roessner Wei Gao Stefan Ehrlich |
| author_sort | Victoria-Luise Batury |
| collection | DOAJ |
| description | Anorexia nervosa (AN) is a complex psychiatric disorder accompanied by a variety of endocrine effects. Altered levels of the sex steroid hormones progesterone and dehydroepiandrosterone (DHEA) have been shown to occur in patients with AN using short-term hormonal measurement methods based on blood, saliva, and urine samples. However, since sex steroid hormone levels fluctuate during the menstrual cycle, these measurement methods require a great deal of effort due to the need to collect multiple samples in order to correctly determine the basal level of sex hormones. In contrast, hair-based assessments provide a marker of accumulated longer-term hormone exposure using a single, non-invasive sample. The aim of this study was to investigate sex steroid hormone levels via hair-based assessments in acutely underweight AN in comparison with healthy, age-matched, female control participants. Additionally, we compared progesterone and DHEA hair levels longitudinally during inpatient treatment in AN. Collected hair samples were analyzed using liquid chromatography-mass spectrometry (LC-MS/MS) to determine a monthly hormone level of progesterone and DHEA. Our results indicate that DHEA hair hormone levels were similar across groups but progesterone was suppressed in underweight AN compared with healthy controls. In the longitudinal design, no significant change in hair hormone levels during partial weight restoration in patients with AN was observed. Our findings suggest that hair analysis can be used to detect suppressed progesterone levels in severe AN, and that progesterone does not increase during short-term weight restoration. |
| first_indexed | 2024-03-09T11:43:39Z |
| format | Article |
| id | doaj.art-89bb1e70757145048bc4c7a549d06dfd |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T11:43:39Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-89bb1e70757145048bc4c7a549d06dfd2023-11-30T23:27:45ZengMDPI AGMetabolites2218-19892022-12-011312110.3390/metabo13010021Hair-Based Assessment of Sex Steroid Hormones in Patients with Anorexia NervosaVictoria-Luise Batury0Friederike I. Tam1Inger Hellerhoff2Marie-Louis Wronski3Katrin Borucki4Kerstin Weidner5Veit Roessner6Wei Gao7Stefan Ehrlich8Division of Psychological and Social Medicine and Developmental Neurosciences, Translational Developmental Neuroscience Section, University Hospital C.G. Carus, Technische Universität Dresden, 01307 Dresden, GermanyDivision of Psychological and Social Medicine and Developmental Neurosciences, Translational Developmental Neuroscience Section, University Hospital C.G. Carus, Technische Universität Dresden, 01307 Dresden, GermanyDivision of Psychological and Social Medicine and Developmental Neurosciences, Translational Developmental Neuroscience Section, University Hospital C.G. Carus, Technische Universität Dresden, 01307 Dresden, GermanyDivision of Psychological and Social Medicine and Developmental Neurosciences, Translational Developmental Neuroscience Section, University Hospital C.G. Carus, Technische Universität Dresden, 01307 Dresden, GermanyInstitute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, GermanyDepartment of Psychotherapy and Psychosomatic Medicine, Faculty of Medicine, University Hospital C.G. Carus, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital C.G. Carus, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Psychology, Technische Universität Dresden, 01062 Dresden, GermanyDivision of Psychological and Social Medicine and Developmental Neurosciences, Translational Developmental Neuroscience Section, University Hospital C.G. Carus, Technische Universität Dresden, 01307 Dresden, GermanyAnorexia nervosa (AN) is a complex psychiatric disorder accompanied by a variety of endocrine effects. Altered levels of the sex steroid hormones progesterone and dehydroepiandrosterone (DHEA) have been shown to occur in patients with AN using short-term hormonal measurement methods based on blood, saliva, and urine samples. However, since sex steroid hormone levels fluctuate during the menstrual cycle, these measurement methods require a great deal of effort due to the need to collect multiple samples in order to correctly determine the basal level of sex hormones. In contrast, hair-based assessments provide a marker of accumulated longer-term hormone exposure using a single, non-invasive sample. The aim of this study was to investigate sex steroid hormone levels via hair-based assessments in acutely underweight AN in comparison with healthy, age-matched, female control participants. Additionally, we compared progesterone and DHEA hair levels longitudinally during inpatient treatment in AN. Collected hair samples were analyzed using liquid chromatography-mass spectrometry (LC-MS/MS) to determine a monthly hormone level of progesterone and DHEA. Our results indicate that DHEA hair hormone levels were similar across groups but progesterone was suppressed in underweight AN compared with healthy controls. In the longitudinal design, no significant change in hair hormone levels during partial weight restoration in patients with AN was observed. Our findings suggest that hair analysis can be used to detect suppressed progesterone levels in severe AN, and that progesterone does not increase during short-term weight restoration.https://www.mdpi.com/2218-1989/13/1/21anorexia nervosahair sample analysissex steroid hormonesprogesteroneDHEA |
| spellingShingle | Victoria-Luise Batury Friederike I. Tam Inger Hellerhoff Marie-Louis Wronski Katrin Borucki Kerstin Weidner Veit Roessner Wei Gao Stefan Ehrlich Hair-Based Assessment of Sex Steroid Hormones in Patients with Anorexia Nervosa Metabolites anorexia nervosa hair sample analysis sex steroid hormones progesterone DHEA |
| title | Hair-Based Assessment of Sex Steroid Hormones in Patients with Anorexia Nervosa |
| title_full | Hair-Based Assessment of Sex Steroid Hormones in Patients with Anorexia Nervosa |
| title_fullStr | Hair-Based Assessment of Sex Steroid Hormones in Patients with Anorexia Nervosa |
| title_full_unstemmed | Hair-Based Assessment of Sex Steroid Hormones in Patients with Anorexia Nervosa |
| title_short | Hair-Based Assessment of Sex Steroid Hormones in Patients with Anorexia Nervosa |
| title_sort | hair based assessment of sex steroid hormones in patients with anorexia nervosa |
| topic | anorexia nervosa hair sample analysis sex steroid hormones progesterone DHEA |
| url | https://www.mdpi.com/2218-1989/13/1/21 |
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