Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers
Affinity matured self-reactive antibodies are found in autoimmune diseases like systemic lupus erythematous. Here, we used fate-mapping reporter mice and single-cell transcriptomics coupled to antibody repertoire analysis to characterize the post-germinal center (GC) B cell compartment in a new mous...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2023-06-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/81012 |