Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase
Cytochrome c oxidase (COX), the rate-limiting enzyme of mitochondrial respiration, is regulated by various mechanisms. Its regulation by ATP (adenosine triphosphate) appears of particular importance, since it evolved early during evolution and is still found in cyanobacteria, but not in other bacter...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/3/514 |
| _version_ | 1797416877831487488 |
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| author | Rabia Ramzan Bernhard Kadenbach Sebastian Vogt |
| author_facet | Rabia Ramzan Bernhard Kadenbach Sebastian Vogt |
| author_sort | Rabia Ramzan |
| collection | DOAJ |
| description | Cytochrome c oxidase (COX), the rate-limiting enzyme of mitochondrial respiration, is regulated by various mechanisms. Its regulation by ATP (adenosine triphosphate) appears of particular importance, since it evolved early during evolution and is still found in cyanobacteria, but not in other bacteria. Therefore the “allosteric ATP inhibition of COX” is described here in more detail. Most regulatory properties of COX are related to “supernumerary” subunits, which are largely absent in bacterial COX. The “allosteric ATP inhibition of COX” was also recently described in intact isolated rat heart mitochondria. |
| first_indexed | 2024-03-09T06:10:38Z |
| format | Article |
| id | doaj.art-89c2362a3018409fa183b973c7a91ac7 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T06:10:38Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-89c2362a3018409fa183b973c7a91ac72023-12-03T11:59:12ZengMDPI AGCells2073-44092021-02-0110351410.3390/cells10030514Multiple Mechanisms Regulate Eukaryotic Cytochrome C OxidaseRabia Ramzan0Bernhard Kadenbach1Sebastian Vogt2Cardiovascular Research Laboratory, Biochemical-Pharmacological Center, Philipps-University Marburg, Karl-von-Frisch-Strasse 1, D-35043 Marburg, GermanyFachbereich Chemie, Philipps-University, D-35032 Marburg, GermanyDepartment of Heart Surgery, Campus Marburg, University Hospital of Giessen and Marburg, D-35043 Marburg, GermanyCytochrome c oxidase (COX), the rate-limiting enzyme of mitochondrial respiration, is regulated by various mechanisms. Its regulation by ATP (adenosine triphosphate) appears of particular importance, since it evolved early during evolution and is still found in cyanobacteria, but not in other bacteria. Therefore the “allosteric ATP inhibition of COX” is described here in more detail. Most regulatory properties of COX are related to “supernumerary” subunits, which are largely absent in bacterial COX. The “allosteric ATP inhibition of COX” was also recently described in intact isolated rat heart mitochondria.https://www.mdpi.com/2073-4409/10/3/514mitochondriaenergy metabolismrespirationregulationcytochrome c oxidaseadenine nucleotides |
| spellingShingle | Rabia Ramzan Bernhard Kadenbach Sebastian Vogt Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase Cells mitochondria energy metabolism respiration regulation cytochrome c oxidase adenine nucleotides |
| title | Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase |
| title_full | Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase |
| title_fullStr | Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase |
| title_full_unstemmed | Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase |
| title_short | Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase |
| title_sort | multiple mechanisms regulate eukaryotic cytochrome c oxidase |
| topic | mitochondria energy metabolism respiration regulation cytochrome c oxidase adenine nucleotides |
| url | https://www.mdpi.com/2073-4409/10/3/514 |
| work_keys_str_mv | AT rabiaramzan multiplemechanismsregulateeukaryoticcytochromecoxidase AT bernhardkadenbach multiplemechanismsregulateeukaryoticcytochromecoxidase AT sebastianvogt multiplemechanismsregulateeukaryoticcytochromecoxidase |