Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives
Novel series of heterocyclic compounds 2-aryl-1-(4-(naphthalen-2-yl)thiazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid derivatives (4a–h) and 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl) pyrrolidin-2-one derivatives (5a–h) have been synthesized by condensation of Schiff base...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Mato Grosso do Sul
2015-09-01
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| Series: | Orbital: The Electronic Journal of Chemistry |
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| Online Access: | https://periodicos.ufms.br/index.php/orbital/article/view/17865 |
| _version_ | 1797946787288317952 |
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| author | Kandarp H. Patel Yogesh S. Patel |
| author_facet | Kandarp H. Patel Yogesh S. Patel |
| author_sort | Kandarp H. Patel |
| collection | DOAJ |
| description | Novel series of heterocyclic compounds 2-aryl-1-(4-(naphthalen-2-yl)thiazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid derivatives (4a–h) and 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl) pyrrolidin-2-one derivatives (5a–h) have been synthesized by condensation of Schiff bases arylidine-[4-(2-naphthalenyl)thiazolyl]-2-amines (3a–h) with succinic anhydride. Synthesized heterocyclic compounds were duly characterized by physico chemical parameters, 1H-NMR, 13C-NMR and FT–IR spectral features. Schiff bases 3a–h have been synthesized from 4-(naphthalen-2-yl)thiazol-2-amine 1 and various aromatic aldehydes 2a–h. All novel synthesized compounds 4a–h and 5a–h were evaluated for their antibacterial activity against various Gram positive bacterial strains e.g. Bacillus subtilis [BS] and Staphylococcus aureus [SA] and Gram negative bacterial strains e.g. Salmonella typhimurium [ST] and Escherichia coli [EC]. Growth inhibition was compared with the standard drug ciprofloxacin. Antifungal activity was also carried out against different fungal strains e.g. Penicillium expansum [PE], Botryodiplodia theobromae [BT], Nigrospora sp. [NS], Trichothesium sp. [TS]. The antifungal drug, Ketoconazole was used as a positive control. Compounds 4a–h found less active as compare to compound 5a–h.
DOI: http://dx.doi.org/10.17807/orbital.v7i3.723
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| first_indexed | 2024-04-10T21:17:35Z |
| format | Article |
| id | doaj.art-89c32696012442529d17214c61cf29e4 |
| institution | Directory Open Access Journal |
| issn | 1984-6428 |
| language | English |
| last_indexed | 2024-04-10T21:17:35Z |
| publishDate | 2015-09-01 |
| publisher | Universidade Federal de Mato Grosso do Sul |
| record_format | Article |
| series | Orbital: The Electronic Journal of Chemistry |
| spelling | doaj.art-89c32696012442529d17214c61cf29e42023-01-20T11:04:02ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282015-09-0173Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one DerivativesKandarp H. Patel0Yogesh S. Patel1Department of Research and Development, Adventus LaboratoriesDepartment of Chemistry, Government Science College, GandhinagarNovel series of heterocyclic compounds 2-aryl-1-(4-(naphthalen-2-yl)thiazol-2-yl)-5-oxopyrrolidine-3-carboxylic acid derivatives (4a–h) and 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl) pyrrolidin-2-one derivatives (5a–h) have been synthesized by condensation of Schiff bases arylidine-[4-(2-naphthalenyl)thiazolyl]-2-amines (3a–h) with succinic anhydride. Synthesized heterocyclic compounds were duly characterized by physico chemical parameters, 1H-NMR, 13C-NMR and FT–IR spectral features. Schiff bases 3a–h have been synthesized from 4-(naphthalen-2-yl)thiazol-2-amine 1 and various aromatic aldehydes 2a–h. All novel synthesized compounds 4a–h and 5a–h were evaluated for their antibacterial activity against various Gram positive bacterial strains e.g. Bacillus subtilis [BS] and Staphylococcus aureus [SA] and Gram negative bacterial strains e.g. Salmonella typhimurium [ST] and Escherichia coli [EC]. Growth inhibition was compared with the standard drug ciprofloxacin. Antifungal activity was also carried out against different fungal strains e.g. Penicillium expansum [PE], Botryodiplodia theobromae [BT], Nigrospora sp. [NS], Trichothesium sp. [TS]. The antifungal drug, Ketoconazole was used as a positive control. Compounds 4a–h found less active as compare to compound 5a–h. DOI: http://dx.doi.org/10.17807/orbital.v7i3.723 https://periodicos.ufms.br/index.php/orbital/article/view/17865heterocyclic compoundsthiazolebenzimidazolepyrrolidin-2-one |
| spellingShingle | Kandarp H. Patel Yogesh S. Patel Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives Orbital: The Electronic Journal of Chemistry heterocyclic compounds thiazole benzimidazole pyrrolidin-2-one |
| title | Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives |
| title_full | Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives |
| title_fullStr | Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives |
| title_full_unstemmed | Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives |
| title_short | Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives |
| title_sort | studies of 5 aryl 4 1h benzo d imidazol 2 yl 1 4 naphthalen 2 yl thiazol 2 yl pyrrolidin 2 one derivatives |
| topic | heterocyclic compounds thiazole benzimidazole pyrrolidin-2-one |
| url | https://periodicos.ufms.br/index.php/orbital/article/view/17865 |
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