Pentosan Polysulfate Sodium-Associated Pigmentary Retinopathy: Risk Factors and Fundus Findings
Ella H Leung,1 Sahana Sharma,2 Ana Levie-Sprick,1 Gregory D Lee,1 Hyung Cho,1 Krishna Mukkamala1 1Georgia Retina, Atlanta, GA, USA; 2Vanderbilt University, Nashville, TN, USACorrespondence: Ella H LeungGeorgia Retina, 833 Campbell Hill St NW, Suite 300, Marietta, GA, 30060, USATel +1-770-218-1888Ema...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-12-01
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| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/pentosan-polysulfate-sodium-associated-pigmentary-retinopathy-risk-fac-peer-reviewed-fulltext-article-OPTH |
| _version_ | 1819096077274447872 |
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| author | Leung EH Sharma S Levie-Sprick A Lee GD Cho H Mukkamala SK |
| author_facet | Leung EH Sharma S Levie-Sprick A Lee GD Cho H Mukkamala SK |
| author_sort | Leung EH |
| collection | DOAJ |
| description | Ella H Leung,1 Sahana Sharma,2 Ana Levie-Sprick,1 Gregory D Lee,1 Hyung Cho,1 Krishna Mukkamala1 1Georgia Retina, Atlanta, GA, USA; 2Vanderbilt University, Nashville, TN, USACorrespondence: Ella H LeungGeorgia Retina, 833 Campbell Hill St NW, Suite 300, Marietta, GA, 30060, USATel +1-770-218-1888Email eleung@garetina.comPurpose: To evaluate the risk factors and fundus findings of patients with potential PPS-associated retinopathy.Patients and Methods: A retrospective chart review was performed of patients exposed to PPS who had a dilated fundus examination at a large retina-only practice from 2018– 21. Multimodal images were evaluated by masked reviewers.Results: A total of 148 patients were included, of whom 33 (22%) had PPS-associated retinopathy, and 115 (78%) did not. The mean age was 60.3 years old, and the mean follow-up was 11.8 months. The PPS-associated retinopathy group had higher mean cumulative doses of PPS (1600g± 849 vs 864g± 852, P < 0.0001, Mann–Whitney test) and longer duration of PPS use (13.6 years vs 7.48, P < 0.0001). There was no statistically significant difference based on a history of kidney or liver disease or the dosage per day for the weight, body mass index, body surface area, or lean body weight. Of the patients with PPS-associated retinopathy whose genetic results were available, 15 of 16 (93%) were heterozygous for variants of uncertain significance.Conclusion: A longer duration of PPS use and higher cumulative dosage of PPS were associated with an increased risk of developing PPS-associated pigmentary retinopathy. The role of genetic mutations in patients exposed to PPS is still to be determined.Keywords: pentosan polysulfate sodium, pigmentary retinopathy, pharmacotoxicity, inherited retinal dystrophies, genetics |
| first_indexed | 2024-12-21T23:53:27Z |
| format | Article |
| id | doaj.art-89bd42a6671e490da81e806e9cab4cd2 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-21T23:53:27Z |
| publishDate | 2021-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-89bd42a6671e490da81e806e9cab4cd22022-12-21T18:45:52ZengDove Medical PressClinical Ophthalmology1177-54832021-12-01Volume 154809481671786Pentosan Polysulfate Sodium-Associated Pigmentary Retinopathy: Risk Factors and Fundus FindingsLeung EHSharma SLevie-Sprick ALee GDCho HMukkamala SKElla H Leung,1 Sahana Sharma,2 Ana Levie-Sprick,1 Gregory D Lee,1 Hyung Cho,1 Krishna Mukkamala1 1Georgia Retina, Atlanta, GA, USA; 2Vanderbilt University, Nashville, TN, USACorrespondence: Ella H LeungGeorgia Retina, 833 Campbell Hill St NW, Suite 300, Marietta, GA, 30060, USATel +1-770-218-1888Email eleung@garetina.comPurpose: To evaluate the risk factors and fundus findings of patients with potential PPS-associated retinopathy.Patients and Methods: A retrospective chart review was performed of patients exposed to PPS who had a dilated fundus examination at a large retina-only practice from 2018– 21. Multimodal images were evaluated by masked reviewers.Results: A total of 148 patients were included, of whom 33 (22%) had PPS-associated retinopathy, and 115 (78%) did not. The mean age was 60.3 years old, and the mean follow-up was 11.8 months. The PPS-associated retinopathy group had higher mean cumulative doses of PPS (1600g± 849 vs 864g± 852, P < 0.0001, Mann–Whitney test) and longer duration of PPS use (13.6 years vs 7.48, P < 0.0001). There was no statistically significant difference based on a history of kidney or liver disease or the dosage per day for the weight, body mass index, body surface area, or lean body weight. Of the patients with PPS-associated retinopathy whose genetic results were available, 15 of 16 (93%) were heterozygous for variants of uncertain significance.Conclusion: A longer duration of PPS use and higher cumulative dosage of PPS were associated with an increased risk of developing PPS-associated pigmentary retinopathy. The role of genetic mutations in patients exposed to PPS is still to be determined.Keywords: pentosan polysulfate sodium, pigmentary retinopathy, pharmacotoxicity, inherited retinal dystrophies, geneticshttps://www.dovepress.com/pentosan-polysulfate-sodium-associated-pigmentary-retinopathy-risk-fac-peer-reviewed-fulltext-article-OPTHpentosan polysulfate sodiumpigmentary retinopathypharmacotoxicityinherited retinal dystrophiesgenetics |
| spellingShingle | Leung EH Sharma S Levie-Sprick A Lee GD Cho H Mukkamala SK Pentosan Polysulfate Sodium-Associated Pigmentary Retinopathy: Risk Factors and Fundus Findings Clinical Ophthalmology pentosan polysulfate sodium pigmentary retinopathy pharmacotoxicity inherited retinal dystrophies genetics |
| title | Pentosan Polysulfate Sodium-Associated Pigmentary Retinopathy: Risk Factors and Fundus Findings |
| title_full | Pentosan Polysulfate Sodium-Associated Pigmentary Retinopathy: Risk Factors and Fundus Findings |
| title_fullStr | Pentosan Polysulfate Sodium-Associated Pigmentary Retinopathy: Risk Factors and Fundus Findings |
| title_full_unstemmed | Pentosan Polysulfate Sodium-Associated Pigmentary Retinopathy: Risk Factors and Fundus Findings |
| title_short | Pentosan Polysulfate Sodium-Associated Pigmentary Retinopathy: Risk Factors and Fundus Findings |
| title_sort | pentosan polysulfate sodium associated pigmentary retinopathy risk factors and fundus findings |
| topic | pentosan polysulfate sodium pigmentary retinopathy pharmacotoxicity inherited retinal dystrophies genetics |
| url | https://www.dovepress.com/pentosan-polysulfate-sodium-associated-pigmentary-retinopathy-risk-fac-peer-reviewed-fulltext-article-OPTH |
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